U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Slc12a8 solute carrier family 12, member 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266733, updated on 28-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
Slc12a8provided by RGD
Official Full Name
solute carrier family 12, member 8provided by RGD
Primary source
RGD:628730
See related
EnsemblRapid:ENSRNOG00000001792 AllianceGenome:RGD:628730
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ccc9
Summary
Predicted to enable potassium:chloride symporter activity. Predicted to be involved in several processes, including chloride ion homeostasis; monoatomic ion transmembrane transport; and potassium ion homeostasis. Predicted to be located in membrane. Orthologous to human SLC12A8 (solute carrier family 12 member 8). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward (RPKM 115.9) See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Slc12a8 in Genome Data Viewer
Location:
11q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (80622000..80771674, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (67116876..67266548, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (70344771..70499202, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene mucin 13, cell surface associated Neighboring gene heart development protein with EGF-like domains 1 Neighboring gene uncharacterized LOC134481081 Neighboring gene uncharacterized LOC134481082 Neighboring gene zinc finger protein 148 Neighboring gene small nucleolar RNA SNORA36 family

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
solute carrier family 12 member 8
Names
cation-chloride cotransporter 9
solute carrier family 12 (potassium/chloride transporters), member 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153625.2 → NP_705889.2  solute carrier family 12 member 8

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000011
    UniProtKB/Swiss-Prot
    Q8CJI2, Q8CJI3
    UniProtKB/TrEMBL
    A6IRK4, F1M7M6
    Related
    ENSRNOP00000002439.6, ENSRNOT00000002439.9
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 420
    2a30; K-Cl cotransporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    80622000..80771674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006248423.5 → XP_006248485.1  solute carrier family 12 member 8 isoform X1

    See identical proteins and their annotated locations for XP_006248485.1

    UniProtKB/Swiss-Prot
    Q8CJI2, Q8CJI3
    UniProtKB/TrEMBL
    A6IRK4, F1M7M6
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 420
    2a30; K-Cl cotransporter

  2. XM_063270314.1 → XP_063126384.1  solute carrier family 12 member 8 isoform X1

    UniProtKB/TrEMBL
    A6IRK4, F1M7M6
    Related
    ENSRNOP00000081818.2, ENSRNOT00000108813.2

  3. XM_039088051.2 → XP_038943979.1  solute carrier family 12 member 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G6I7, A6IRK9
    Conserved Domains (1) summary
    TIGR00930
    Location:34 → 420
    2a30; K-Cl cotransporter

  4. XM_039088052.2 → XP_038943980.1  solute carrier family 12 member 8 isoform X3

    UniProtKB/TrEMBL
    A0A0G2K244
    Conserved Domains (1) summary
    TIGR00930
    Location:49 → 264
    2a30; K-Cl cotransporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CJI3.1 GenPept UniProtKB/Swiss-Prot:Q8CJI3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools