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Plch1 phospholipase C, eta 1 [ Mus musculus (house mouse) ]

Gene ID: 269437, updated on 2-Nov-2024

Summary

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Official Symbol
Plch1provided by MGI
Official Full Name
phospholipase C, eta 1provided by MGI
Primary source
MGI:MGI:2683547
See related
Ensembl:ENSMUSG00000036834 AllianceGenome:MGI:2683547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Plcl3; PLCeta1; PLC-eta-1
Summary
Predicted to enable calcium-dependent phospholipase C activity and phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Located in cytosol and membrane. Is expressed in intestine; musculoskeletal system; nervous system; and neural retina. Human ortholog(s) of this gene implicated in holoprosencephaly. Orthologous to human PLCH1 (phospholipase C eta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 3.5), whole brain E14.5 (RPKM 2.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Plch1 in Genome Data Viewer
Location:
3 E1; 3 30.08 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (63603620..63806929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (63696199..63899503, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34240 Neighboring gene STARR-seq mESC enhancer starr_07833 Neighboring gene small transmembrane regulator of ion transport 1 Neighboring gene STARR-seq mESC enhancer starr_07834 Neighboring gene STARR-seq mESC enhancer starr_07835 Neighboring gene STARR-seq mESC enhancer starr_07836 Neighboring gene STARR-seq mESC enhancer starr_07837 Neighboring gene RIKEN cDNA E130311K13 gene Neighboring gene predicted gene, 34379

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phospholipase C-η1 is activated by intracellular Ca(2+) mobilization and enhances GPCRs/PLC/Ca(2+) signaling. Kim JK, et al. Cell Signal, 2011 Jun. PMID 21262355
  2. Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice. Dzhura I, et al. J Physiol, 2010 Dec 15. PMID 21041529, Free PMC Article
  3. Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes. Stewart AJ, et al. Int J Mol Med, 2005 Jan. PMID 15583837
  4. Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy. Zhang L, et al. Cell, 2013 Mar 28. PMID 23540699, Free PMC Article
  5. Molecular cloning and characterization of a novel phospholipase C, PLC-eta. Hwang JI, et al. Biochem J, 2005 Jul 1. PMID 15702972, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Study concludes that perinuclear PLCepsilon, scaffolded to mAKAP in cardiac myocytes, responds to hypertrophic stimuli to generate diacylglycerol (DAG) from PI4P in the Golgi apparatus, in close proximity to the nuclear envelope, to regulate activation of nuclear PKD and hypertrophic signaling pathways.
    Title: Phospholipase Cε hydrolyzes perinuclear phosphatidylinositol 4-phosphate to regulate cardiac hypertrophy.
  2. Phospholipase C-eta was found to be expressed in mouse beta-cells, and knockout of that gene disrupts the action of exendin-4 to facilitate calcium-induced calcium release in the beta-cells of these mice.
    Title: Epac2-dependent mobilization of intracellular Ca²+ by glucagon-like peptide-1 receptor agonist exendin-4 is disrupted in β-cells of phospholipase C-ε knockout mice.
  3. PLC-eta1 is activated via intracellular calcium mobilization from the endoplasmic reticulum, and therefore amplifies G-protein coupled receptor mediated signaling
    Title: Phospholipase C-η1 is activated by intracellular Ca(2+) mobilization and enhances GPCRs/PLC/Ca(2+) signaling.
  4. The identification of a novel PLC isoform in the brains of human and mouse, named PLC-eta, which contains the conserved pleckstrin homology domain, X and Y domains for catalytic activity and the C2 domain.
    Title: Molecular cloning and characterization of a novel phospholipase C, PLC-eta.
  5. molecular cloning of PLC-eta1 and PLC-eta2.
    Title: Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC57096

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium-dependent phospholipase C activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1
Names
phosphoinositide phospholipase C-eta-1
phospholipase C-like protein 3
NP_001171203.1
NP_001171204.1
NP_001357913.1
NP_001357914.1
NP_899014.2
XP_006501593.1
XP_006501594.1
XP_006501596.1
XP_006501598.1
XP_006501599.1
XP_006501601.1
XP_006501604.1
XP_011238433.1
XP_011238435.1
XP_011238436.1
XP_017175082.1
XP_017175083.1
XP_017175084.1
XP_017175085.1
XP_017175087.1
XP_017175088.1
XP_017175089.1
XP_017175090.1
XP_030108492.1
XP_030108493.1
XP_036019019.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177732.2 → NP_001171203.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 3

