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Caskin1 CASK interacting protein 1 [ Mus musculus (house mouse) ]

Gene ID: 268932, updated on 2-Nov-2024

Summary

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Official Symbol
Caskin1provided by MGI
Official Full Name
CASK interacting protein 1provided by MGI
Primary source
MGI:MGI:2442952
See related
Ensembl:ENSMUSG00000033597 AllianceGenome:MGI:2442952
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA1306; C130061I24; 3300002N10Rik; C630036E02Rik
Summary
Predicted to enable identical protein binding activity and protein domain specific binding activity. Involved in regulation of postsynaptic density assembly. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including adrenal gland; bladder; eye; intestine; and nervous system. Orthologous to human CASKIN1 (CASK interacting protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 20.2), CNS E18 (RPKM 20.0) and 10 other tissues See more
Orthologs
human all
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Genomic context

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See Caskin1 in Genome Data Viewer
Location:
17 A3.3; 17 12.4 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24706871..24727883)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24487897..24508909)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene phosphoglycolate phosphatase Neighboring gene STARR-positive B cell enhancer ABC_E5578 Neighboring gene BRICHOS domain containing 5 Neighboring gene MTOR associated protein, LST8 homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_42087 Neighboring gene TNF receptor-associated factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E33 Neighboring gene RAB26, member RAS oncogene family, opposite strand Neighboring gene small nucleolar RNA, C/D box 60 Neighboring gene RAB26, member RAS oncogene family

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery. Katano T, et al. Mol Brain, 2018 Oct 25. PMID 30359304, Free PMC Article
  2. Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins. Bencsik N, et al. Sci Rep, 2019 Nov 14. PMID 31727973, Free PMC Article
  3. miR-218 Promotes Dopaminergic Differentiation and Controls Neuron Excitability and Neurotransmitter Release through the Regulation of a Synaptic-Related Genes Network. Pulcrano S, et al. J Neurosci, 2023 Nov 29. PMID 37816598, Free PMC Article
  4. Neurotransmitter release regulated by a MALS-liprin-alpha presynaptic complex. Olsen O, et al. J Cell Biol, 2005 Sep 26. PMID 16186258, Free PMC Article
  5. Proteomics analysis identifies phosphorylation-dependent alpha-synuclein protein interactions. McFarland MA, et al. Mol Cell Proteomics, 2008 Nov. PMID 18614564, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
    Title: Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
  2. Caskin1 contributes to a wide spectrum of behavioral phenotypes.
    Title: Distribution of Caskin1 protein and phenotypic characterization of its knockout mice using a comprehensive behavioral test battery.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in regulation of postsynaptic density assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic density assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
caskin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360469.1 → NP_001347398.1  caskin-1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132367, AC154237
    Consensus CDS
    CCDS89007.1
    UniProtKB/TrEMBL
    B7ZNJ3
    Related
    ENSMUSP00000157196.2, ENSMUST00000234717.2
    Conserved Domains (9) summary
    cd09498
    Location:478 → 540
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12062
    Location:284 → 345
    SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
    cd00204
    Location:43 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:114 → 145
    ANK; ANK repeat [structural motif]
    pfam13637
    Location:7 → 69
    Ank_4; Ankyrin repeats (many copies)
    pfam16600
    Location:373 → 421
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1298 → 1360
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:807 → 878
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    cl25751
    Location:616 → 758
    DUF4045; Domain of unknown function (DUF4045)

