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Cntrl centriolin [ Mus musculus (house mouse) ]

Gene ID: 26920, updated on 2-Nov-2024

Summary

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Official Symbol
Cntrlprovided by MGI
Official Full Name
centriolinprovided by MGI
Primary source
MGI:MGI:1889576
See related
Ensembl:ENSMUSG00000057110 AllianceGenome:MGI:1889576
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cep1; IB3/5; Ma2a8; Cep110; b2b1468Clo; b2b1468.1Clo; 6720467O09Rik
Summary
Predicted to enable dynein complex binding activity. Acts upstream of or within circulatory system development; female germ-line stem cell asymmetric division; and kidney development. Located in meiotic spindle pole; mitotic spindle pole; and perinuclear region of cytoplasm. Is expressed in cerebral cortex ventricular layer; midbrain ventricular layer; and telencephalon ventricular layer. Used to study nephronophthisis. Orthologous to human CNTRL (centriolin). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.2), thymus adult (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cntrl in Genome Data Viewer
Location:
2 B; 2 23.36 cM
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (34999504..35068834)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (35109476..35178822)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene hemolytic complement Neighboring gene STARR-seq mESC enhancer starr_04276 Neighboring gene predicted gene, 39794 Neighboring gene expressed sequence AI182371 Neighboring gene STARR-positive B cell enhancer ABC_E4440 Neighboring gene STARR-positive B cell enhancer ABC_E2616 Neighboring gene STARR-positive B cell enhancer ABC_E5906 Neighboring gene RAB14, member RAS oncogene family Neighboring gene STARR-positive B cell enhancer ABC_E7811 Neighboring gene predicted gene 13605 Neighboring gene predicted gene, 52553

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Centriolin, a centriole-appendage protein, regulates peripheral spindle migration and asymmetric division in mouse meiotic oocytes. Sun TY, et al. Cell Cycle, 2017 Oct 2. PMID 28075662, Free PMC Article
  2. Molecular cloning of a cDNA encoding an antigen which is salt-stably attached to centrosomes. Angiolillo A, et al. Biochim Biophys Acta, 1996 Dec 11. PMID 8982254
  3. Assignment of the centrosomal protein 110 gene (Cep110) to mouse chromosome bands 2B-C1 by in situ hybridization. Popovici C, et al. Cytogenet Cell Genet, 2000. PMID 10965126
  4. Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models. Ren M, et al. Blood, 2013 Aug 8. PMID 23777766, Free PMC Article
  5. Planar cell polarity induces local microtubule bundling for coordinated ciliary beating. Nakayama S, et al. J Cell Biol, 2021 Jul 5. PMID 33929515, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Centriolin depletion affects spindle size and peripheral spindle migration in oocytes.
    Title: Centriolin, a centriole-appendage protein, regulates peripheral spindle migration and asymmetric division in mouse meiotic oocytes.
  2. CNTRL and FGFR1 have roles in myeloid and lymphoid malignancies in both human and mouse models
    Title: Dysregulated signaling pathways in the development of CNTRL-FGFR1-induced myeloid and lymphoid malignancies associated with FGFR1 in human and mouse models.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables dynein complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aorta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within female germ-line stem cell asymmetric division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within ventricular septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Flemming body IEA
Inferred from Electronic Annotation
more info
  
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriolar satellite IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
part_of centriolar subdistal appendage IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in meiotic spindle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in meiotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitotic spindle pole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
centriolin
Names
110 kDa centrosomal protein
antigen identified by monoclonal antibody 2A8
centrosomal protein 110
centrosomal protein of 110 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290635.1 → NP_001277564.1  centriolin isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 5' and 3' exons but contains alternate 5' and 3' terminal exons, and it thus differs in both UTRs, initiates translation at a downstream in-frame start codon, and differs in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus and has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    BC060146, BY032373
    UniProtKB/TrEMBL
    A2AS42
    Related
    ENSMUSP00000108656.3, ENSMUST00000113033.6
    Conserved Domains (1) summary
    pfam01496
    Location:173 → 259
    V_ATPase_I; V-type ATPase 116kDa subunit family

  2. NM_001379274.1 → NP_001366203.1  centriolin isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL773523, AL845534
    UniProtKB/Swiss-Prot
    A0A4W6, A0A4X1, A2AL36, A2AL37, A2AL40, Q6KAR8, Q8CHX3, Q9CRM3
    UniProtKB/TrEMBL
    B2RXX1
    Related
    ENSMUSP00000028237.9, ENSMUST00000028237.15
    Conserved Domains (6) summary
    COG1196
    Location:440 → 1134
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1407 → 2216
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100 → 119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:1239 → 1310
    Drf_FH1; Formin Homology Region 1
    cd21340
    Location:89 → 261
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. NM_001379275.1 → NP_001366204.1  centriolin isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL773523, AL845534
    Conserved Domains (3) summary
    COG1196
    Location:2 → 581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:854 → 1663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686 → 757
    Drf_FH1; Formin Homology Region 1

