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Carmil3 capping protein regulator and myosin 1 linker 3 [ Mus musculus (house mouse) ]

Gene ID: 268747, updated on 2-Nov-2024

Summary

Official Symbol
Carmil3provided by MGI
Official Full Name
capping protein regulator and myosin 1 linker 3provided by MGI
Primary source
MGI:MGI:2448573
See related
Ensembl:ENSMUSG00000022211 AllianceGenome:MGI:2448573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrrc16b; mFLJ00240
Summary
Involved in regulation of postsynapse assembly. Is active in glutamatergic synapse and postsynapse. Is expressed in central nervous system; dorsal root ganglion; extraembryonic component; and olfactory epithelium. Orthologous to human CARMIL3 (capping protein regulator and myosin 1 linker 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in CNS E18 (RPKM 51.3), CNS E14 (RPKM 47.6) and 9 other tissues See more
Orthologs
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Genomic context

See Carmil3 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55728108..55745729)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55490651..55508272)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41158 Neighboring gene dehydrogenase/reductase 4 Neighboring gene copine VI Neighboring gene neural retina leucine zipper gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of Arp2/3 complex-mediated actin nucleation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in lamellipodium IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
capping protein, Arp2/3 and myosin-I linker protein 3
Names
capping protein regulator and myosin 1 linker protein 3
leucine-rich repeat-containing protein 16B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024645.2NP_001019816.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001019816.1

    Status: VALIDATED

    Source sequence(s)
    AK148355, AK158466, BC060252, BC082805
    Consensus CDS
    CCDS36930.1
    UniProtKB/Swiss-Prot
    Q3UFQ8, Q6KAP3
    Related
    ENSMUSP00000075587.6, ENSMUST00000076236.7
    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781061
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  2. NM_001374103.1NP_001361032.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. NM_001374104.1NP_001361033.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781061
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. NM_001374105.1NP_001361034.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781061
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

RNA

  1. NR_155103.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Related
    ENSMUST00000228877.2
  2. NR_155104.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AK148355, AK158466, BC082805
    Related
    ENSMUST00000227312.2
  3. NR_164326.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC159002
    Related
    ENSMUST00000226757.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55728108..55745729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247836.2XP_030103696.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17

    Conserved Domains (1) summary
    pfam16000
    Location:198483
    CARMIL_C; CARMIL C-terminus
  2. XM_030247833.2XP_030103693.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X13

    Conserved Domains (4) summary
    sd00033
    Location:6997
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:3967
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:572856
    CARMIL_C; CARMIL C-terminus
    cl39015
    Location:101394
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  3. XM_006519058.4XP_006519121.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16

    Conserved Domains (3) summary
    sd00033
    Location:1445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:399683
    CARMIL_C; CARMIL C-terminus
    cl39015
    Location:37249
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  4. XM_006519056.4XP_006519119.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12

    See identical proteins and their annotated locations for XP_006519119.1

    Conserved Domains (4) summary
    sd00033
    Location:128156
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:98126
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:631915
    CARMIL_C; CARMIL C-terminus
    cl39015
    Location:160453
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  5. XM_006519047.5XP_006519110.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X1

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  6. XM_006519049.5XP_006519112.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X3

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  7. XM_006519050.5XP_006519113.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X4

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  8. XM_017316027.3XP_017171516.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X6

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  9. XM_036158607.1XP_036014500.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X7

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781063
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  10. XM_006519053.5XP_006519116.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X8

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  11. XM_030247832.2XP_030103692.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X9

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  12. XM_006519048.5XP_006519111.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X2

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781061
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  13. XM_030247830.2XP_030103690.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X5

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781061
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  14. XM_036158608.1XP_036014501.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X10

    Conserved Domains (5) summary
    sd00033
    Location:275303
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:245273
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:7781062
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:307600
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  15. XM_030247835.2XP_030103695.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X16

    Conserved Domains (3) summary
    sd00033
    Location:1445
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:399683
    CARMIL_C; CARMIL C-terminus
    cl39015
    Location:37249
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  16. XM_036158610.1XP_036014503.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X17

    Conserved Domains (1) summary
    pfam16000
    Location:198483
    CARMIL_C; CARMIL C-terminus
  17. XM_030247834.2XP_030103694.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X14

    Conserved Domains (3) summary
    sd00033
    Location:5381
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:495779
    CARMIL_C; CARMIL C-terminus
    cl39015
    Location:24272
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  18. XM_036158609.1XP_036014502.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X15

    Conserved Domains (3) summary
    sd00033
    Location:5381
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:495779
    CARMIL_C; CARMIL C-terminus
    cl39015
    Location:24272
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  19. XM_006519054.5XP_006519117.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X11

    Conserved Domains (4) summary
    sd00033
    Location:261289
    LRR_RI; leucine-rich repeat [structural motif]
    pfam16000
    Location:7641048
    CARMIL_C; CARMIL C-terminus
    pfam17888
    Location:30118
    Carm_PH; Carmil pleckstrin homology domain
    cl39015
    Location:293586
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  20. XM_006519055.5XP_006519118.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X12

    See identical proteins and their annotated locations for XP_006519118.1

    Conserved Domains (4) summary
    sd00033
    Location:128156
    LRR_RI; leucine-rich repeat [structural motif]
    sd00034
    Location:98126
    LRR_AMN1; leucine-rich repeat [structural motif]
    pfam16000
    Location:631915
    CARMIL_C; CARMIL C-terminus
    cl39015
    Location:160453
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
  21. XM_006519060.4XP_006519123.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X18

    Related
    ENSMUST00000226388.2
    Conserved Domains (1) summary
    pfam16000
    Location:110394
    CARMIL_C; CARMIL C-terminus
  22. XM_006519061.4XP_006519124.1  capping protein, Arp2/3 and myosin-I linker protein 3 isoform X19

    Conserved Domains (1) summary
    pfam16000
    Location:91375
    CARMIL_C; CARMIL C-terminus

RNA

  1. XR_004938405.1 RNA Sequence

  2. XR_383182.5 RNA Sequence

  3. XR_004938403.1 RNA Sequence

  4. XR_004938406.1 RNA Sequence

  5. XR_004938404.1 RNA Sequence

  6. XR_383183.5 RNA Sequence