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UL14 tegument protein UL14 [ Human alphaherpesvirus 1 (Herpes simplex virus type 1) ]

Gene ID: 2703384, updated on 31-Jan-2024

Summary

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Gene symbol
UL14
Gene description
tegument protein UL14
Locus tag
HHV1gp00p65
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human alphaherpesvirus 1 (strain: 17, acronym: HHV-1, acronym: HSV-1)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus
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Genomic context

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Sequence:
NC_001806.2 (24801..28916, complement)

NC_001806.2Genomic Context describing neighboring genes Neighboring gene helicase-primase subunit Neighboring gene DNA replication origin-binding helicase Neighboring gene envelope glycoprotein M Neighboring gene myristylated tegument protein Neighboring gene deoxyribonuclease Neighboring gene tegument serine/threonine protein kinase Neighboring gene DNA packaging terminase subunit 1 Neighboring gene tegument protein UL16 Neighboring gene DNA packaging tegument protein UL17 Neighboring gene capsid triplex subunit 2 Neighboring gene major capsid protein Neighboring gene envelope protein UL20

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001806.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular determinants responsible for the subcellular localization of HSV-1 UL4 protein. Pan WW, et al. Virol Sin, 2011 Oct. PMID 21979574, Free PMC Article
  2. The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids. Yamauchi Y, et al. J Virol, 2008 Feb. PMID 18032514, Free PMC Article
  3. The Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis. Oda S, et al. J Virol, 2016 Oct 1. PMID 27440890, Free PMC Article
  4. Screening and identification of host factors interacting with UL14 of herpes simplex virus 1. Wu F, et al. Med Microbiol Immunol, 2011 Aug. PMID 21512757
  5. Evolution of sexually transmitted and sexually transmissible human herpesviruses. Davison AJ. Ann N Y Acad Sci, 2011 Aug. PMID 22417106

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. UL51 amino acid residues Leu-111, Ile-119, and Tyr-123 were required for interaction with UL14 in herpes simplex virus 1-infected cells and the UL51-UL14 complex regulated final viral envelopment for efficient viral replication.
    Title: The Interaction between Herpes Simplex Virus 1 Tegument Proteins UL51 and UL14 and Its Role in Virion Morphogenesis.
  2. By constructing a series of deletion mutants fused with enhanced yellow fluorescent protein (EYFP), the nuclear export signals of UL4 were for the first time mapped to amino acid residues 178 to 186.
    Title: Molecular determinants responsible for the subcellular localization of HSV-1 UL4 protein.
  3. UL14 interacts with cellular factor TSC22D3 during replication.
    Title: Screening and identification of host factors interacting with UL14 of herpes simplex virus 1.
  4. UL14 (i) enhanced VP16 nuclear localization at the immediately early phase, thus indirectly regulating the expression of immediate-early genes, and (ii) was associated with efficient nuclear targeting of capsids.
    Title: The UL14 tegument protein of herpes simplex virus type 1 is required for efficient nuclear transport of the alpha transinducing factor VP16 and viral capsids.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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regulatory

  • Loc: c24806-24801 regulatory_class = polyA_signal_sequence

General protein information

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Preferred Names
tegument protein UL14

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001806.2 Reference assembly

    Range
    24801..28916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009137088.1 tegument protein UL14 [Human alphaherpesvirus 1]

    See identical proteins and their annotated locations for YP_009137088.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    B9VQE1, O09797, P04291, Q09IB9
    UniProtKB/TrEMBL
    A0A181ZGF0, A0A2Z2D8E1, A0A2Z2D8P5, D3YPH1, F8REE3, G8HBC7
    Conserved Domains (1) summary
    PHA03185
    Location:1 → 219
    PHA03185; UL14 tegument protein; Provisional
Nucleotide Protein
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