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Mecr mitochondrial trans-2-enoyl-CoA reductase [ Mus musculus (house mouse) ]

Gene ID: 26922, updated on 3-Nov-2024

Summary

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Official Symbol
Mecrprovided by MGI
Official Full Name
mitochondrial trans-2-enoyl-CoA reductaseprovided by MGI
Primary source
MGI:MGI:1349441
See related
Ensembl:ENSMUSG00000028910 AllianceGenome:MGI:1349441
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nrbf1; NRBF-1
Summary
Predicted to enable enoyl-[acyl-carrier-protein] reductase (NADPH) activity; nuclear receptor binding activity; and signaling receptor binding activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. Is expressed in submandibular gland primordium. Human ortholog(s) of this gene implicated in childhood-onset dystonia with optic atrophy and basal ganglia abnormalities and optic atrophy. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 11.0), colon adult (RPKM 9.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Mecr in Genome Data Viewer
Location:
4 D2.3; 4 64.52 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (131570755..131595097)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (131843444..131867787)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11548 Neighboring gene predicted gene, 42321 Neighboring gene protein tyrosine phosphatase receptor type U Neighboring gene predicted gene, 52680 Neighboring gene STARR-positive B cell enhancer ABC_E10262 Neighboring gene serine and arginine-rich splicing factor 4 Neighboring gene predicted gene 12992 Neighboring gene phosphatidylinositol 3-kinase, catalytic, beta polypeptide pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance. Qian S, et al. Biosci Rep, 2020 Jun 26. PMID 32440681, Free PMC Article
  2. Impaired Mitochondrial Fatty Acid Synthesis Leads to Neurodegeneration in Mice. Nair RR, et al. J Neurosci, 2018 Nov 7. PMID 30266742, Free PMC Article
  3. Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse. Chen Z, et al. PLoS One, 2009. PMID 19440339, Free PMC Article
  4. Structural enzymological studies of 2-enoyl thioester reductase of the human mitochondrial FAS II pathway: new insights into its substrate recognition properties. Chen ZJ, et al. J Mol Biol, 2008 Jun 13. PMID 18479707
  5. Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Nair RR, et al. Hum Mol Genet, 2017 Jun 1. PMID 28369354

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance.
    Title: ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance.
  2. The results showed a ventricular dilatation behind impaired heart function upon Mecr overexpression, concurrent with appearance of dysmorphic mitochondria
    Title: Myocardial overexpression of Mecr, a gene of mitochondrial FAS II leads to cardiac dysfunction in mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (5)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
  
enables enoyl-[acyl-carrier-protein] reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of intracellular iron ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
enoyl-[acyl-carrier-protein] reductase, mitochondrial
Names
2-enoyl thioester reductase
nuclear receptor binding factor 1
trans-2-enoyl-CoA reductase, mitochondrial
NP_001411880.1
NP_001411881.1
NP_001411882.1
NP_001411883.1
NP_001411884.1
NP_079573.2
XP_006538952.1
XP_011248563.1
XP_011248564.1
XP_011248565.1
XP_036020030.1
XP_036020031.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424951.1 → NP_001411880.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959

  2. NM_001424952.1 → NP_001411881.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959

  3. NM_001424953.1 → NP_001411882.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959

  4. NM_001424954.1 → NP_001411883.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959

  5. NM_001424955.1 → NP_001411884.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959

  6. NM_025297.3 → NP_079573.2  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform 2 precursor

    See identical proteins and their annotated locations for NP_079573.2

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959
    Consensus CDS
    CCDS18715.1
    UniProtKB/Swiss-Prot
    Q99L39, Q9DCS3
    Related
    ENSMUSP00000030742.5, ENSMUST00000030742.11
    Conserved Domains (2) summary
    cd08290
    Location:44 → 373
    ETR; 2-enoyl thioester reductase (ETR)
    COG0604
    Location:44 → 350
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RNA

  1. NR_188987.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959

  2. NR_188988.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL607088, AL670959

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    131570755..131595097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250261.2 → XP_011248563.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011248563.1

    Conserved Domains (1) summary
    cd08290
    Location:22 → 336
    ETR; 2-enoyl thioester reductase (ETR)

  2. XM_036164138.1 → XP_036020031.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd08290
    Location:1 → 297
    ETR; 2-enoyl thioester reductase (ETR)

  3. XM_036164137.1 → XP_036020030.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X3

    Conserved Domains (1) summary
    cd08290
    Location:1 → 297
    ETR; 2-enoyl thioester reductase (ETR)

  4. XM_006538889.3 → XP_006538952.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006538952.1

    Conserved Domains (1) summary
    cd08290
    Location:22 → 336
    ETR; 2-enoyl thioester reductase (ETR)

  5. XM_011250262.2 → XP_011248564.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011248564.1

    Conserved Domains (1) summary
    cd08290
    Location:22 → 336
    ETR; 2-enoyl thioester reductase (ETR)

  6. XM_011250263.2 → XP_011248565.1  enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011248565.1

    Conserved Domains (1) summary
    cd08290
    Location:22 → 336
    ETR; 2-enoyl thioester reductase (ETR)

RNA

  1. XR_001784149.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DCS3.2 GenPept UniProtKB/Swiss-Prot:Q9DCS3

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