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TAF5L TATA-box binding protein associated factor 5 like [ Homo sapiens (human) ]

Gene ID: 27097, updated on 5-Mar-2024

Summary

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Official Symbol
TAF5Lprovided by HGNC
Official Full Name
TATA-box binding protein associated factor 5 likeprovided by HGNC
Primary source
HGNC:HGNC:17304
See related
Ensembl:ENSG00000135801 AllianceGenome:HGNC:17304
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAF65B
Summary
The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 3.7), fat (RPKM 3.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
1q42.13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (229593134..229626122, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (228972074..229005072, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (229728881..229761869, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1932 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2704 Neighboring gene RNA, 5S ribosomal pseudogene 78 Neighboring gene high mobility group nucleosomal binding domain 2 pseudogene 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:229730263-229730763 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:229759383-229759933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2705 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:229771551-229772052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:229772053-229772552 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2707 Neighboring gene URB2 ribosome biogenesis homolog Neighboring gene KIAA1191 pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients. Chistiakov DA, et al. Autoimmunity, 2005 Jun. PMID 16206511
  2. Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity. Kuninger D, et al. Am J Physiol Cell Physiol, 2006 Oct. PMID 16672693
  3. Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. Ravnskjaer K, et al. EMBO J, 2007 Jun 20. PMID 17476304, Free PMC Article
  4. PCAF modulates PTEN activity. Okumura K, et al. J Biol Chem, 2006 Sep 8. PMID 16829519
  5. Six lysine residues on c-Myc are direct substrates for acetylation by p300. Zhang K, et al. Biochem Biophys Res Commun, 2005 Oct 14. PMID 16126174

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients.
  2. latent cytoplasmic coactivator TORC2 mediates target gene activation in response to cAMP signaling by associating with CBP/p300 and increasing its recruitment to a subset of CREB target genes
    Title: Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression.
  3. The TAF5L gene on chromosome 1q42 is associated tie type 1 diabetes in Russian patients.
    Title: The TAF5L gene on chromosome 1q42 is associated with type 1 diabetes in Russian affected patients.
  4. p300 can acetylate DNA-bound Myc:Max complexes and that acetylated Myc:Max heterodimers efficiently interact with Miz-1
    Title: Six lysine residues on c-Myc are direct substrates for acetylation by p300.
  5. p300 or PCAF maintains myoblast viability as effectively as added growth factors through mechanisms requiring the acetyltransferase activity of PCAF but not of p300.
    Title: Muscle cell survival mediated by the transcriptional coactivators p300 and PCAF displays different requirements for acetyltransferase activity.
  6. PCAF is a histone acetyltransferase which regulates gene transcription. PCAF interacts physically and functionally with PTEN. PTEN acetylation by PCAF block the ability of PTEN to downregulate PI3-K signalling and to induce G1 cell cycle arrest.
    Title: PCAF modulates PTEN activity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of RNA splicing NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of somatic stem cell population maintenance ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SAGA complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SAGA complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
  
part_of histone acetyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear protein-containing complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
NOT part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFTC complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFTC complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L
Names
PAF65-beta
PCAF-associated factor 65 beta
TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025247.2 → NP_001020418.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform b

    See identical proteins and their annotated locations for NP_001020418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and the 5' coding region, compared to variant 1. The resulting isoform (b) contains a distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AF069736, AI251746, AL121990, BC041094
    Consensus CDS
    CCDS31051.1
    UniProtKB/Swiss-Prot
    O75529
    Related
    ENSP00000355635.3, ENST00000366675.3
    Conserved Domains (2) summary
    cd08044
    Location:67 → 201
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    sd00039
    Location:272 → 304
    7WD40; WD40 repeat [structural motif]

  2. NM_014409.4 → NP_055224.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform a

    See identical proteins and their annotated locations for NP_055224.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript, but encodes the longer isoform (a).
    Source sequence(s)
    AF069736, AI251746, AJ009770, AL121990, BC041094
    Consensus CDS
    CCDS1581.1
    UniProtKB/Swiss-Prot
    O75529, Q5TDI5, Q5TDI6, Q8IW31
    Related
    ENSP00000258281.2, ENST00000258281.7
    Conserved Domains (3) summary
    cd08044
    Location:67 → 201
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    cd00200
    Location:276 → 581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:273 → 340
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    229593134..229626122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273099.5 → XP_005273156.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X1

    See identical proteins and their annotated locations for XP_005273156.1

    UniProtKB/Swiss-Prot
    O75529, Q5TDI5, Q5TDI6, Q8IW31
    Conserved Domains (3) summary
    cd08044
    Location:67 → 201
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    cd00200
    Location:276 → 581
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:273 → 340
    7WD40; WD40 repeat [structural motif]

  2. XM_047417997.1 → XP_047273953.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X3

  3. XM_011544162.2 → XP_011542464.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X2

    Conserved Domains (4) summary
    cd08044
    Location:13 → 130
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    COG2319
    Location:183 → 485
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:205 → 510
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:202 → 269
    7WD40; WD40 repeat [structural motif]

  4. XM_047417996.1 → XP_047273952.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X3

  5. XM_011544164.3 → XP_011542466.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X3

    See identical proteins and their annotated locations for XP_011542466.1

    Conserved Domains (3) summary
    cd08044
    Location:2 → 109
    TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
    cd00200
    Location:184 → 489
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:181 → 248
    7WD40; WD40 repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    228972074..229005072 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054336005.1 → XP_054191980.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X1

    UniProtKB/Swiss-Prot
    O75529, Q5TDI5, Q5TDI6, Q8IW31

  2. XM_054336008.1 → XP_054191983.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X3

  3. XM_054336006.1 → XP_054191981.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X2

  4. XM_054336007.1 → XP_054191982.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X3

  5. XM_054336009.1 → XP_054191984.1  TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75529.1 GenPept UniProtKB/Swiss-Prot:O75529

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