    See identical proteins and their annotated locations for NP_001171203.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3, also known as PLC-eta1a) differs in the 3' UTR and includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. This results in an isoform (3, also known as phospholipase C-eta1a) that has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC116732, AC121285
    Consensus CDS
    CCDS57215.1
    UniProtKB/TrEMBL
    H3BKE1
    Related
    ENSMUSP00000124463.3, ENSMUST00000162269.9
    Conserved Domains (7) summary
    cd00275
    Location:732 → 856
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 702
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441 → 542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain

  2. NM_001177733.2 → NP_001171204.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 2

    See identical proteins and their annotated locations for NP_001171204.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also known as PLC-eta1b) includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. This results in an isoform (2, also known as phospholipase C-eta1b) that has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC116732, AC121285
    Consensus CDS
    CCDS50918.1
    UniProtKB/TrEMBL
    H3BKE1
    Related
    ENSMUSP00000124632.3, ENSMUST00000159676.9
    Conserved Domains (7) summary
    cd00275
    Location:732 → 856
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 702
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441 → 542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain

  3. NM_001370984.1 → NP_001357913.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116732, AC121285
    UniProtKB/TrEMBL
    I1E4X4
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  4. NM_001370985.1 → NP_001357914.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116732, AC121285
    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:731 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:146 → 175
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:146 → 286
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain

  5. NM_183191.4 → NP_899014.2  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform 1

    See identical proteins and their annotated locations for NP_899014.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also known as PLC-eta1c) encodes the longest isoform (1, also known as phospholipase C-eta1c).
    Source sequence(s)
    AC116732, AC121285
    Consensus CDS
    CCDS38444.2
    UniProtKB/Swiss-Prot
    Q4KWH5, Q4KWH6, Q4KWH7, Q69ZS3, Q7TPQ1, Q8CFQ2
    UniProtKB/TrEMBL
    I1E4X6
    Related
    ENSMUSP00000081122.6, ENSMUST00000084105.12
    Conserved Domains (7) summary
    cd00275
    Location:732 → 856
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 702
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441 → 542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    63603620..63806929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030252633.2 → XP_030108493.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X10

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  2. XM_006501541.5 → XP_006501604.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X9

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  3. XM_017319596.3 → XP_017175085.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X8

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  4. XM_006501536.5 → XP_006501599.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  5. XM_006501533.5 → XP_006501596.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_006501596.1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  6. XM_017319595.3 → XP_017175084.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X6

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:690 → 814
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 660
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  7. XM_006501535.5 → XP_006501598.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  8. XM_006501530.5 → XP_006501593.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_006501593.1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  9. XM_011240131.4 → XP_011238433.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_011238433.1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  10. XM_017319593.3 → XP_017175082.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  11. XM_006501531.5 → XP_006501594.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    See identical proteins and their annotated locations for XP_006501594.1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  12. XM_017319594.1 → XP_017175083.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (4) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  13. XM_011240134.3 → XP_011238436.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

    See identical proteins and their annotated locations for XP_011238436.1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (2) summary
    cd08632
    Location:115 → 519
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:44 → 659
    PLN02228; Phosphoinositide phospholipase C

  14. XM_011240133.3 → XP_011238435.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X7

    See identical proteins and their annotated locations for XP_011238435.1

    UniProtKB/TrEMBL
    I1E4X6
    Conserved Domains (2) summary
    cd08632
    Location:115 → 519
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:44 → 659
    PLN02228; Phosphoinositide phospholipase C

  15. XM_017319600.3 → XP_017175089.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X13

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02230
    Location:285 → 853
    PLN02230; phosphoinositide phospholipase C 4
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  16. XM_017319601.3 → XP_017175090.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X14

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  17. XM_017319599.3 → XP_017175088.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X12

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  18. XM_006501538.5 → XP_006501601.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X4

    UniProtKB/TrEMBL
    H3BKK4, I1E4X4
    Related
    ENSMUSP00000135424.2, ENSMUST00000177143.8
    Conserved Domains (4) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  19. XM_017319598.3 → XP_017175087.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X11

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:744 → 868
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 714
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  20. XM_036163126.1 → XP_036019019.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X15

    UniProtKB/TrEMBL
    H3BKE1
    Conserved Domains (5) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd15898
    Location:158 → 187
    EFh_PI-PLC; EF-hand motif [structural motif]
    cl28895
    Location:158 → 298
    EFh_PI-PLC; EF-hand motif found in eukaryotic phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11) isozymes
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  21. XM_030252632.2 → XP_030108492.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X5

    UniProtKB/TrEMBL
    I1E4X4
    Conserved Domains (4) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    cd16220
    Location:158 → 298
    EFh_PI-PLCeta1; EF-hand motif found in phosphoinositide phospholipase C eta 1 (PI-PLC-eta1)
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KWH5.1 GenPept UniProtKB/Swiss-Prot:Q4KWH5

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