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Galntl6 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6 [ Mus musculus (house mouse) ]

Gene ID: 270049, updated on 2-Nov-2024

Summary

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Official Symbol
Galntl6provided by MGI
Official Full Name
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6provided by MGI
Primary source
MGI:MGI:1913581
See related
Ensembl:ENSMUSG00000096914 AllianceGenome:MGI:1913581
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A830023L05; 1700021K10Rik; 4930431L04Rik
Summary
Predicted to enable polypeptide N-acetylgalactosaminyltransferase activity. Predicted to be involved in protein O-linked glycosylation via threonine. Predicted to be active in Golgi apparatus. Is expressed in eye; facial bone primordium; and nervous system. Orthologous to human GALNTL6 (polypeptide N-acetylgalactosaminyltransferase like 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 2.7), frontal lobe adult (RPKM 1.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Galntl6 in Genome Data Viewer
Location:
8 B2; 8 30.72 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (58225523..59366213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (57772489..58912531, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:60058653-60058919 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 7 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_21537 Neighboring gene expressed sequence AW046200 Neighboring gene STARR-seq mESC enhancer starr_21540 Neighboring gene STARR-positive B cell enhancer ABC_E5007 Neighboring gene STARR-seq mESC enhancer starr_21544 Neighboring gene predicted gene 2921 Neighboring gene STARR-seq mESC enhancer starr_21547 Neighboring gene STARR-seq mESC enhancer starr_21548 Neighboring gene predicted gene 15881 Neighboring gene predicted gene, 57526 Neighboring gene STARR-seq mESC enhancer starr_21549 Neighboring gene STARR-seq mESC enhancer starr_21550 Neighboring gene cDNA sequence BC030500 Neighboring gene RuvB-like protein 1 pseudogene Neighboring gene 3-phosphoglycerate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Peng C, et al. Biochem Biophys Res Commun, 2010 Nov 26. PMID 20977886
  2. Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Miller JA, et al. Development, 2013 Nov. PMID 24154525, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables polypeptide N-acetylgalactosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polypeptide N-acetylgalactosaminyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked glycosylation via threonine ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polypeptide N-acetylgalactosaminyltransferase-like 6
Names
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 20
NP_778197.2
XP_017168336.2
XP_030099456.1
XP_036009969.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175032.4 → NP_778197.2  polypeptide N-acetylgalactosaminyltransferase-like 6

    See identical proteins and their annotated locations for NP_778197.2

    Status: VALIDATED

    Source sequence(s)
    AC116475, AC116825, AC116875, AC134838, AC135357
    Consensus CDS
    CCDS22318.2
    UniProtKB/TrEMBL
    E5D8G1
    Related
    ENSMUSP00000145321.2, ENSMUST00000204128.3
    Conserved Domains (4) summary
    cd02510
    Location:143 → 438
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    cd00161
    Location:456 → 584
    RICIN; Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific ...
    pfam00652
    Location:454 → 582
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain
    pfam10111
    Location:143 → 405
    Glyco_tranf_2_2; Glycosyltransferase like family 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    58225523..59366213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243596.2 → XP_030099456.1  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X2

    Conserved Domains (2) summary
    cd02510
    Location:237 → 472
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:477 → 602
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  2. XM_017312847.3 → XP_017168336.2  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X1

    Conserved Domains (2) summary
    cd02510
    Location:237 → 532
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
    pfam00652
    Location:548 → 676
    Ricin_B_lectin; Ricin-type beta-trefoil lectin domain

  3. XM_036154076.1 → XP_036009969.1  polypeptide N-acetylgalactosaminyltransferase-like 6 isoform X3

    Conserved Domains (1) summary
    cd02510
    Location:237 → 532
    pp-GalNAc-T; pp-GalNAc-T initiates the formation of mucin-type O-linked glycans
Nucleotide Protein Strain
Heading Accession and Version

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