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Rbfox1 RNA binding protein, fox-1 homolog (C. elegans) 1 [ Mus musculus (house mouse) ]

Gene ID: 268859, updated on 28-Oct-2024

Summary

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Official Symbol
Rbfox1provided by MGI
Official Full Name
RNA binding protein, fox-1 homolog (C. elegans) 1provided by MGI
Primary source
MGI:MGI:1926224
See related
Ensembl:ENSMUSG00000008658 AllianceGenome:MGI:1926224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A2bp; A2bp1; fox-1; Hrnbp1
Summary
Enables mRNA 3'-UTR binding activity. Acts upstream of or within neuromuscular process controlling balance; regulation of alternative mRNA splicing, via spliceosome; and regulation of skeletal muscle cell differentiation. Located in cytoplasm and nucleus. Is expressed in central nervous system; cranial nerve; heart; peripheral nervous system ganglion; and retina. Orthologous to human RBFOX1 (RNA binding fox-1 homolog 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in cerebellum adult (RPKM 4.4), cortex adult (RPKM 3.4) and 5 other tissues See more
Orthologs
human all
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Genomic context

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See Rbfox1 in Genome Data Viewer
Location:
16 A1; 16 3.34 cM
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (5702566..7230344)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (5884793..7412480)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41414 Neighboring gene STARR-seq mESC enhancer starr_39960 Neighboring gene STARR-seq mESC enhancer starr_39962 Neighboring gene predicted gene, 41416 Neighboring gene STARR-positive B cell enhancer mm9_chr16:5709155-5709456 Neighboring gene STARR-seq mESC enhancer starr_39963 Neighboring gene RIKEN cDNA 1700123O21 gene Neighboring gene STARR-seq mESC enhancer starr_39966 Neighboring gene predicted gene, 52234 Neighboring gene predicted gene, 36902 Neighboring gene STARR-seq mESC enhancer starr_39967 Neighboring gene STARR-seq mESC enhancer starr_39968 Neighboring gene predicted gene, 53933 Neighboring gene predicted gene, 52235 Neighboring gene STARR-seq mESC enhancer starr_39969 Neighboring gene predicted gene, 36824 Neighboring gene STARR-seq mESC enhancer starr_39971 Neighboring gene STARR-seq mESC enhancer starr_39973 Neighboring gene STARR-seq mESC enhancer starr_39974 Neighboring gene STARR-seq mESC enhancer starr_39975 Neighboring gene STARR-seq mESC enhancer starr_39977 Neighboring gene STARR-seq mESC enhancer starr_39978 Neighboring gene STARR-seq mESC enhancer starr_39979 Neighboring gene STARR-seq mESC enhancer starr_39984 Neighboring gene STARR-seq mESC enhancer starr_39985 Neighboring gene STARR-seq mESC enhancer starr_39987 Neighboring gene STARR-seq mESC enhancer starr_39988 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:7419874-7419983 Neighboring gene STARR-seq mESC enhancer starr_39989 Neighboring gene STARR-seq mESC enhancer starr_39990 Neighboring gene STARR-seq mESC enhancer starr_39991 Neighboring gene STARR-seq mESC enhancer starr_39992 Neighboring gene STARR-seq mESC enhancer starr_39993 Neighboring gene STARR-seq mESC enhancer starr_39994 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:7767895-7768078 Neighboring gene STARR-seq mESC enhancer starr_39996 Neighboring gene STARR-seq mESC enhancer starr_39998 Neighboring gene STARR-seq mESC enhancer starr_39999 Neighboring gene predicted gene, 29854 Neighboring gene STARR-seq mESC enhancer starr_40001 Neighboring gene STARR-seq mESC enhancer starr_40002 Neighboring gene predicted gene, 26159

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Visual Function and Survival of Injured Retinal Ganglion Cells in Aged Rbfox1 Knockout Animals. Gu L, et al. Cells, 2022 Oct 27. PMID 36359797, Free PMC Article
  2. Essential role of the nuclear isoform of RBFOX1, a candidate gene for autism spectrum disorders, in the brain development. Hamada N, et al. Sci Rep, 2016 Aug 2. PMID 27481563, Free PMC Article
  3. Developmental expression mapping of a gene implicated in multiple neurodevelopmental disorders, A2bp1 (Fox1). Hammock EA, et al. Dev Neurosci, 2011. PMID 21346316, Free PMC Article
  4. Rbfox1 Is Expressed in the Mouse Brain in the Form of Multiple Transcript Variants and Contains Functional E Boxes in Its Alternative Promoters. Casanovas S, et al. Front Mol Neurosci, 2020. PMID 32431595, Free PMC Article
  5. An inducible change in Fox-1/A2BP1 splicing modulates the alternative splicing of downstream neuronal target exons. Lee JA, et al. Genes Dev, 2009 Oct 1. PMID 19762510, Free PMC Article

