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Lhfpl3 lipoma HMGIC fusion partner-like 3 [ Mus musculus (house mouse) ]

Gene ID: 269629, updated on 2-Nov-2024

Summary

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Official Symbol
Lhfpl3provided by MGI
Official Full Name
lipoma HMGIC fusion partner-like 3provided by MGI
Primary source
MGI:MGI:1925076
See related
Ensembl:ENSMUSG00000106379 AllianceGenome:MGI:1925076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A930031L14Rik
Summary
Predicted to be involved in sensory perception of sound. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain and reproductive system. Orthologous to human LHFPL3 (LHFPL tetraspan subfamily member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in frontal lobe adult (RPKM 9.6), cerebellum adult (RPKM 7.7) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Lhfpl3 in Genome Data Viewer
Location:
5 A3; 5 10.07 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (22951052..23480595)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (22746054..23275597)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930003O13 gene Neighboring gene predicted gene, 32711 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-seq mESC enhancer starr_12595 Neighboring gene predicted pseudogene 6564 Neighboring gene STARR-positive B cell enhancer mm9_chr5:22666753-22667054 Neighboring gene STARR-seq mESC enhancer starr_12596 Neighboring gene macrophage migration inhibitory factor, pseudogene 12 Neighboring gene STARR-seq mESC enhancer starr_12597 Neighboring gene STARR-seq mESC enhancer starr_12598 Neighboring gene STARR-seq mESC enhancer starr_12600 Neighboring gene SPATA31 subfamily H member 2 Neighboring gene STARR-seq mESC enhancer starr_12601 Neighboring gene STARR-seq mESC enhancer starr_12603 Neighboring gene RIKEN cDNA 5031425E22 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:22892703-22893070 Neighboring gene STARR-seq mESC enhancer starr_12606 Neighboring gene STARR-seq mESC enhancer starr_12607 Neighboring gene STARR-positive B cell enhancer ABC_E1297 Neighboring gene STARR-positive B cell enhancer ABC_E528 Neighboring gene lysine (K)-specific methyltransferase 2E

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells. Qiu X, et al. Cell Rep, 2023 Mar 28. PMID 36917610, Free PMC Article
  2. Novel function of LHFPL2 in female and male distal reproductive tract development. Zhao F, et al. Sci Rep, 2016 Mar 11. PMID 26964900, Free PMC Article
  3. A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice. Longo-Guess CM, et al. Proc Natl Acad Sci U S A, 2005 May 31. PMID 15905332, Free PMC Article
  4. Expression of metanephric nephron-patterning genes in differentiating mesonephric tubules. Georgas KM, et al. Dev Dyn, 2011 Jun. PMID 21491542, Free PMC Article
  5. Overlapping Activities of Two Neuronal Splicing Factors Switch the GABA Effect from Excitatory to Inhibitory by Regulating REST. Nakano Y, et al. Cell Rep, 2019 Apr 16. PMID 30995482, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The authors present an overview of the Lhfp gene family in mouse and humans.
    Title: A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in sensory perception of sound IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LHFPL tetraspan subfamily member 3 protein
Names
lipoma HMGIC fusion partner-like 3 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081231.3 → NP_001074700.2  LHFPL tetraspan subfamily member 3 protein isoform 2

    See identical proteins and their annotated locations for NP_001074700.2

    Status: VALIDATED

    Source sequence(s)
    AC123661, AC138737, AC158942
    Consensus CDS
    CCDS80218.1
    UniProtKB/Swiss-Prot
    Q9CTN8
    UniProtKB/TrEMBL
    A0A0G2JGI3
    Related
    ENSMUSP00000143576.2, ENSMUST00000197992.2
    Conserved Domains (1) summary
    pfam10242
    Location:32 → 209
    L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

  2. NM_001359998.2 → NP_001346927.1  LHFPL tetraspan subfamily member 3 protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC123661, AC138737, AC158942
    Consensus CDS
    CCDS80218.1
    UniProtKB/Swiss-Prot
    Q9CTN8
    UniProtKB/TrEMBL
    A0A0G2JGI3
    Conserved Domains (1) summary
    pfam10242
    Location:32 → 209
    L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

  3. NM_029990.2 → NP_084266.1  LHFPL tetraspan subfamily member 3 protein isoform 1

    See identical proteins and their annotated locations for NP_084266.1

    Status: VALIDATED

    Source sequence(s)
    AC123661, AC138737, AC158942
    UniProtKB/Swiss-Prot
    Q9CTN8
    Conserved Domains (1) summary
    pfam10242
    Location:32 → 209
    L_HMGIC_fpl; Lipoma HMGIC fusion partner-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    22951052..23480595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CTN8.2 GenPept UniProtKB/Swiss-Prot:Q9CTN8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials