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Fbxo10 F-box protein 10 [ Mus musculus (house mouse) ]

Gene ID: 269529, updated on 18-Sep-2024

Summary

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Official Symbol
Fbxo10provided by MGI
Official Full Name
F-box protein 10provided by MGI
Primary source
MGI:MGI:2686937
See related
Ensembl:ENSMUSG00000048232 AllianceGenome:MGI:2686937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBX10; Gm634
Summary
Predicted to be involved in protein ubiquitination; regulation of apoptotic process; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within apoptotic process. Predicted to be located in cytoplasm. Orthologous to human FBXO10 (F-box protein 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 21.2), ovary adult (RPKM 16.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Fbxo10 in Genome Data Viewer
Location:
4 B1; 4 23.68 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45034248..45084555, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45034248..45084604, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71 Neighboring gene STARR-seq mESC enhancer starr_10090 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene polymerase (RNA) I polypeptide E Neighboring gene predicted gene, 30939 Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene FERM and PDZ domain containing 1, opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice. Masle-Farquhar E, et al. PLoS One, 2021. PMID 33914737, Free PMC Article
  2. Signaling complexes of the FERM domain-containing protein GRSP1 bound to ARF exchange factor GRP1. Klarlund JK, et al. J Biol Chem, 2001 Oct 26. PMID 11445584
  3. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice.
    Title: Loss-of-function of Fbxo10, encoding a post-translational regulator of BCL2 in lymphomas, has no discernible effect on BCL2 or B lymphocyte accumulation in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6)  1 citation
  • Targeted (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box only protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024142.2 → NP_001019313.1  F-box only protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001019313.1

    Status: VALIDATED

    Source sequence(s)
    AL824706
    Consensus CDS
    CCDS51171.1
    UniProtKB/Swiss-Prot
    A2ANI6, Q6AXG0, Q7TQF2, Q7TQM0
    UniProtKB/TrEMBL
    Q505G2
    Related
    ENSMUSP00000058233.7, ENSMUST00000052236.13
    Conserved Domains (2) summary
    pfam12937
    Location:6 → 50
    F-box-like; F-box-like
    pfam13229
    Location:460 → 606
    Beta_helix; Right handed beta helix region

  2. NM_001378819.1 → NP_001365748.1  F-box only protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL824706
    Conserved Domains (2) summary
    pfam12937
    Location:6 → 49
    F-box-like
    pfam13229
    Location:460 → 616
    Beta_helix; Right handed beta helix region

  3. NM_001378820.1 → NP_001365749.1  F-box only protein 10 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL824706
    Conserved Domains (1) summary
    pfam13229
    Location:273 → 419
    Beta_helix; Right handed beta helix region

  4. NM_001378821.1 → NP_001365750.1  F-box only protein 10 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL824706
    Conserved Domains (2) summary
    pfam12937
    Location:6 → 49
    F-box-like
    pfam13229
    Location:460 → 606
    Beta_helix; Right handed beta helix region

  5. NM_001378822.1 → NP_001365751.1  F-box only protein 10 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL824706
    Conserved Domains (2) summary
    pfam12937
    Location:6 → 49
    F-box-like
    pfam13229
    Location:460 → 616
    Beta_helix; Right handed beta helix region

  6. NM_001378823.1 → NP_001365752.1  F-box only protein 10 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL824706
    UniProtKB/TrEMBL
    Q505G2
    Related
    ENSMUSP00000119862.2, ENSMUST00000140008.2
    Conserved Domains (1) summary
    pfam13229
    Location:273 → 419
    Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    45034248..45084555 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQF2.2 GenPept UniProtKB/Swiss-Prot:Q7TQF2

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