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Tmem229b transmembrane protein 229B [ Mus musculus (house mouse) ]

Gene ID: 268567, updated on 2-Nov-2024

Summary

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Official Symbol
Tmem229bprovided by MGI
Official Full Name
transmembrane protein 229Bprovided by MGI
Primary source
MGI:MGI:2444389
See related
Ensembl:ENSMUSG00000046157 AllianceGenome:MGI:2444389
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830138K24; 6330442E10Rik
Summary
Acts upstream of or within macrophage activation and response to bacterium. Predicted to be located in membrane. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human TMEM229B (transmembrane protein 229B). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in thymus adult (RPKM 17.0), CNS E18 (RPKM 15.4) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Tmem229b in Genome Data Viewer
Location:
12 C3; 12 35.51 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79008569..79054333, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78961795..79007559, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pleckstrin 2 Neighboring gene STARR-seq mESC enhancer starr_32580 Neighboring gene predicted gene, 46359 Neighboring gene STARR-seq mESC enhancer starr_32581 Neighboring gene predicted gene, 46360 Neighboring gene STARR-seq mESC enhancer starr_32582 Neighboring gene STARR-seq mESC enhancer starr_32583 Neighboring gene STARR-seq mESC enhancer starr_32585 Neighboring gene STARR-seq mESC enhancer starr_32589 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 Neighboring gene predicted gene, 53729 Neighboring gene RIKEN cDNA 9230116L04 gene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MiR-505 promotes M2 polarization in choroidal neovascularization model mice by targeting transmembrane protein 229B. Zhao S, et al. Scand J Immunol, 2019 Dec. PMID 31544253
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
  4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our data have uncovered the critical contribution of miR-505 in AMD, which is predominantly mediated by downregulation of TMEM229B.
    Title: MiR-505 promotes M2 polarization in choroidal neovascularization model mice by targeting transmembrane protein 229B.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within macrophage activation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 229B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170401.2 → NP_001163872.1  transmembrane protein 229B

    See identical proteins and their annotated locations for NP_001163872.1

    Status: VALIDATED

    Source sequence(s)
    AC165249, BC057677
    Consensus CDS
    CCDS26005.1
    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Related
    ENSMUSP00000070637.8, ENSMUST00000070174.14
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  2. NM_001364891.1 → NP_001351820.1  transmembrane protein 229B

    Status: VALIDATED

    Source sequence(s)
    AC165249
    Consensus CDS
    CCDS26005.1
    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  3. NM_001364892.1 → NP_001351821.1  transmembrane protein 229B

    Status: VALIDATED

    Source sequence(s)
    AC165249
    Consensus CDS
    CCDS26005.1
    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Related
    ENSMUSP00000134376.2, ENSMUST00000174072.8
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  4. NM_178745.5 → NP_848860.1  transmembrane protein 229B

    See identical proteins and their annotated locations for NP_848860.1

    Status: VALIDATED

    Source sequence(s)
    BC057677, BC066067
    Consensus CDS
    CCDS26005.1
    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Related
    ENSMUSP00000053835.7, ENSMUST00000056660.13
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    79008569..79054333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515914.2 → XP_006515977.1  transmembrane protein 229B isoform X1

    See identical proteins and their annotated locations for XP_006515977.1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  2. XM_030246737.1 → XP_030102597.1  transmembrane protein 229B isoform X1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Related
    ENSMUSP00000134348.2, ENSMUST00000174697.2
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  3. XM_006515913.3 → XP_006515976.1  transmembrane protein 229B isoform X1

    See identical proteins and their annotated locations for XP_006515976.1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  4. XM_006515909.3 → XP_006515972.1  transmembrane protein 229B isoform X1

    See identical proteins and their annotated locations for XP_006515972.1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  5. XM_006515915.5 → XP_006515978.1  transmembrane protein 229B isoform X1

    See identical proteins and their annotated locations for XP_006515978.1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  6. XM_030246736.2 → XP_030102596.1  transmembrane protein 229B isoform X1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  7. XM_036157432.1 → XP_036013325.1  transmembrane protein 229B isoform X1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  8. XM_036157433.1 → XP_036013326.1  transmembrane protein 229B isoform X1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  9. XM_036157434.1 → XP_036013327.1  transmembrane protein 229B isoform X1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  10. XM_030246734.1 → XP_030102594.1  transmembrane protein 229B isoform X1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV

  11. XM_030246735.2 → XP_030102595.1  transmembrane protein 229B isoform X1

    UniProtKB/Swiss-Prot
    Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
    Conserved Domains (1) summary
    cl26964
    Location:50 → 135
    ABC_trans_CmpB; Putative ABC-transporter type IV
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFQ2.1 GenPept UniProtKB/Swiss-Prot:Q8BFQ2

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