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Visual Function and Survival of Injured Retinal Ganglion Cells in Aged Rbfox1 Knockout Animals.
    Title: Visual Function and Survival of Injured Retinal Ganglion Cells in Aged Rbfox1 Knockout Animals.
  2. Transcriptional regulation of the thymus master regulator Foxn1.
    Title: Transcriptional regulation of the thymus master regulator Foxn1.
  3. Rbfox1 expression in amacrine cells is restricted to GABAergic and VGlut3 glycinergic cells.
    Title: Rbfox1 expression in amacrine cells is restricted to GABAergic and VGlut3 glycinergic cells.
  4. Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNAbinding protein RBFOX1 in this disease.
    Title: Identification of inflammatory response and alternative splicing in acute kidney injury and experimental verification of the involvement of RNA‑binding protein RBFOX1 in this disease.
  5. Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models.
    Title: Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models.
  6. The authors found that upregulation of Rbfox1, an RNA binding protein associated with intellectual disability, epilepsy and autism, increases selectively hippocampal TrkB.T1 isoform expression. Physiologically, increased Rbfox1 impairs BDNF-dependent LTP which can be rescued by genetically restoring TrkB.T1 levels.
    Title: Rbfox1 up-regulation impairs BDNF-dependent hippocampal LTP by dysregulating TrkB isoform expression levels.
  7. Rbfox deletion did not cause a reduction in global protein synthesis, but it led to altered splicing of hundreds of gene transcripts, including capn3, which produced an active form of calpain3 protease.
    Title: Rbfox-Splicing Factors Maintain Skeletal Muscle Mass by Regulating Calpain3 and Proteostasis.
  8. The data imply Rbfox1 may be involved in the development of cardiomyopathies via regulating the alternative splicing of CaV1.2 exon 33.
    Title: Characterization of Ca(V)1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and Ca(V)1.2 exon 33 expressions in human heart failure.
  9. Rbfox1 is a regulator in the development of cortical interneuron-subtype-specific efferent connectivity.
    Title: Rbfox1 Mediates Cell-type-Specific Splicing in Cortical Interneurons.
  10. The regulation of interneuron-specific Vamp1 by Rbfox1 contributes to performance of specialized functions in defined neuronal subtypes.
    Title: Rbfox1 Regulates Synaptic Transmission through the Inhibitory Neuron-Specific vSNARE Vamp1.
Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA binding protein fox-1 homolog 1
Names
ataxin 2 binding protein 1
fox-1 homolog A
hexaribonucleotide binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359723.2 → NP_001346652.1  RNA binding protein fox-1 homolog 1 isoform gamma

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (gamma), compared to isoform 1.
    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654
    Consensus CDS
    CCDS37245.1
    UniProtKB/Swiss-Prot
    Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
    UniProtKB/TrEMBL
    A0A2R8VK79
    Related
    ENSMUSP00000155069.3, ENSMUST00000230658.3
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:252 → 341
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  2. NM_001359724.2 → NP_001346653.1  RNA binding protein fox-1 homolog 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (1).
    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:252 → 338
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  3. NM_001359725.2 → NP_001346654.1  RNA binding protein fox-1 homolog 1 isoform gamma

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in both UTR's and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (gamma), compared to isoform 1.
    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654, AC164097
    Consensus CDS
    CCDS37245.1
    UniProtKB/Swiss-Prot
    Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
    UniProtKB/TrEMBL
    A0A2R8VK79
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:252 → 341
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  4. NM_001359726.2 → NP_001346655.1  RNA binding protein fox-1 homolog 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654
    Conserved Domains (3) summary
    cd12407
    Location:140 → 215
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:249 → 337
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl27169
    Location:48 → 145
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

  5. NM_001359728.2 → NP_001346657.1  RNA binding protein fox-1 homolog 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654
    UniProtKB/TrEMBL
    A0A2R8VK79
    Conserved Domains (3) summary
    cd12407
    Location:140 → 215
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:276 → 365
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl27169
    Location:48 → 145
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

