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SNORA69 small nucleolar RNA, H/ACA box 69 [ Homo sapiens (human) ]

Gene ID: 26779, updated on 10-Oct-2023

Summary

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Official Symbol
SNORA69provided by HGNC
Official Full Name
small nucleolar RNA, H/ACA box 69provided by HGNC
Primary source
HGNC:HGNC:10226
See related
Ensembl:ENSG00000206622 AllianceGenome:HGNC:10226
Gene type
snoRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
U69; U69A; RNU69
Summary
This gene encodes a member of the family of box ACA small nucleolar RNAs, characterized by a consensus ACA motif positioned 3 nucleotides from the 3' end of the RNAs and a double-hairpin structure. The box ACA small nucleolar RNAs may play a role in rRNA maturation. This gene is co-transcribed with the ribosomal protein L39 gene. [provided by RefSeq, Oct 2009]
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Genomic context

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Location:
Xq24
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (119787353..119787484, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (118162477..118162608, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (118921316..118921447, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene septin 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29887 Neighboring gene microRNA 766 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:118811626-118812126 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29888 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29891 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20963 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20964 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20965 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29897 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:118902711-118903910 Neighboring gene sosondowah ankyrin repeat domain family member D Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29899 Neighboring gene uncharacterized LOC107985694 Neighboring gene ribosomal protein L39 Neighboring gene Sharpr-MPRA regulatory region 4463 Neighboring gene UPF3B, regulator of nonsense mediated mRNA decay pseudogene Neighboring gene UPF3B regulator of nonsense mediated mRNA decay

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pseudouridine distribution in mammalian 18 S ribosomal RNA. A major cluster in the central region of the molecule. Maden EH, et al. Biochem J, 1988 Jan 15. PMID 3342024, Free PMC Article
  2. The family of box ACA small nucleolar RNAs is defined by an evolutionarily conserved secondary structure and ubiquitous sequence elements essential for RNA accumulation. Ganot P, et al. Genes Dev, 1997 Apr 1. PMID 9106664
  3. Site-specific pseudouridine formation in preribosomal RNA is guided by small nucleolar RNAs. Ganot P, et al. Cell, 1997 May 30. PMID 9182768
  4. snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs. Lestrade L, et al. Nucleic Acids Res, 2006 Jan 1. PMID 16381836, Free PMC Article
  5. Human box H/ACA pseudouridylation guide RNA machinery. Kiss AM, et al. Mol Cell Biol, 2004 Jul. PMID 15199136, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • U69 small nucleolar RNA
  • U69 snoRNA
  • U69a small nucleolar RNA

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_002584.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    Y11163
    Related
    ENST00000383895.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    119787353..119787484 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    118162477..118162608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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