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UL8 helicase-primase subunit [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703432, updated on 18-Aug-2023

Summary

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Gene symbol
UL8
Gene description
helicase-primase subunit
Locus tag
HHV1gp00p67
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (18211..20477, complement)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene nuclear protein UL4 Neighboring gene helicase-primase helicase subunit Neighboring gene capsid portal protein Neighboring gene tegument protein UL7 Neighboring gene DNA replication origin-binding helicase Neighboring gene envelope glycoprotein M Neighboring gene myristylated tegument protein Neighboring gene deoxyribonuclease Neighboring gene tegument serine/threonine protein kinase Neighboring gene tegument protein UL14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The UL8 subunit of the helicase-primase complex of herpes simplex virus promotes DNA annealing and has a high affinity for replication forks. Bermek O, et al. J Biol Chem, 2017 Sep 22. PMID 28743747, Free PMC Article
  2. Herpesviral helicase-primase subunit UL8 is inactivated B-family polymerase. Kazlauskas D, et al. Bioinformatics, 2014 Aug 1. PMID 24747220
  3. Identification of conserved amino acids in the herpes simplex virus type 1 UL8 protein required for DNA synthesis and UL52 primase interaction in the virus replisome. Muylaert I, et al. J Biol Chem, 2012 Sep 28. PMID 22851167, Free PMC Article
  4. UL52 primase interactions in the herpes simplex virus 1 helicase-primase are affected by antiviral compounds and mutations causing drug resistance. Muylaert I, et al. J Biol Chem, 2014 Nov 21. PMID 25278021, Free PMC Article
  5. Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation. Chen Y, et al. J Virol, 2011 Jan. PMID 21068246, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UL8 may be involved in the generation of the X- and Y-branched structures that are the hallmarks of HSV replication
    Title: The UL8 subunit of the helicase-primase complex of herpes simplex virus promotes DNA annealing and has a high affinity for replication forks.
  2. Data indicate that the N-terminal domain of UL52 primase binds UL5 helicase and the middle domain interacts with UL8.
    Title: UL52 primase interactions in the herpes simplex virus 1 helicase-primase are affected by antiviral compounds and mutations causing drug resistance.
  3. UL8 protein family is related to B-family polymerases
    Title: Herpesviral helicase-primase subunit UL8 is inactivated B-family polymerase.
  4. HSV-1 single stranded DNA binding protein (ICP8), and the helicase/primase complex (UL8/UL5/UL52) form a nuclear complex in transfected cells that is necessary and sufficient to disable ATR signaling.
    Title: Herpes simplex virus type 1 single strand DNA binding protein and helicase/primase complex disable cellular ATR signaling.
  5. Identification of conserved amino acids in the herpes simplex virus type 1 UL8 protein required for DNA synthesis and UL52 primase interaction in the virus replisome
    Title: Identification of conserved amino acids in the herpes simplex virus type 1 UL8 protein required for DNA synthesis and UL52 primase interaction in the virus replisome.
  6. Taken together, these data suggest that the primase activity of the helicase-primase requires formation of a dimer or higher-order structure while ATPase activity does not.
    Title: Herpes simplex virus type 1 helicase-primase: DNA binding and consequent protein oligomerization and primase activation.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: c18216-18211 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
helicase-primase subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    18211..20477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137082.1 helicase-primase subunit [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137082.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B9VQD5, P10192, Q09IC5
    UniProtKB/TrEMBL
    A0A2Z4HCK8, A0A5J6DVE7, G8H8D0, G8HBC1
    Conserved Domains (1) summary
    PHA03144
    Location:1 → 750
    PHA03144; helicase-primase primase subunit; Provisional
Nucleotide Protein
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