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GPR160 G protein-coupled receptor 160 [ Homo sapiens (human) ]

Gene ID: 26996, updated on 5-Mar-2024

Summary

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Official Symbol
GPR160provided by HGNC
Official Full Name
G protein-coupled receptor 160provided by HGNC
Primary source
HGNC:HGNC:23693
See related
Ensembl:ENSG00000173890 AllianceGenome:HGNC:23693
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPCR1; GPCR150
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Located in plasma membrane. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in small intestine (RPKM 20.7), duodenum (RPKM 16.2) and 15 other tissues See more
Orthologs
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Genomic context

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Location:
3q26.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (170037995..170085392)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (172822662..172870058)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (169755783..169803180)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20789 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20790 Neighboring gene FHL1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20791 Neighboring gene NANOG hESC enhancer GRCh37_chr3:169686270-169686802 Neighboring gene SEC62 homolog, preprotein translocation factor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14877 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14878 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr3:169756663-169757162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20793 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:169763504-169764004 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20794 Neighboring gene uncharacterized LOC124909455 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20795 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20797 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169773599-169774098 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169779520-169780041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:169780042-169780562 Neighboring gene MPRA-validated peak4913 silencer Neighboring gene RNA, U4 small nuclear 38, pseudogene Neighboring gene uncharacterized LOC124909456 Neighboring gene KMT5A pseudogene 3 Neighboring gene MPRA-validated peak4915 silencer Neighboring gene uncharacterized LOC105374209 Neighboring gene polyhomeotic homolog 3 Neighboring gene RNA, U6 small nuclear 315, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. GPR160 is a potential biomarker associated with prostate cancer. Guo W, et al. Signal Transduct Target Ther, 2021 Jun 25. PMID 34168114, Free PMC Article
  2. Mining of assembled expressed sequence tag (EST) data for protein families: application to the G protein-coupled receptor superfamily. Conklin D, et al. Brief Bioinform, 2000 Feb. PMID 11466977
  3. G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells. Zhou C, et al. Oncotarget, 2016 Mar 15. PMID 26871479, Free PMC Article
  4. G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK. Yang H, et al. Cell Signal, 2016 Sep. PMID 27259691
  5. Identification of G protein-coupled receptor genes from the human genome sequence. Takeda S, et al. FEBS Lett, 2002 Jun 5. PMID 12044878

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR160 is a potential biomarker associated with prostate cancer.
    Title: GPR160 is a potential biomarker associated with prostate cancer.
  2. Our data suggest that the expression level of endogenous GPR160 is associated with the pathogenesis of prostate cancer
    Title: G protein-coupled receptor GPR160 is associated with apoptosis and cell cycle arrest of prostate cancer cells.
  3. these findings suggest an important role of GPR160 in regulating the entry of BCG into macrophages by targeting the ERK signaling pathway.
    Title: G protein-coupled receptor160 regulates mycobacteria entry into macrophages by activating ERK.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Association of genetic variants with hemorrhagic stroke in Japanese individuals.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
probable G-protein coupled receptor 160
Names
G-protein coupled receptor GPCR1
hGPCR1
putative G protein-coupled receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014373.3 → NP_055188.1  probable G-protein coupled receptor 160

    See identical proteins and their annotated locations for NP_055188.1

    Status: VALIDATED

    Source sequence(s)
    AI560646, BC000181, BX400356, BX414005
    Consensus CDS
    CCDS3211.1
    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42
    Related
    ENSP00000348161.5, ENST00000355897.10

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    170037995..170085392
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453450.2 → XP_024309218.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  2. XM_024453449.2 → XP_024309217.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  3. XM_005247346.5 → XP_005247403.1  probable G-protein coupled receptor 160 isoform X1

    See identical proteins and their annotated locations for XP_005247403.1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  4. XM_017006161.3 → XP_016861650.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  5. XM_047447959.1 → XP_047303915.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  6. XM_005247347.5 → XP_005247404.1  probable G-protein coupled receptor 160 isoform X1

    See identical proteins and their annotated locations for XP_005247404.1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    172822662..172870058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346156.1 → XP_054202131.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  2. XM_054346155.1 → XP_054202130.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  3. XM_054346157.1 → XP_054202132.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42

  4. XM_054346158.1 → XP_054202133.1  probable G-protein coupled receptor 160 isoform X1

    UniProtKB/Swiss-Prot
    D3DNQ2, Q9UJ42
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UJ42.1 GenPept UniProtKB/Swiss-Prot:Q9UJ42

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