  6. NM_001359729.2 → NP_001346658.1  RNA binding protein fox-1 homolog 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in both UTR's and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654
    UniProtKB/TrEMBL
    A0A2R8VK79, A0AAQ4VMR5
    Related
    ENSMUSP00000159958.1, ENSMUST00000249862.1
    Conserved Domains (3) summary
    cd12407
    Location:140 → 215
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:276 → 364
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl27169
    Location:48 → 145
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

  7. NM_001359730.2 → NP_001346659.1  RNA binding protein fox-1 homolog 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) has multiple coding region differences, compared to variant 4. This results in a shorter isoform (5), compared to isoform 1.
    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654
    UniProtKB/TrEMBL
    A0A2R8VK79
    Conserved Domains (3) summary
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:252 → 341
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cl27169
    Location:4 → 121
    ZipA; ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic ...

  8. NM_001417334.1 → NP_001404263.1  RNA binding protein fox-1 homolog 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
    UniProtKB/TrEMBL
    A0AAQ4VMS4
    Related
    ENSMUSP00000159975.1, ENSMUST00000249878.1

  9. NM_001417335.1 → NP_001404264.1  RNA binding protein fox-1 homolog 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  10. NM_001417336.1 → NP_001404265.1  RNA binding protein fox-1 homolog 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654

  11. NM_001417337.1 → NP_001404266.1  RNA binding protein fox-1 homolog 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  12. NM_001417338.1 → NP_001404267.1  RNA binding protein fox-1 homolog 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC161378, AC163654

  13. NM_001417339.1 → NP_001404268.1  RNA binding protein fox-1 homolog 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC161378, AC163654
    UniProtKB/TrEMBL
    A0AAQ4VMX8
    Related
    ENSMUSP00000160018.1, ENSMUST00000249920.1

  14. NM_001417340.1 → NP_001404269.1  RNA binding protein fox-1 homolog 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654

  15. NM_001417341.1 → NP_001404270.1  RNA binding protein fox-1 homolog 1 isoform gamma

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
    UniProtKB/Swiss-Prot
    Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
    Related
    ENSMUSP00000049970.9, ENSMUST00000056416.9

  16. NM_001417342.1 → NP_001404271.1  RNA binding protein fox-1 homolog 1 isoform gamma

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
    UniProtKB/Swiss-Prot
    Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
    Related
    ENSMUSP00000111507.4, ENSMUST00000115841.10

  17. NM_001417343.1 → NP_001404272.1  RNA binding protein fox-1 homolog 1 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654

  18. NM_001417344.1 → NP_001404273.1  RNA binding protein fox-1 homolog 1 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654

  19. NM_001417345.1 → NP_001404274.1  RNA binding protein fox-1 homolog 1 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC154705, AC161378, AC163654

  20. NM_001417376.1 → NP_001404305.1  RNA binding protein fox-1 homolog 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  21. NM_001417377.1 → NP_001404306.1  RNA binding protein fox-1 homolog 1 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

  22. NM_001417379.1 → NP_001404308.1  RNA binding protein fox-1 homolog 1 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  23. NM_001417380.1 → NP_001404309.1  RNA binding protein fox-1 homolog 1 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654

  24. NM_001417381.1 → NP_001404310.1  RNA binding protein fox-1 homolog 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
    Related
    ENSMUSP00000155799.3, ENSMUST00000231088.3

  25. NM_001417382.1 → NP_001404311.1  RNA binding protein fox-1 homolog 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654, AC164097

  26. NM_001417383.1 → NP_001404312.1  RNA binding protein fox-1 homolog 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  27. NM_001417384.1 → NP_001404313.1  RNA binding protein fox-1 homolog 1 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

  28. NM_001417385.1 → NP_001404314.1  RNA binding protein fox-1 homolog 1 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC161378, AC163654

  29. NM_001417386.1 → NP_001404315.1  RNA binding protein fox-1 homolog 1 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC161378, AC163654
    Related
    ENSMUSP00000155321.2, ENSMUST00000231194.2

  30. NM_001417387.1 → NP_001404316.1  RNA binding protein fox-1 homolog 1 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC154705, AC161378, AC163654

