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Rnft2 ring finger protein, transmembrane 2 [ Mus musculus (house mouse) ]

Gene ID: 269695, updated on 2-Nov-2024

Summary

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Official Symbol
Rnft2provided by MGI
Official Full Name
ring finger protein, transmembrane 2provided by MGI
Primary source
MGI:MGI:2442859
See related
Ensembl:ENSMUSG00000032850 AllianceGenome:MGI:2442859
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem118; B830028P19Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in positive regulation of ERAD pathway. Predicted to be located in membrane. Is expressed in several structures, including brain; male reproductive gland or organ; parathyroid gland; trachea; and trigeminal nerve. Orthologous to human RNFT2 (ring finger protein, transmembrane 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in whole brain E14.5 (RPKM 9.2), CNS E14 (RPKM 9.0) and 14 other tissues See more
Orthologs
human all
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Genomic context

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See Rnft2 in Genome Data Viewer
Location:
5 F; 5 58.2 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (118328799..118388518, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (118190734..118245510, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_14188 Neighboring gene predicted gene, 30522 Neighboring gene harakiri, BCL2 interacting protein (contains only BH3 domain) Neighboring gene STARR-positive B cell enhancer ABC_E431 Neighboring gene SREBF pathway regulator in golgi 1 Neighboring gene predicted gene, 25076 Neighboring gene STARR-positive B cell enhancer mm9_chr5:118776989-118777289 Neighboring gene STARR-positive B cell enhancer ABC_E10344 Neighboring gene predicted gene, 46942

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RING finger and transmembrane domain-containing protein 2
Names
transmembrane protein 118

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001109902.1 → NP_001103372.1  RING finger and transmembrane domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001103372.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and at a single splice boundary, compared to variant 1, resulting in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AW049082, BC057302, BY721494
    Consensus CDS
    CCDS51632.1
    UniProtKB/Swiss-Prot
    Q3UF64, Q8BXI9
    Related
    ENSMUSP00000113749.2, ENSMUST00000121369.8
    Conserved Domains (1) summary
    cd16742
    Location:384 → 423
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  2. NM_172998.3 → NP_766586.2  RING finger and transmembrane domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_766586.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK046850, AW049082, BU611972
    Consensus CDS
    CCDS19611.2
    UniProtKB/Swiss-Prot
    Q3UF64
    Related
    ENSMUSP00000112903.2, ENSMUST00000117177.8
    Conserved Domains (1) summary
    cd16742
    Location:385 → 424
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    118328799..118388518 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530344.3 → XP_006530407.1  RING finger and transmembrane domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530407.1

    UniProtKB/Swiss-Prot
    Q3UF64
    Conserved Domains (1) summary
    cd16742
    Location:385 → 424
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  2. XM_036165152.1 → XP_036021045.1  RING finger and transmembrane domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    cl17238
    Location:384 → 401
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  3. XM_017320901.2 → XP_017176390.1  RING finger and transmembrane domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UF64, Q8BXI9
    Conserved Domains (1) summary
    cd16742
    Location:384 → 423
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  4. XM_006530347.3 → XP_006530410.1  RING finger and transmembrane domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530410.1

    UniProtKB/Swiss-Prot
    Q3UF64
    Conserved Domains (1) summary
    cd16742
    Location:385 → 424
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  5. XM_006530349.2 → XP_006530412.1  RING finger and transmembrane domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006530412.1

    UniProtKB/Swiss-Prot
    Q3UF64, Q8BXI9
    Conserved Domains (1) summary
    cd16742
    Location:384 → 423
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  6. XM_006530348.2 → XP_006530411.1  RING finger and transmembrane domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530411.1

    UniProtKB/Swiss-Prot
    Q3UF64
    Conserved Domains (1) summary
    cd16742
    Location:385 → 424
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  7. XM_030254537.1 → XP_030110397.1  RING finger and transmembrane domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UF64, Q8BXI9
    Conserved Domains (1) summary
    cd16742
    Location:384 → 423
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  8. XM_006530345.2 → XP_006530408.1  RING finger and transmembrane domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530408.1

    UniProtKB/Swiss-Prot
    Q3UF64
    Conserved Domains (1) summary
    cd16742
    Location:385 → 424
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  9. XM_036165151.1 → XP_036021044.1  RING finger and transmembrane domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q3UF64, Q8BXI9
    Conserved Domains (1) summary
    cd16742
    Location:384 → 423
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  10. XM_006530346.5 → XP_006530409.1  RING finger and transmembrane domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006530409.1

    UniProtKB/Swiss-Prot
    Q3UF64
    Conserved Domains (1) summary
    cd16742
    Location:385 → 424
    RING-HC_RNFT2; RING finger, HC subclass, found in RING finger and transmembrane domain-containing protein 2(RNFT2)

  11. XM_006530350.3 → XP_006530413.1  RING finger and transmembrane domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    cl17238
    Location:385 → 402
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  12. XM_030254539.1 → XP_030110399.1  RING finger and transmembrane domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    D3Z0I9

  13. XM_030254540.2 → XP_030110400.1  RING finger and transmembrane domain-containing protein 2 isoform X6

    UniProtKB/TrEMBL
    D3Z0I9

  14. XM_030254538.2 → XP_030110398.1  RING finger and transmembrane domain-containing protein 2 isoform X5

    UniProtKB/TrEMBL
    D3Z0I9
    Related
    ENSMUSP00000120260.2, ENSMUST00000154786.8

RNA

  1. XR_878686.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UF64.2 GenPept UniProtKB/Swiss-Prot:Q3UF64

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