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RS1 transcriptional regulator ICP4 [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703391, updated on 9-Jun-2024

Summary

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Gene symbol
RS1
Gene description
transcriptional regulator ICP4
Locus tag
HHV1gp00p01
Gene type
protein coding
RNA name
transcriptional regulator ICP4
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (146737..151023)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene envelope glycoprotein E Neighboring gene membrane protein US8A Neighboring gene membrane protein US9 Neighboring gene virion protein US10 Neighboring gene tegument protein US11 Neighboring gene TAP transporter inhibitor ICP47

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The herpes viral transcription factor ICP4 forms a novel DNA recognition complex. Tunnicliffe RB, et al. Nucleic Acids Res, 2017 Jul 27. PMID 28505309, Free PMC Article
  2. Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus. Lerma L, et al. Virus Res, 2020 Apr 2. PMID 32045631
  3. The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22. Kalamvoki M, et al. J Virol, 2011 Sep. PMID 21734043, Free PMC Article
  4. Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells. Lester JT, et al. J Virol, 2011 Jun. PMID 21450820, Free PMC Article
  5. Biochemical analysis of infected cell polypeptide (ICP)0, ICP4, UL7 and UL23 incorporated into extracellular herpes simplex virus type 1 virions. Loret S, et al. J Gen Virol, 2012 Mar. PMID 22158881

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus.
    Title: Partial complementation between the immediate early proteins ICP4 of herpes simplex virus type 1 and IE180 of pseudorabies virus.
  2. Present the crystal structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its own promoter, revealing a novel homo-dimeric fold. We also studied the complex in solution by small angle X-Ray scattering, nuclear magnetic resonance and surface-plasmon resonance which indicated that, in addition to the globular domain, a flanking intrinsically disordered region also recognizes DNA.
    Title: The herpes viral transcription factor ICP4 forms a novel DNA recognition complex.
  3. The authors show biochemically that UL7 and UL23 are indeed mature virion tegument components that, unlike ICP0 and ICP4, are salt-extractable.
    Title: Biochemical analysis of infected cell polypeptide (ICP)0, ICP4, UL7 and UL23 incorporated into extracellular herpes simplex virus type 1 virions.
  4. The authors report that CLOCK is a component of the transcriptional complex that includes TFIID, ICP4, ICP27, and ICP22.
    Title: The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.
  5. the data suggest that ICP4 interacts with components of TFIID and Mediator in the context of viral infection, and this may explain the broad transactivation properties of ICP4.
    Title: Herpes simplex virus 1 ICP4 forms complexes with TFIID and mediator in virus-infected cells.
  6. The results suggest that the retention of ICP4 and ICP0 in the nucleus is a dynamic process that involves the function of other viral proteins.
    Title: Translocation and colocalization of ICP4 and ICP0 in cells infected with herpes simplex virus 1 mutants lacking glycoprotein E, glycoprotein I, or the virion host shutoff product of the UL41 gene.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: 146737-146742 regulatory_class = TATA_box
  • Loc: 151005-151010 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
transcriptional regulator ICP4
YP_009137149.1
  • immediate early protein; transcriptional regulator

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    146737..151023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137149.1 transcriptional regulator ICP4 [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137149.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P08392
    UniProtKB/TrEMBL
    A0A7S4WVU1, B9VQC5, G8HBH4
    Conserved Domains (1) summary
    PHA03307
    Location:51 → 1245
    PHA03307; transcriptional regulator ICP4; Provisional
Nucleotide Protein
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