  31. NM_001417388.1 → NP_001404317.1  RNA binding protein fox-1 homolog 1 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  32. NM_001417389.1 → NP_001404318.1  RNA binding protein fox-1 homolog 1 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654
    Related
    ENSMUSP00000159957.1, ENSMUST00000249861.1

  33. NM_001417390.1 → NP_001404319.1  RNA binding protein fox-1 homolog 1 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

  34. NM_001417391.1 → NP_001404320.1  RNA binding protein fox-1 homolog 1 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654

  35. NM_001417392.1 → NP_001404321.1  RNA binding protein fox-1 homolog 1 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC154705, AC161378, AC163654

  36. NM_001417393.1 → NP_001404322.1  RNA binding protein fox-1 homolog 1 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  37. NM_001417394.1 → NP_001404323.1  RNA binding protein fox-1 homolog 1 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  38. NM_001417395.1 → NP_001404324.1  RNA binding protein fox-1 homolog 1 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  39. NM_001417396.1 → NP_001404325.1  RNA binding protein fox-1 homolog 1 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

  40. NM_001417398.1 → NP_001404327.1  RNA binding protein fox-1 homolog 1 isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654

  41. NM_001417399.1 → NP_001404328.1  RNA binding protein fox-1 homolog 1 isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  42. NM_001417400.1 → NP_001404329.1  RNA binding protein fox-1 homolog 1 isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

  43. NM_001417403.1 → NP_001404332.1  RNA binding protein fox-1 homolog 1 isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC161378, AC163654

  44. NM_001417404.1 → NP_001404333.1  RNA binding protein fox-1 homolog 1 isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC161378, AC163654

  45. NM_001417405.1 → NP_001404334.1  RNA binding protein fox-1 homolog 1 isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  46. NM_001417406.1 → NP_001404335.1  RNA binding protein fox-1 homolog 1 isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC124551, AC125179, AC154705, AC161378, AC163654

  47. NM_001417407.1 → NP_001404336.1  RNA binding protein fox-1 homolog 1 isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

  48. NM_001417408.1 → NP_001404337.1  RNA binding protein fox-1 homolog 1 isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654

  49. NM_001417409.1 → NP_001404338.1  RNA binding protein fox-1 homolog 1 isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC124225, AC161378, AC163654

  50. NM_021477.6 → NP_067452.2  RNA binding protein fox-1 homolog 1 isoform gamma

    See identical proteins and their annotated locations for NP_067452.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in both UTR's and has multiple coding region differences, compared to variant 4. This results in a shorter isoform (gamma), compared to isoform 1.
    Source sequence(s)
    AC123862, AC123924, AC124225, AC125179, AC154705, AC161378, AC163654, AC164097
    Consensus CDS
    CCDS37245.1
    UniProtKB/Swiss-Prot
    Q3UYA8, Q537C9, Q537D0, Q537D1, Q537D2, Q6PD12, Q8R4Z7, Q9JJ43, Q9JJB5
    UniProtKB/TrEMBL
    A0A2R8VK79
    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:252 → 341
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  51. NM_183188.3 → NP_899011.2  RNA binding protein fox-1 homolog 1 isoform alpha

    See identical proteins and their annotated locations for NP_899011.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in both UTR's and has multiple coding region differences, compared to 4 . This results in a shorter isoform (alpha), compared to isoform 1.
    Source sequence(s)
    AC122000, AC124225, AC161378, AC163654
    Consensus CDS
    CCDS27936.1
    UniProtKB/TrEMBL
    A0A2R8VK79
    Related
    ENSMUSP00000155364.2, ENSMUST00000229741.2
    Conserved Domains (3) summary
    COG0724
    Location:82 → 219
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12407
    Location:136 → 211
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:272 → 362
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    5702566..7230344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522179.4 → XP_006522242.1  RNA binding protein fox-1 homolog 1 isoform X21

    See identical proteins and their annotated locations for XP_006522242.1

    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:252 → 341
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  2. XM_036159945.1 → XP_036015838.1  RNA binding protein fox-1 homolog 1 isoform X31

    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:225 → 311
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  3. XM_036159943.1 → XP_036015836.1  RNA binding protein fox-1 homolog 1 isoform X30

    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:225 → 312
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  4. XM_036159933.1 → XP_036015826.1  RNA binding protein fox-1 homolog 1 isoform X15

