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Rab6b RAB6B, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 270192, updated on 2-Nov-2024

Summary

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Official Symbol
Rab6bprovided by MGI
Official Full Name
RAB6B, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:107283
See related
Ensembl:ENSMUSG00000032549 AllianceGenome:MGI:107283
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630015C03; D9Bwg0185e; C330006L04Rik
Summary
Predicted to enable GTPase activity and myosin V binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; protein localization to Golgi membrane; and retrograde transport, endosome to Golgi. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus and presynapse. Is expressed in several structures, including gonad; nasal cavity epithelium; nervous system; neural retina; and spleen. Orthologous to human RAB6B (RAB6B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cortex adult (RPKM 50.6), frontal lobe adult (RPKM 45.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Rab6b in Genome Data Viewer
Location:
9 F1; 9 54.88 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (102988866..103062475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (103111667..103185276)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25080 Neighboring gene predicted gene, 31434 Neighboring gene solute carrier organic anion transporter family, member 2a1 Neighboring gene predicted gene, 22595 Neighboring gene STARR-seq mESC enhancer starr_25082 Neighboring gene STARR-positive B cell enhancer ABC_E8309 Neighboring gene predicted gene, 46128 Neighboring gene predicted gene, 51658 Neighboring gene STARR-positive B cell enhancer ABC_E6799 Neighboring gene signal recognition particle receptor, B subunit Neighboring gene transferrin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection. Domínguez Cadena LC, et al. Immunol Cell Biol, 2021 Nov. PMID 34555867
  2. Rab6-Mediated Polarized Transport of Synaptic Vesicle Precursors Is Essential for the Establishment of Neuronal Polarity and Brain Formation. Zhang Y, et al. J Neurosci, 2024 Jul 3. PMID 38830762,
  3. ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals. Nyitrai H, et al. Cell Rep, 2020 Jun 9. PMID 32521280, Free PMC Article
  4. Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport. Monier S, et al. Traffic, 2002 Apr. PMID 11929610
  5. RAB6 and dynein drive post-Golgi apical transport to prevent neuronal progenitor delamination. Brault JB, et al. EMBO Rep, 2022 Oct 6. PMID 35979738, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection.
    Title: Rab6b localizes to the Golgi complex in murine macrophages and promotes tumor necrosis factor release in response to mycobacterial infection.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin V binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Golgi organization ISO
Inferred from Sequence Orthology
more info
  
involved_in Golgi organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in intra-Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Rab-6B
NP_776142.1
XP_006511799.1
XP_006511800.1
XP_017168890.1
XP_030100263.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173781.4 → NP_776142.1  ras-related protein Rab-6B

    See identical proteins and their annotated locations for NP_776142.1

    Status: PROVISIONAL

    Source sequence(s)
    AC156633
    Consensus CDS
    CCDS23449.1
    UniProtKB/Swiss-Prot
    P61294
    UniProtKB/TrEMBL
    Q0PD53
    Related
    ENSMUSP00000035155.7, ENSMUST00000035155.8
    Conserved Domains (1) summary
    cd01861
    Location:14 → 174
    Rab6; Rab GTPase family 6 (Rab6)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    102988866..103062475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244403.1 → XP_030100263.1  ras-related protein Rab-6B isoform X3

  2. XM_006511737.3 → XP_006511800.1  ras-related protein Rab-6B isoform X2

    Conserved Domains (1) summary
    cd01861
    Location:21 → 170
    Rab6; Rab GTPase family 6 (Rab6)

  3. XM_017313401.1 → XP_017168890.1  ras-related protein Rab-6B isoform X4

    Conserved Domains (1) summary
    cl38936
    Location:50 → 69
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_006511736.5 → XP_006511799.1  ras-related protein Rab-6B isoform X1

    Conserved Domains (1) summary
    cd01861
    Location:50 → 200
    Rab6; Rab GTPase family 6 (Rab6)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61294.1 GenPept UniProtKB/Swiss-Prot:P61294

Gene LinkOut

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