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Omd osteomodulin [ Mus musculus (house mouse) ]

Gene ID: 27047, updated on 28-Oct-2024

Summary

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Official Symbol
Omdprovided by MGI
Official Full Name
osteomodulinprovided by MGI
Primary source
MGI:MGI:1350918
See related
Ensembl:ENSMUSG00000048368 AllianceGenome:MGI:1350918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OSAD; SLRR2C
Summary
Predicted to be involved in cell adhesion. Located in extracellular matrix. Is expressed in extracellular matrix and jaw. Orthologous to human OMD (osteomodulin). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Omd in Genome Data Viewer
Location:
13 A5; 13 25.33 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (49735938..49746088)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (49582462..49592612)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene centromere protein P Neighboring gene extracellular matrix protein 2, female organ and adipocyte specific Neighboring gene asporin Neighboring gene STARR-seq mESC enhancer starr_34480 Neighboring gene osteoglycin Neighboring gene STARR-positive B cell enhancer ABC_E1463 Neighboring gene nucleolar protein 8 Neighboring gene predicted gene, 53786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size. Zhao W, et al. J Bone Miner Res, 2024 Aug 5. PMID 38722812, Free PMC Article
  2. Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells. Hamaya E, et al. Int J Mol Med, 2019 Dec. PMID 31638177
  3. Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization. Rehn AP, et al. Calcif Tissue Int, 2008 Jun. PMID 18496725
  4. Osteoclastic activity induces osteomodulin expression in osteoblasts. Ninomiya K, et al. Biochem Biophys Res Commun, 2007 Oct 19. PMID 17714690
  5. Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2. Rehn AP, et al. Biochem Biophys Res Commun, 2006 Oct 27. PMID 16970923

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size.
    Title: Osteomodulin deficiency in mice causes a specific reduction of transversal cortical bone size.
  2. Osteomodulin downregulation is associated with osteoarthritis development.
    Title: Osteomodulin downregulation is associated with osteoarthritis development.
  3. These results demonstrate that Omd expression is regulated during osteoblast differentiation, and that the protein product osteoadherin serves roles in the apoptosis and growth of osteoblast cells
    Title: Osteoadherin serves roles in the regulation of apoptosis and growth in MC3T3‑E1 osteoblast cells.
  4. OSAD overexpression enhanced the differentiation and maturation of osteoblasts in vitro.
    Title: Osteoadherin is upregulated by mature osteoblasts and enhances their in vitro differentiation and mineralization.
  5. found transforming growth factor beta1 to down regulate OSAD, while bone morphogenetic protein 2 up regulates OSAD
    Title: Differential regulation of osteoadherin (OSAD) by TGF-beta1 and BMP-2.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Targeted (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
osteomodulin
Names
KSPG osteomodulin
keratan sulfate proteoglycan osteomodulin
osteoadherin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360708.1 → NP_001347637.1  osteomodulin precursor

    Status: VALIDATED

    Source sequence(s)
    AC160978
    Consensus CDS
    CCDS26504.1
    UniProtKB/Swiss-Prot
    O35103
    UniProtKB/TrEMBL
    Q501L5
    Related
    ENSMUSP00000065706.8, ENSMUST00000065494.8
    Conserved Domains (2) summary
    PRK15370
    Location:68 → 302
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:94 → 116
    LRR_RI; leucine-rich repeat [structural motif]

  2. NM_012050.3 → NP_036180.1  osteomodulin precursor

    See identical proteins and their annotated locations for NP_036180.1

    Status: VALIDATED

    Source sequence(s)
    AC160978
    Consensus CDS
    CCDS26504.1
    UniProtKB/Swiss-Prot
    O35103
    UniProtKB/TrEMBL
    Q501L5
    Related
    ENSMUSP00000152066.2, ENSMUST00000221170.2
    Conserved Domains (2) summary
    PRK15370
    Location:68 → 302
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    sd00033
    Location:94 → 116
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    49735938..49746088
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35103.1 GenPept UniProtKB/Swiss-Prot:O35103

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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