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Klhl18 kelch-like 18 [ Mus musculus (house mouse) ]

Gene ID: 270201, updated on 2-Nov-2024

Summary

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Official Symbol
Klhl18provided by MGI
Official Full Name
kelch-like 18provided by MGI
Primary source
MGI:MGI:2143315
See related
Ensembl:ENSMUSG00000054792 AllianceGenome:MGI:2143315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930041K15
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in nervous system and retina nuclear layer. Orthologous to human KLHL18 (kelch like family member 18). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.6), whole brain E14.5 (RPKM 7.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Klhl18 in Genome Data Viewer
Location:
9 F2; 9 59.92 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (110254994..110305768, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (110425926..110476737, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 23 Neighboring gene STARR-positive B cell enhancer ABC_E6807 Neighboring gene neutrophilic granule protein Neighboring gene STARR-positive B cell enhancer ABC_E8318 Neighboring gene kinesin family member 9 Neighboring gene STARR-seq mESC enhancer starr_25264 Neighboring gene SET domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss. Ingham NJ, et al. PLoS One, 2021. PMID 34597341, Free PMC Article
  2. Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. Lewis MA, et al. BMC Biol, 2022 Mar 17. PMID 35296311, Free PMC Article
  3. Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation. Chaya T, et al. EMBO J, 2019 Dec 2. PMID 31696965, Free PMC Article
  4. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  5. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss.
    Title: Inner hair cell dysfunction in Klhl18 mutant mice leads to low frequency progressive hearing loss.
  2. suggest that Cul3-Klhl18 modulates rod Talpha translocation during light/dark adaptation through Unc119 ubiquitination
    Title: Cul3-Klhl18 ubiquitin ligase modulates rod transducin translocation during light-dark adaptation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Clone Names

  • MGC36415

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of mitotic cell cycle phase transition ISO
Inferred from Sequence Orthology
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
kelch-like protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360306.1 → NP_001347235.1  kelch-like protein 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132103, AC160104, BC065167
    Consensus CDS
    CCDS90672.1
    UniProtKB/TrEMBL
    A0A0G2JGN5
    Related
    ENSMUSP00000143634.2, ENSMUST00000198164.5
    Conserved Domains (4) summary
    PHA03098
    Location:34 → 557
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:331 → 374
    Kelch; KELCH repeat [structural motif]
    cd18247
    Location:19 → 134
    BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
    cd18457
    Location:135 → 241
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

  2. NM_177771.5 → NP_808439.2  kelch-like protein 18 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132103, BC065167, BY195998, BY248410, CB247282, CF739377, CK619719
    Consensus CDS
    CCDS23567.1
    UniProtKB/Swiss-Prot
    E9Q4F2
    Related
    ENSMUSP00000069674.7, ENSMUST00000068025.13
    Conserved Domains (4) summary
    PHA03098
    Location:34 → 552
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:326 → 369
    Kelch; KELCH repeat [structural motif]
    cd18247
    Location:19 → 134
    BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
    cd18457
    Location:135 → 241
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    110254994..110305768 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244406.2 → XP_030100266.1  kelch-like protein 18 isoform X2

    Conserved Domains (3) summary
    PHA03098
    Location:3 → 440
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:214 → 257
    Kelch; KELCH repeat [structural motif]
    cd18457
    Location:23 → 129
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

  2. XM_030244405.2 → XP_030100265.1  kelch-like protein 18 isoform X1

    Conserved Domains (3) summary
    PHA03098
    Location:3 → 445
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:219 → 262
    Kelch; KELCH repeat [structural motif]
    cd18457
    Location:23 → 129
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)

  3. XM_017313405.3 → XP_017168894.1  kelch-like protein 18 isoform X3

    Conserved Domains (5) summary
    smart00612
    Location:318 → 370
    Kelch; Kelch domain
    sd00038
    Location:311 → 356
    Kelch; KELCH repeat [structural motif]
    cd18247
    Location:19 → 134
    BTB_POZ_KLHL18; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18)
    cd18457
    Location:135 → 270
    BACK_KLHL18; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18)
    pfam01344
    Location:359 → 404
    Kelch_1; Kelch motif
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q4F2.1 GenPept UniProtKB/Swiss-Prot:E9Q4F2

Gene LinkOut

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