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Ermap erythroblast membrane-associated protein [ Mus musculus (house mouse) ]

Gene ID: 27028, updated on 2-Nov-2024

Summary

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Official Symbol
Ermapprovided by MGI
Official Full Name
erythroblast membrane-associated proteinprovided by MGI
Primary source
MGI:MGI:1349816
See related
Ensembl:ENSMUSG00000028644 AllianceGenome:MGI:1349816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Located in cytoplasmic vesicle. Is expressed in bone marrow; embryo; liver; and spleen. Orthologous to human ERMAP (erythroblast membrane associated protein (Scianna blood group)). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in liver E14 (RPKM 85.9), liver E14.5 (RPKM 83.6) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Ermap in Genome Data Viewer
Location:
4 D2.1; 4 55.34 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (119032654..119047210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (119175457..119190013, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 2 (facilitated glucose transporter), member 1 Neighboring gene predicted gene 12867 Neighboring gene STARR-positive B cell enhancer ABC_E422 Neighboring gene zinc finger protein 691 Neighboring gene small vasohibin binding protein Neighboring gene transmembrane protein 269

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses. Su M, et al. Cell Mol Immunol, 2021 Aug. PMID 32620788, Free PMC Article
  2. Cloning and characterization of human erythroid membrane-associated protein, human ERMAP. Xu H, et al. Genomics, 2001 Aug. PMID 11549310
  3. Ermap, a gene coding for a novel erythroid specific adhesion/receptor membrane protein. Ye TZ, et al. Gene, 2000 Jan 25. PMID 10721728
  4. Purification and Transcriptomic Analysis of Mouse Fetal Leydig Cells Reveals Candidate Genes for Specification of Gonadal Steroidogenic Cells. McClelland KS, et al. Biol Reprod, 2015 Jun. PMID 25855264
  5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses.
    Title: ERMAP is a B7 family-related molecule that negatively regulates T cell and macrophage responses.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
erythroid membrane-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369066.1 → NP_001355995.1  erythroid membrane-associated protein isoform b precursor

    Status: VALIDATED

    Source sequence(s)
    AL606975, BC063257
    UniProtKB/TrEMBL
    A2A7P7
    Conserved Domains (3) summary
    pfam13851
    Location:267 → 316
    GAS; Growth-arrest specific micro-tubule binding
    cl02614
    Location:319 → 501
    SPRY; SPRY domain
    cl11960
    Location:41 → 141
    Ig; Immunoglobulin domain

  2. NM_013848.3 → NP_038876.3  erythroid membrane-associated protein isoform a precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL606975
    Consensus CDS
    CCDS18571.2
    UniProtKB/Swiss-Prot
    Q3UV82, Q6P4T5, Q8CEH1, Q9JLN5
    UniProtKB/TrEMBL
    A2A7P7
    Related
    ENSMUSP00000159033.2, ENSMUST00000239029.2
    Conserved Domains (3) summary
    pfam13851
    Location:269 → 318
    GAS; Growth-arrest specific micro-tubule binding
    cl02614
    Location:321 → 503
    SPRY; SPRY domain
    cl11960
    Location:41 → 141
    Ig; Immunoglobulin domain

RNA

  1. NR_160957.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK036702, AL606975
    Related
    ENSMUST00000030396.15

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    119032654..119047210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503138.5 → XP_006503201.1  erythroid membrane-associated protein isoform X1

    UniProtKB/TrEMBL
    A2A7P7
    Conserved Domains (2) summary
    cl02614
    Location:381 → 563
    SPRY; SPRY domain
    cl11960
    Location:87 → 187
    Ig; Immunoglobulin domain

  2. XM_006503140.4 → XP_006503203.1  erythroid membrane-associated protein isoform X3

    UniProtKB/TrEMBL
    A2A7P7
    Conserved Domains (2) summary
    cl02614
    Location:361 → 543
    SPRY; SPRY domain
    cl11960
    Location:67 → 167
    Ig; Immunoglobulin domain

  3. XM_006503141.4 → XP_006503204.1  erythroid membrane-associated protein isoform X4

    See identical proteins and their annotated locations for XP_006503204.1

    UniProtKB/TrEMBL
    A2A7P7
    Conserved Domains (2) summary
    cl02614
    Location:335 → 517
    SPRY; SPRY domain
    cl11960
    Location:41 → 141
    Ig; Immunoglobulin domain

  4. XM_006503139.4 → XP_006503202.1  erythroid membrane-associated protein isoform X2

    UniProtKB/TrEMBL
    A2A7P7
    Conserved Domains (3) summary
    cd15813
    Location:367 → 549
    SPRY_PRY_TRIM20; PRY/SPRY domain in tripartite motif-binding protein 20 (TRIM20), also known as pyrin
    pfam13851
    Location:315 → 364
    GAS; Growth-arrest specific micro-tubule binding
    cl11960
    Location:87 → 187
    Ig; Immunoglobulin domain

  5. XM_030253591.1 → XP_030109451.1  erythroid membrane-associated protein isoform X4

    UniProtKB/TrEMBL
    A2A7P7
    Conserved Domains (2) summary
    cl02614
    Location:335 → 517
    SPRY; SPRY domain
    cl11960
    Location:41 → 141
    Ig; Immunoglobulin domain

  6. XM_006503143.4 → XP_006503206.1  erythroid membrane-associated protein isoform X5

    UniProtKB/TrEMBL
    E9QKE5
    Conserved Domains (1) summary
    cl11960
    Location:87 → 187
    Ig; Immunoglobulin domain

  7. XM_006503144.5 → XP_006503207.1  erythroid membrane-associated protein isoform X7

    UniProtKB/TrEMBL
    E9QKE5
    Conserved Domains (1) summary
    cl11960
    Location:87 → 187
    Ig; Immunoglobulin domain

  8. XM_017320248.3 → XP_017175737.1  erythroid membrane-associated protein isoform X8

    UniProtKB/TrEMBL
    E9QKE5
    Conserved Domains (1) summary
    cl11960
    Location:87 → 187
    Ig; Immunoglobulin domain

  9. XM_011240548.3 → XP_011238850.1  erythroid membrane-associated protein isoform X6

    Conserved Domains (1) summary
    cl11960
    Location:87 → 187
    Ig; Immunoglobulin domain

RNA

  1. XR_003954955.2 RNA Sequence

  2. XR_003954956.2 RNA Sequence

  3. XR_376323.4 RNA Sequence

  4. XR_867881.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JLN5.2 GenPept UniProtKB/Swiss-Prot:Q9JLN5

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