IL37 interleukin 37 [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL37provided by HGNC
Official Full Name: interleukin 37provided by HGNC
Primary source: HGNC:HGNC:15563
See related: Ensembl:ENSG00000125571 MIM:605510; AllianceGenome:HGNC:15563
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FIL1; FIL1Z; IL-1H; IL-23; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
Summary: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression: Restricted expression toward skin (RPKM 8.8) See more
Orthologs: all
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Genomic context

Location:: 2q14.1

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	2	NC_000002.12 (112911165..112918882)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	2	NC_060926.1 (113337679..113345401)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	2	NC_000002.11 (113668742..113676459)

Chromosome 2 - NC_000002.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment.
Title: IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment.
Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro.
Title: Interleukin-37 relieves PM2.5-triggered lung injury by inhibiting autophagy through the AKT/mTOR signaling pathway in vivo and in vitro.
Potential Role of IL-37 in Atopic Dermatitis.
Title: Potential Role of IL-37 in Atopic Dermatitis.
[Expression of interleukin-37, vascular endothelial growth factor A, and transforming growth factor-beta1 and their correlation with T cells in children with primary immune thrombocytopenia].
Title: [Expression of interleukin-37, vascular endothelial growth factor A, and transforming growth factor-β1 and their correlation with T cells in children with primary immune thrombocytopenia].
Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process.
Title: Novel insights into IL-37: an anti-inflammatory cytokine with emerging roles in anti-cancer process.
Correlation analysis of IL-37 gene polymorphisms and susceptibility to chronic HBV infection among Han people in Central China.
Title: Correlation analysis of IL-37 gene polymorphisms and susceptibility to chronic HBV infection among Han people in Central China.
Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity.
Title: Modulation of intestinal IL-37 expression and its impact on the epithelial innate immune response and barrier integrity.
Interleukin-37: associations of plasma levels and genetic variants in gout.
Title: Interleukin-37: associations of plasma levels and genetic variants in gout.
Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus.
Title: Upregulation of IL-37 in epithelial cells: A potential new mechanism of T cell inhibition induced by tacrolimus.
Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte dissociation via upregulation of Caveolin-1 and inhibition of the STAT3 pathway.
Title: Interleukin-37 inhibits desmoglein-3 endocytosis and keratinocyte dissociation via upregulation of Caveolin-1 and inhibition of the STAT3 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (234)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Inflammatory bowel disease (infantile ulcerative colitis) 31, autosomal recessive MedGen: C5444224 OMIM: 619398 GeneReviews: Not available	not available

EBI GWAS Catalog

Description
Genome-wide association study of lung function phenotypes in a founder population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of peripheral neuropathy with D-drug-containing regimens in AIDS Clinical Trials Group protocol 384. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables interleukin-1 receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables interleukin-1 receptor binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in inflammatory response to antigenic stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of negative regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of inflammatory response	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: interleukin-37

Names: FIL1 zeta; IL-1 zeta; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL-1X protein; IL1F7 (canonical product IL-1F7b); interleukin 1 family member 7; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin-1-related protein; interleukin-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029219.1 RefSeqGene

Range

3195..10912

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_014439.4 → NP_055254.2 interleukin-37 isoform 1

See identical proteins and their annotated locations for NP_055254.2

Status: REVIEWED

Source sequence(s)

AC079753

Consensus CDS

CCDS2103.1

UniProtKB/Swiss-Prot

B5BU97, Q56AP9, Q8TD04, Q8TD05, Q9HBF2, Q9HBF3, Q9NZH6, Q9UHA6

UniProtKB/TrEMBL

Q7RU00

Related

ENSP00000263326.3, ENST00000263326.8

Conserved Domains (1) summary

cl00094
Location:59 → 204

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_173202.2 → NP_775294.1 interleukin-37 isoform 2

See identical proteins and their annotated locations for NP_775294.1

Status: REVIEWED

Source sequence(s)

AC079753

Consensus CDS

CCDS2104.1

UniProtKB/TrEMBL

Q7RU00

Related

ENSP00000263327.3, ENST00000352179.7

Conserved Domains (1) summary

cl00094
Location:38 → 183

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_173203.2 → NP_775295.1 interleukin-37 isoform 3

See identical proteins and their annotated locations for NP_775295.1

Status: REVIEWED

Source sequence(s)

AC079753

Consensus CDS

CCDS2105.1

UniProtKB/Swiss-Prot

Q9NZH6

Related

ENSP00000263328.3, ENST00000349806.7

Conserved Domains (1) summary

cl00094
Location:47 → 143

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_173204.2 → NP_775296.1 interleukin-37 isoform 4

See identical proteins and their annotated locations for NP_775296.1

Status: REVIEWED

Source sequence(s)

AC079753

Consensus CDS

CCDS2106.1

UniProtKB/TrEMBL

Q7RU00

Related

ENSP00000309208.3, ENST00000353225.7

Conserved Domains (1) summary

cl00094
Location:68 → 164

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).
NM_173205.2 → NP_775297.1 interleukin-37 isoform 5

See identical proteins and their annotated locations for NP_775297.1

Status: REVIEWED

Source sequence(s)

AC079753

Consensus CDS

CCDS2107.1

UniProtKB/Swiss-Prot

Q9NZH6

Related

ENSP00000309883.2, ENST00000311328.2

Conserved Domains (1) summary

cl00094
Location:33 → 178

IL1; Interleukin-1 homologes; Cytokines with various biological functions. Interleukin 1 alpha and beta are also known as hematopoietin and catabolin. This family also contains interleukin-1 receptor antagonists (inhibitors).