rab-10 Ras-related protein Rab-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: rab-10
Official Full Name: Ras-related protein Rab-10
Primary source: WormBase:WBGene00004273
Locus tag: CELE_T23H2.5
See related: AllianceGenome:WB:WBGene00004273
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables GTPase activating protein binding activity and ankyrin repeat binding activity. Involved in several processes, including endocytic recycling; negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; and presynaptic dense core vesicle exocytosis. Located in several cellular components, including Golgi medial cisterna; cholinergic synapse; and cytoplasmic vesicle. Is expressed in several structures, including PVD; coelomocyte; hermaphrodite gonad; hypodermis; and somatic nervous system. Orthologous to human RAB10 (RAB10, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rab-10 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 4

Sequence:: Chromosome: I; NC_003279.8 (6457282..6458479, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB-10 GTPase cycling was required to control the size of GFP::ATG-9 foci. Collectively, these data support a model where rab-10 controls autophagic flux by regulating autophagosome formation and maturation.
Title: The recycling endosome protein RAB-10 promotes autophagic flux and localization of the transmembrane protein ATG-9.
dendritic branch distribution depends on the balance between the molecular motors UNC-116 and dynein, and we propose that RAB-10 regulates dendrite morphology by balancing the activity of these motors to the transmembrane receptor DMA-1.
Title: RAB-10 Regulates Dendritic Branching by Balancing Dendritic Transport.
Together these results suggest a crucial role for the Rab10 GTPase and the exocyst complex in controlling membrane transport from the secretory and/or endosomal compartments that is required for dendritic growth
Title: RAB-10-Dependent Membrane Transport Is Required for Dendrite Arborization.
the loss of TBC-2 or AMPH-1 leads to abnormally high spatial overlap of RAB-5 and RAB-10. RAB-10 and AMPH-1 mediated down-regulation of RAB-5 is an important step in recycling, required for cargo exit from early endosomes
Title: Basolateral Endocytic Recycling Requires RAB-10 and AMPH-1 Mediated Recruitment of RAB-5 GAP TBC-2 to Endosomes.
SEC-10 coordinates with RAB-10 and microtubules to form the endosomal tubular network for efficient recycling of particular clathrin-independent endocytic cargoes.
Title: SEC-10 and RAB-10 coordinate basolateral recycling of clathrin-independent cargo through endosomal tubules in Caenorhabditis elegans.
RAB-5 and RAB-10 cooperate to locally exclude each other at an essential stage during DCV sorting.
Title: RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans.
Our studies identify a RAB-10-to-ARF-6 regulatory loop required to regulate endosomal PI(4,5)P2, a key phosphoinositide in membrane traffic.
Title: RAB-10-GTPase-mediated regulation of endosomal phosphatidylinositol-4,5-bisphosphate.
The findings identify novel, potential regulators for exocyst function and show that exoc-7 and exoc-8 are functionally linked to rab-10 in endosomal trafficking in intestinal epithelial cells in C. elegans.
Title: Exocyst subunits Exo70 and Exo84 cooperate with small GTPases to regulate behavior and endocytic trafficking in C. elegans.
Results indicate that RAB-10 and EHBP-1 function together in many cell types and suggests that there are differences in the level of redundancy among Rab family members in polarized versus nonpolarized cells.
Title: EHBP-1 functions with RAB-10 during endocytic recycling in Caenorhabditis elegans.
RAB-10 protein as a key regulator of endocytic recycling upstream of RME-1 in polarized epithelial cells of the Caenorhabditis elegans intestine.
Title: RAB-10 is required for endocytic recycling in the Caenorhabditis elegans intestine.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T23H2.5 (e-PCR)
- UniSTS:317149

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activating protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables ankyrin repeat binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in endocytic recycling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in localization within membrane	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of establishment of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in presynaptic dense core vesicle exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor recycling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi medial cisterna	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cholinergic synapse	IDA Inferred from Direct Assay more info	PubMed
located_in cholinergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	IEA Inferred from Electronic Annotation more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane bounded cell projection	IEA Inferred from Electronic Annotation more info
located_in presynapse	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in secretory vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Ras-related protein Rab-10

NP_491857.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

6457282..6458479 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059456.7 → NP_491857.1 Ras-related protein Rab-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491857.1

Status: REVIEWED

UniProtKB/Swiss-Prot

I7FXD6, Q94148

Conserved Domains (2) summary

smart00175
Location:10 → 173

RAB; Rab subfamily of small GTPases

cd01867
Location:7 → 173

Rab8_Rab10_Rab13_like; Rab GTPase families 8, 10, 13 (Rab8, Rab10, Rab13)