  2. NM_027937.2 → NP_082213.2  caskin-1 isoform 1

    See identical proteins and their annotated locations for NP_082213.2

    Status: VALIDATED

    Source sequence(s)
    BC059916, BC060720, CJ127019
    Consensus CDS
    CCDS50013.1
    UniProtKB/Swiss-Prot
    Q6P9K8, Q6ZPU2, Q8BWU2, Q8BX99, Q9CXH0
    UniProtKB/TrEMBL
    B7ZNJ3
    Related
    ENSMUSP00000024958.8, ENSMUST00000024958.9
    Conserved Domains (12) summary
    cd09497
    Location:475 → 540
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:541 → 611
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    smart00454
    Location:474 → 536
    SAM; Sterile alpha motif
    cd12062
    Location:284 → 345
    SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
    cd00204
    Location:43 → 168
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:119 → 218
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:7 → 69
    Ank_4; Ankyrin repeats (many copies)
    pfam13857
    Location:208 → 261
    Ank_5; Ankyrin repeats (many copies)
    pfam16600
    Location:373 → 421
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1369 → 1431
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:878 → 949
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    sd00045
    Location:114 → 145
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24706871..24727883
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524313.3 → XP_006524376.1  caskin-1 isoform X1

    UniProtKB/TrEMBL
    B7ZNJ3
    Conserved Domains (11) summary
    PTZ00449
    Location:694 → 836
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09497
    Location:482 → 547
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:548 → 618
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12062
    Location:291 → 352
    SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
    COG0666
    Location:55 → 258
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:121 → 152
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:126 → 225
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:380 → 428
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1376 → 1438
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:885 → 956
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    cl39094
    Location:232 → 289
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_030249826.1 → XP_030105686.1  caskin-1 isoform X4

    UniProtKB/TrEMBL
    B7ZNJ3
    Conserved Domains (10) summary
    PTZ00449
    Location:623 → 765
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09498
    Location:485 → 547
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12062
    Location:291 → 352
    SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
    COG0666
    Location:55 → 258
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:121 → 152
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:126 → 225
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:380 → 428
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1305 → 1367
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:814 → 885
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    cl39094
    Location:232 → 289
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_036160626.1 → XP_036016519.1  caskin-1 isoform X2

    UniProtKB/TrEMBL
    B7ZNJ3
    Conserved Domains (11) summary
    PTZ00449
    Location:667 → 809
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09497
    Location:455 → 520
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:521 → 591
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12062
    Location:264 → 325
    SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
    COG0666
    Location:28 → 231
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    sd00045
    Location:94 → 125
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:99 → 198
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:353 → 401
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1349 → 1411
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:858 → 929
    Caskin-Pro-rich; Proline rich region of Caskin proteins
    cl39094
    Location:205 → 265
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_036160627.1 → XP_036016520.1  caskin-1 isoform X3

    UniProtKB/TrEMBL
    B7ZNJ3
    Conserved Domains (10) summary
    PTZ00449
    Location:660 → 802
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09497
    Location:448 → 513
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:514 → 584
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    cd12062
    Location:257 → 318
    SH3_Caskin1; Src Homology 3 domain of CASK interacting protein 1
    PHA03095
    Location:14 → 231
    PHA03095; ankyrin-like protein; Provisional
    sd00045
    Location:87 → 118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:92 → 191
    Ank_2; Ankyrin repeats (3 copies)
    pfam16600
    Location:346 → 394
    Caskin1-CID; Caskin1 CASK-interaction domain
    pfam16632
    Location:1342 → 1404
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:851 → 922
    Caskin-Pro-rich; Proline rich region of Caskin proteins

  5. XM_006524316.5 → XP_006524379.1  caskin-1 isoform X5

    Conserved Domains (5) summary
    PTZ00449
    Location:252 → 394
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd09497
    Location:42 → 105
    SAM_caskin1,2_repeat1; SAM domain of caskin protein repeat 1
    cd09498
    Location:106 → 176
    SAM_caskin1,2_repeat2; SAM domain of caskin protein repeat 2
    pfam16632
    Location:934 → 996
    Caskin-tail; C-terminal region of Caskin
    pfam16907
    Location:443 → 514
    Caskin-Pro-rich; Proline rich region of Caskin proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P9K8.2 GenPept UniProtKB/Swiss-Prot:Q6P9K8

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