St18 ST18 C2H2C-type zinc finger transcription factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: St18provided by RGD
Official Full Name: ST18 C2H2C-type zinc finger transcription factorprovided by RGD
Primary source: RGD:708566
See related: EnsemblRapid:ENSRNOG00000006200 AllianceGenome:RGD:708566
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nzf3; r-MyT3
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be part of protein-DNA complex. Predicted to be active in nucleus. Orthologous to human ST18 (ST18 C2H2C-type zinc finger transcription factor). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Brain (RPKM 56.6), Adrenal (RPKM 9.4) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 5q12

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (17369383..17701094, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (12582493..12914221, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (12437617..12787223, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ST18 expression and activity are increased in cytotoxic conditions in pancreatic beta-cells. Overexpression of ST18 causes apoptosis.
Title: A critical role for the neural zinc factor ST18 in pancreatic β-cell apoptosis.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IC Inferred by Curator more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in interleukin-1-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-1-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in tumor necrosis factor-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: suppression of tumorigenicity 18 protein

Names: C2-HC type zinc finger protein r-MyT3; NZF-3; ST18, C2H2C-type zinc finger; neural zinc finger factor 3; suppression of tumorigenicity protein 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153310.2 → NP_695222.2 suppression of tumorigenicity 18 protein

Status: VALIDATED

Source sequence(s)

AF031942, CO394514, U67080

UniProtKB/TrEMBL

A0A0G2KAF8

Related

ENSRNOP00000056380.3, ENSRNOT00000059625.5

Conserved Domains (3) summary

pfam01530
Location:764 → 790

zf-C2HC; Zinc finger, C2HC type

pfam08474
Location:477 → 712

MYT1; Myelin transcription factor 1

cl01483
Location:920 → 1003

Com_YlbF; Control of competence regulator ComK, YlbF/YmcA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

17369383..17701094 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017593173.3 → XP_017448662.1 suppression of tumorigenicity 18 protein isoform X1

UniProtKB/TrEMBL

A0A0G2KAF8, A6JFH7, D3ZTP6

Conserved Domains (3) summary

pfam01530
Location:764 → 792

zf-C2HC; Zinc finger, C2HC type

pfam08474
Location:477 → 712

MYT1; Myelin transcription factor 1

cl01483
Location:920 → 1003

Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
XM_039109332.1 → XP_038965260.1 suppression of tumorigenicity 18 protein isoform X1

UniProtKB/TrEMBL

A0A0G2KAF8, A6JFH7, D3ZTP6

Conserved Domains (3) summary

pfam01530
Location:764 → 792

zf-C2HC; Zinc finger, C2HC type

pfam08474
Location:477 → 712

MYT1; Myelin transcription factor 1

cl01483
Location:920 → 1003

Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
XM_063287207.1 → XP_063143277.1 suppression of tumorigenicity 18 protein isoform X2

UniProtKB/TrEMBL

A6JFH8
XM_063287208.1 → XP_063143278.1 suppression of tumorigenicity 18 protein isoform X2

UniProtKB/TrEMBL

A6JFH8
XM_008763490.4 → XP_008761712.1 suppression of tumorigenicity 18 protein isoform X1

See identical proteins and their annotated locations for XP_008761712.1

UniProtKB/TrEMBL

A0A0G2KAF8, A6JFH7, D3ZTP6

Conserved Domains (3) summary

pfam01530
Location:764 → 792

zf-C2HC; Zinc finger, C2HC type

pfam08474
Location:477 → 712

MYT1; Myelin transcription factor 1

cl01483
Location:920 → 1003

Com_YlbF; Control of competence regulator ComK, YlbF/YmcA
XM_063287209.1 → XP_063143279.1 suppression of tumorigenicity 18 protein isoform X2

UniProtKB/TrEMBL

A6JFH8
XM_063287205.1 → XP_063143275.1 suppression of tumorigenicity 18 protein isoform X1

UniProtKB/TrEMBL

A6JFH7, D3ZTP6
XM_063287206.1 → XP_063143276.1 suppression of tumorigenicity 18 protein isoform X1

UniProtKB/TrEMBL

A6JFH7, D3ZTP6