    Conserved Domains (3) summary
    PRK03427
    Location:40 → 157
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:288 → 374
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:152 → 227
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  5. XM_036159939.1 → XP_036015832.1  RNA binding protein fox-1 homolog 1 isoform X25

    UniProtKB/TrEMBL
    A0A2R8VK79
    Conserved Domains (3) summary
    PRK03427
    Location:40 → 157
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:288 → 377
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:152 → 227
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  6. XM_006522173.5 → XP_006522236.1  RNA binding protein fox-1 homolog 1 isoform X14

    Conserved Domains (3) summary
    PRK03427
    Location:40 → 157
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:152 → 227
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:288 → 377
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  7. XM_036159936.1 → XP_036015829.1  RNA binding protein fox-1 homolog 1 isoform X20

    Conserved Domains (3) summary
    PRK03427
    Location:40 → 157
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:261 → 347
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:152 → 227
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  8. XM_036159941.1 → XP_036015834.1  RNA binding protein fox-1 homolog 1 isoform X27

    UniProtKB/TrEMBL
    A0A2R8VI79, A0A2R8VK79
    Conserved Domains (3) summary
    PRK03427
    Location:40 → 157
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:261 → 350
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:152 → 227
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  9. XM_036159935.1 → XP_036015828.1  RNA binding protein fox-1 homolog 1 isoform X19

    Conserved Domains (3) summary
    PRK03427
    Location:40 → 157
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:261 → 348
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:152 → 227
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  10. XM_011245907.4 → XP_011244209.2  RNA binding protein fox-1 homolog 1 isoform X2

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:379 → 467
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  11. XM_017316989.3 → XP_017172478.2  RNA binding protein fox-1 homolog 1 isoform X8

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:379 → 468
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  12. XM_006522155.5 → XP_006522218.3  RNA binding protein fox-1 homolog 1 isoform X1

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:379 → 468
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  13. XM_011245915.4 → XP_011244217.2  RNA binding protein fox-1 homolog 1 isoform X9

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:379 → 468
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  14. XM_011245914.4 → XP_011244216.2  RNA binding protein fox-1 homolog 1 isoform X7

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:379 → 469
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  15. XM_011245910.4 → XP_011244212.2  RNA binding protein fox-1 homolog 1 isoform X3

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:379 → 469
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  16. XM_017316988.3 → XP_017172477.2  RNA binding protein fox-1 homolog 1 isoform X6

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:352 → 440
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  17. XM_030249123.2 → XP_030104983.1  RNA binding protein fox-1 homolog 1 isoform X12

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:352 → 441
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  18. XM_011245912.4 → XP_011244214.2  RNA binding protein fox-1 homolog 1 isoform X5

    Conserved Domains (3) summary
    PRK03427
    Location:131 → 248
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:243 → 318
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:352 → 441
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  19. XM_006522178.4 → XP_006522241.1  RNA binding protein fox-1 homolog 1 isoform X21

    See identical proteins and their annotated locations for XP_006522241.1

    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:252 → 341
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  20. XM_036159946.1 → XP_036015839.1  RNA binding protein fox-1 homolog 1 isoform X31

    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:225 → 311
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  21. XM_036159944.1 → XP_036015837.1  RNA binding protein fox-1 homolog 1 isoform X30

    Conserved Domains (3) summary
    PRK03427
    Location:4 → 121
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:225 → 312
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:116 → 191
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

  22. XM_030249125.1 → XP_030104985.1  RNA binding protein fox-1 homolog 1 isoform X17

    Conserved Domains (3) summary
    PRK03427
    Location:48 → 145
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:140 → 215
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:276 → 364
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  23. XM_006522175.5 → XP_006522238.1  RNA binding protein fox-1 homolog 1 isoform X16

    Conserved Domains (3) summary
    PRK03427
    Location:48 → 145
    PRK03427; cell division protein ZipA; Provisional
    cd12407
    Location:140 → 215
    RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
    pfam12414
    Location:276 → 365
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal

  24. XM_036159938.1 → XP_036015831.1  RNA binding protein fox-1 homolog 1 isoform X24

    Conserved Domains (3) summary
    PRK03427
    Location:48 → 145
    PRK03427; cell division protein ZipA; Provisional
    pfam12414
    Location:249 → 336
    Fox-1_C; Calcitonin gene-related peptide regulator C terminal
    cd12407
    Location:140 → 215
    RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJ43.3 GenPept UniProtKB/Swiss-Prot:Q9JJ43

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