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Frmpd2 FERM and PDZ domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 268729, updated on 28-Oct-2024

Summary

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Official Symbol
Frmpd2provided by MGI
Official Full Name
FERM and PDZ domain containing 2provided by MGI
Primary source
MGI:MGI:2685472
See related
Ensembl:ENSMUSG00000108841 AllianceGenome:MGI:2685472
Gene type
protein coding
RefSeq status
MODEL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm626; Gm1582
Summary
Predicted to enable 1-phosphatidylinositol binding activity. Predicted to be involved in bicellular tight junction assembly. Predicted to be located in basolateral plasma membrane and bicellular tight junction. Is expressed in central nervous system; ganglia; and retina. Orthologous to human FRMPD2 (FERM and PDZ domain containing 2). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Frmpd2 in Genome Data Viewer
Location:
14 B; 14 20.46 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33193475..33297226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33483501..33575269)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 22 Neighboring gene predicted gene, 41130 Neighboring gene STARR-seq mESC enhancer starr_36351 Neighboring gene mitogen-activated protein kinase 8 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene protein tyrosine phosphatase, non-receptor type 20 Neighboring gene predicted gene, 26228

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The second PDZ domain of scaffold protein Frmpd2 binds to GluN2A of NMDA receptors. Lu X, et al. Biochem Biophys Res Commun, 2019 Aug 13. PMID 31196628
  2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
FERM and PDZ domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33193475..33297226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316244.2 → XP_017171733.1  FERM and PDZ domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    A0A140LI67
    Conserved Domains (6) summary
    smart00228
    Location:930 → 1018
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:334 → 538
    B41; Band 4.1 homologues
    cd00992
    Location:775 → 859
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:534 → 635
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:6 → 188
    PKc_like; Protein Kinases, catalytic domain
    cl28922
    Location:329 → 422
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_036158980.1 → XP_036014873.1  FERM and PDZ domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A0A140LI67
    Related
    ENSMUSP00000146693.2, ENSMUST00000208577.2
    Conserved Domains (6) summary
    smart00228
    Location:930 → 1018
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:334 → 538
    B41; Band 4.1 homologues
    cd00992
    Location:775 → 859
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:534 → 635
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:6 → 188
    PKc_like; Protein Kinases, catalytic domain
    cl28922
    Location:329 → 422
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_036158982.1 → XP_036014875.1  FERM and PDZ domain-containing protein 2 isoform X3

    UniProtKB/Swiss-Prot
    A0A140LI67
    Conserved Domains (6) summary
    smart00228
    Location:912 → 1000
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    smart00295
    Location:334 → 538
    B41; Band 4.1 homologues
    cd00992
    Location:757 → 841
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl17171
    Location:534 → 635
    PH-like; Pleckstrin homology-like domain
    cl21453
    Location:6 → 188
    PKc_like; Protein Kinases, catalytic domain
    cl28922
    Location:329 → 422
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A140LI67.1 GenPept UniProtKB/Swiss-Prot:A0A140LI67

Gene LinkOut

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Chemical Information
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