  4. NM_012018.2 → NP_036148.2  centriolin isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL773523, AL845534
    Consensus CDS
    CCDS57170.2
    UniProtKB/TrEMBL
    B2RXX1, R4GML3
    Related
    ENSMUSP00000108655.3, ENSMUST00000113032.8
    Conserved Domains (9) summary
    COG1196
    Location:440 → 1133
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00116
    Location:86 → 228
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    pfam14580
    Location:83 → 279
    LRR_9; Leucine-rich repeat
    TIGR02168
    Location:1406 → 2215
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100 → 119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:1238 → 1309
    Drf_FH1; Formin Homology Region 1
    pfam07851
    Location:1955 → 2046
    TMPIT; TMPIT-like protein
    pfam12799
    Location:148 → 185
    LRR_4; Leucine Rich repeats (2 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    34999504..35068834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030251616.2 → XP_030107476.1  centriolin isoform X2

    UniProtKB/TrEMBL
    B2RXX1
    Conserved Domains (5) summary
    COG1196
    Location:287 → 981
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1254 → 2063
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:18 → 41
    LRR_1; leucine-rich repeat [structural motif]
    pfam06346
    Location:1086 → 1157
    Drf_FH1; Formin Homology Region 1
    pfam14580
    Location:8 → 126
    LRR_9; Leucine-rich repeat

  2. XM_006498069.4 → XP_006498132.1  centriolin isoform X1

    UniProtKB/TrEMBL
    B2RXX1
    Conserved Domains (8) summary
    PHA02562
    Location:304 → 538
    46; endonuclease subunit; Provisional
    COG1196
    Location:440 → 1134
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1407 → 2214
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100 → 119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:1239 → 1310
    Drf_FH1; Formin Homology Region 1
    pfam14580
    Location:152 → 279
    LRR_9; Leucine-rich repeat
    pfam12799
    Location:126 → 167
    LRR_4; Leucine Rich repeats (2 copies)

  3. XM_036162232.1 → XP_036018125.1  centriolin isoform X3

    UniProtKB/TrEMBL
    B2RXX1
    Conserved Domains (6) summary
    COG1196
    Location:440 → 1134
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1407 → 2083
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00031
    Location:100 → 119
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:127 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    pfam06346
    Location:1239 → 1310
    Drf_FH1; Formin Homology Region 1
    cd21340
    Location:89 → 261
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  4. XM_030251617.2 → XP_030107477.1  centriolin isoform X4

    UniProtKB/TrEMBL
    B2RXX1
    Conserved Domains (3) summary
    COG1196
    Location:44 → 738
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:1011 → 1820
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:843 → 914
    Drf_FH1; Formin Homology Region 1

  5. XM_036162235.1 → XP_036018128.1  centriolin isoform X8

    Conserved Domains (3) summary
    COG1196
    Location:2 → 580
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:853 → 1660
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:685 → 756
    Drf_FH1; Formin Homology Region 1

  6. XM_030251620.2 → XP_030107480.1  centriolin isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:2 → 581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:854 → 1663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686 → 757
    Drf_FH1; Formin Homology Region 1

  7. XM_006498073.5 → XP_006498136.1  centriolin isoform X5

    See identical proteins and their annotated locations for XP_006498136.1

    Conserved Domains (3) summary
    COG1196
    Location:2 → 581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:854 → 1663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686 → 757
    Drf_FH1; Formin Homology Region 1

  8. XM_006498074.5 → XP_006498137.1  centriolin isoform X5

    See identical proteins and their annotated locations for XP_006498137.1

    Conserved Domains (3) summary
    COG1196
    Location:2 → 581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:854 → 1663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686 → 757
    Drf_FH1; Formin Homology Region 1

  9. XM_036162233.1 → XP_036018126.1  centriolin isoform X6

    UniProtKB/TrEMBL
    E9Q9E7
    Related
    ENSMUSP00000108660.4, ENSMUST00000113037.10
    Conserved Domains (3) summary
    COG1196
    Location:2 → 580
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:853 → 1662
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:685 → 756
    Drf_FH1; Formin Homology Region 1

  10. XM_006498075.5 → XP_006498138.1  centriolin isoform X5

    See identical proteins and their annotated locations for XP_006498138.1

    Conserved Domains (3) summary
    COG1196
    Location:2 → 581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:854 → 1663
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686 → 757
    Drf_FH1; Formin Homology Region 1

  11. XM_036162234.1 → XP_036018127.1  centriolin isoform X7

    Conserved Domains (3) summary
    COG1196
    Location:2 → 581
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02168
    Location:854 → 1661
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06346
    Location:686 → 757
    Drf_FH1; Formin Homology Region 1

RNA

  1. XR_004940615.1 RNA Sequence

  2. XR_004940616.1 RNA Sequence

  3. XR_004940618.1 RNA Sequence

  4. XR_004940617.1 RNA Sequence

  5. XR_004940619.1 RNA Sequence

  6. XR_866015.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_030000.2: Suppressed sequence

    Description
    NM_030000.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2AL36.2 GenPept UniProtKB/Swiss-Prot:A2AL36

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