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Luzp1 leucine zipper protein 1 [ Mus musculus (house mouse) ]

Gene ID: 269593, updated on 14-Nov-2024

Summary

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Official Symbol
Luzp1provided by MGI
Official Full Name
leucine zipper protein 1provided by MGI
Primary source
MGI:MGI:107629
See related
Ensembl:ENSMUSG00000001089 AllianceGenome:MGI:107629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Luzp; mFLJ00226; 2700072H04Rik
Summary
Acts upstream of or within artery development; neural fold bending; and ventricular septum development. Located in nucleus. Is expressed in several structures, including alimentary system; brain; pharyngo-tympanic tube; skin; and submandibular gland primordium. Orthologous to human LUZP1 (leucine zipper protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 24.4), cerebellum adult (RPKM 11.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Luzp1 in Genome Data Viewer
Location:
4 D3; 4 68.8 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (136189892..136282036)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (136462609..136554725)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31295 Neighboring gene 5-hydroxytryptamine (serotonin) receptor 1D Neighboring gene lysine (K)-specific demethylase 1A Neighboring gene STARR-positive B cell enhancer ABC_E6238 Neighboring gene STARR-positive B cell enhancer mm9_chr4:136177240-136177540 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene testis expressed 46 Neighboring gene lactamase, beta-like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction. Yano T, et al. EMBO J, 2021 Jan 15. PMID 33346378, Free PMC Article
  2. LUZP1, a novel regulator of primary cilia and the actin cytoskeleton, is a contributing factor in Townes-Brocks Syndrome. Bozal-Basterra L, et al. Elife, 2020 Jun 18. PMID 32553112, Free PMC Article
  3. Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling. Fan D, et al. J Adv Res, 2024 Sep. PMID 37806546, Free PMC Article
  4. Restricted expression of LUZP in neural lineage cells: a study in embryonic stem cells. Lee MW, et al. J Biomed Sci, 2001 Nov-Dec. PMID 11702014
  5. Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1. Niri F, et al. Biochem Cell Biol, 2021 Dec. PMID 34197713

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling.
    Title: Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling.
  2. Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
    Title: Chromatin remodeling factor CECR2 forms tissue-specific complexes with CCAR2 and LUZP1.
  3. A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction.
    Title: A microtubule-LUZP1 association around tight junction promotes epithelial cell apical constriction.
  4. These findings assign a novel function of LUZP in the embryonic development of brain.
    Title: LUZP deficiency affects neural tube closure during brain development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC169408, MGC169410

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin filament binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in apical constriction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within artery development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in contractile ring contraction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within neural fold bending IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein complex stability IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress fiber assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of CERF complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin filament ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromosome, centromeric region ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle midzone ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in stress fiber ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in tight junction IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
leucine zipper protein 1
Names
leucine zipper motif-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024452.2 → NP_077772.2  leucine zipper protein 1

    See identical proteins and their annotated locations for NP_077772.2

    Status: VALIDATED

    Source sequence(s)
    AK139583, AL671173
    Consensus CDS
    CCDS38923.1
    UniProtKB/Swiss-Prot
    A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
    UniProtKB/TrEMBL
    B2RQ68
    Related
    ENSMUSP00000130758.2, ENSMUST00000170102.8
    Conserved Domains (1) summary
    COG1196
    Location:19 → 354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    136189892..136282036
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253587.2 → XP_030109447.1  leucine zipper protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
    UniProtKB/TrEMBL
    B2RQ68
    Conserved Domains (1) summary
    COG1196
    Location:19 → 354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  2. XM_006538921.3 → XP_006538984.1  leucine zipper protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006538984.1

    UniProtKB/Swiss-Prot
    A3KG96, Q3UV18, Q7TS71, Q8BQW1, Q8R4U7, Q99NG3, Q9CSL6
    UniProtKB/TrEMBL
    B2RQ68
    Related
    ENSMUSP00000101475.3, ENSMUST00000105849.9
    Conserved Domains (1) summary
    COG1196
    Location:19 → 354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

  3. XM_030253588.1 → XP_030109448.1  leucine zipper protein 1 isoform X2

    UniProtKB/TrEMBL
    B2RQ68
    Conserved Domains (1) summary
    COG1196
    Location:19 → 354
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

RNA

  1. XR_390755.2 RNA Sequence

  2. XR_390753.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4U7.2 GenPept UniProtKB/Swiss-Prot:Q8R4U7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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