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Exo1 exonuclease 1 [ Mus musculus (house mouse) ]

Gene ID: 26909, updated on 2-Nov-2024

Summary

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Official Symbol
Exo1provided by MGI
Official Full Name
exonuclease 1provided by MGI
Primary source
MGI:MGI:1349427
See related
Ensembl:ENSMUSG00000039748 AllianceGenome:MGI:1349427
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Msa; 5730442G03Rik
Summary
Enables chromatin binding activity. Acts upstream of or within humoral immune response mediated by circulating immunoglobulin; isotype switching; and somatic hypermutation of immunoglobulin genes. Predicted to be located in nuclear body and plasma membrane. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb segment; and nose. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E11.5 (RPKM 5.1), liver E14 (RPKM 3.6) and 11 other tissues See more
Orthologs
human all
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Genomic context

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See Exo1 in Genome Data Viewer
Location:
1 H4; 1 81.9 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (175708334..175738962)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (175880768..175911396)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain 64 Neighboring gene predicted gene, 25560 Neighboring gene STARR-positive B cell enhancer ABC_E5861 Neighboring gene predicted gene, 36360 Neighboring gene predicted gene, 23805 Neighboring gene beclin 2 Neighboring gene phospholipase D family member 5 Neighboring gene RNA binding motif protein 8A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice. Wang S, et al. Nucleic Acids Res, 2022 Aug 12. PMID 35849338, Free PMC Article
  2. Involvement of Exo1b in DNA damage-induced apoptosis. Bolderson E, et al. Nucleic Acids Res, 2009 Jun. PMID 19339515, Free PMC Article
  3. Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents. Izumchenko E, et al. DNA Repair (Amst), 2012 Dec 1. PMID 23062884, Free PMC Article
  4. MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective. Zhao X, et al. PLoS Genet, 2018 Oct. PMID 30312299, Free PMC Article
  5. Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Wei K, et al. Genes Dev, 2003 Mar 1. PMID 12629043, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dynamic regulation of EXO1 promotes the progression from liver fibrosis to HCC through TGF-beta1/Smad signaling feedback loop.
    Title: Dynamic regulation of EXO1 promotes the progression from liver fibrosis to HCC through TGF-β1/Smad signaling feedback loop.
  2. Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice.
    Title: Role of EXO1 nuclease activity in genome maintenance, the immune response and tumor suppression in Exo1D173A mice.
  3. Calcium-stimulated AMPK-dependent phosphorylation of Exo1 protects stressed replication forks from aberrant resection.
    Title: Ca(2+)-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection.
  4. It has been found that deletion of 53BP1 can relieve several of the repair deficiencies observed in B-cells lacking BLM and Exo1, just as it does in cells lacking BRCA1.
    Title: DNA repair and cell cycle checkpoint defects in a mouse model of 'BRCAness' are partially rescued by 53BP1 deletion.
  5. mice homozygous for a point mutation (D173A) in Exo1 that eliminates its nuclease activity but retains its native conformation, shows a level of trinucleotide expansion that is intermediate between Exo1+/+ and Exo1-/- animals.
    Title: MutLγ promotes repeat expansion in a Fragile X mouse model while EXO1 is protective.
  6. like canonical DNA mismatch-repair proteins, EXO1 can restrain aberrant homologous recombination events between diverged sequence elements in the genome.
    Title: EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells.
  7. The results establish a key role for EXO1 in modulating the severity of hypomorphic MRE11 complex mutations.
    Title: EXO1 is critical for embryogenesis and the DNA damage response in mice with a hypomorphic Nbs1 allele.
  8. Exo1-mediated HR is dispensable for stem cell function in quiescent HSC, whereas it is essential to HSC response to DNA damage processing after cell cycle entry, and its loss is not compensated by intact NHEJ
    Title: Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells.
  9. In contrast to Exo1(null/null) mice, Exo1(E109K/E109K) knockin mice retain mismatch repair activity and display normal class switch recombination and meiosis.
    Title: Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes.
  10. RNAi-mediated EXO1 knockdown in mouse fibroblasts directly results in an alkylation-tolerant phenotype.
    Title: Exonuclease 1 (Exo1) is required for activating response to S(N)1 DNA methylating agents.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables 5'-3' exonuclease activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables double-stranded DNA 5'-3' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables double-stranded DNA 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables flap endonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables flap endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity ISO
Inferred from Sequence Orthology
more info
  
enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in DNA strand resection involved in replication fork processing IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA strand resection involved in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within humoral immune response mediated by circulating immunoglobulin IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within isotype switching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mismatch repair ISO
Inferred from Sequence Orthology
more info
  
involved_in mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within nucleobase-containing compound metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within somatic hypermutation of immunoglobulin genes IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear body IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
exonuclease 1
Names
exonuclease I
mExo1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012012.4 → NP_036142.2  exonuclease 1

    See identical proteins and their annotated locations for NP_036142.2

    Status: VALIDATED

    Source sequence(s)
    AC122854
    Consensus CDS
    CCDS15551.1
    UniProtKB/Swiss-Prot
    Q3TLM4, Q923A5, Q9QZ11
    Related
    ENSMUSP00000039376.7, ENSMUST00000039725.12
    Conserved Domains (3) summary
    cd09908
    Location:213 → 289
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1 → 201
    PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    pfam05110
    Location:555 → 765
    AF-4; AF-4 proto-oncoprotein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    175708334..175738962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496862.5 → XP_006496925.1  exonuclease 1 isoform X1

    See identical proteins and their annotated locations for XP_006496925.1

    UniProtKB/Swiss-Prot
    Q3TLM4, Q923A5, Q9QZ11
    Conserved Domains (3) summary
    cd09908
    Location:213 → 289
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1 → 201
    PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    pfam05110
    Location:555 → 765
    AF-4; AF-4 proto-oncoprotein

  2. XM_030254499.2 → XP_030110359.1  exonuclease 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3TLM4, Q923A5, Q9QZ11
    Conserved Domains (3) summary
    cd09908
    Location:213 → 289
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1 → 201
    PIN_EXO1; FEN-like PIN domains of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs
    pfam05110
    Location:555 → 765
    AF-4; AF-4 proto-oncoprotein

RNA

  1. XR_004942539.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QZ11.2 GenPept UniProtKB/Swiss-Prot:Q9QZ11

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