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Riox2 ribosomal oxygenase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266670, updated on 18-Sep-2024

Summary

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Official Symbol
Riox2provided by RGD
Official Full Name
ribosomal oxygenase 2provided by RGD
Primary source
RGD:708521
See related
EnsemblRapid:ENSRNOG00000001680 AllianceGenome:RGD:708521
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mina53
Summary
Predicted to enable histone demethylase activity; identical protein binding activity; and transcription corepressor activity. Involved in cell population proliferation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in nucleolus. Orthologous to human RIOX2 (ribosomal oxygenase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 187.5), Heart (RPKM 90.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Riox2 in Genome Data Viewer
Location:
11q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (54327311..54353989, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (40861365..40884782, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (43006190..43028722, complement)

Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene Eph receptor A6 Neighboring gene U7 small nuclear RNA Neighboring gene ADP-ribosylation factor like GTPase 6 Neighboring gene crystallin beta-gamma domain containing 3 Neighboring gene NLR family, pyrin domain containing 4A, pseudogene 1 Neighboring gene uncharacterized LOC134480985 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho3 Neighboring gene olfactory receptor family 5 subfamily AC member 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A novel myc target gene, mina53, that is involved in cell proliferation. Tsuneoka M, et al. J Biol Chem, 2002 Sep 20. PMID 12091391
  2. Mina, an Il4 repressor, controls T helper type 2 bias. Okamoto M, et al. Nat Immunol, 2009 Aug. PMID 19561615, Free PMC Article
  3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  4. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105305

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2-oxoglutarate-dependent dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone H3K36 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K4 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-histidine dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidyl-histidine dioxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal oxygenase 2
Names
MYC-induced nuclear antigen
Mina-53
bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA
histone lysine demethylase MINA
myc induced nuclear antigen
NP_695221.1
XP_038943977.1
XP_038943978.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153309.2 → NP_695221.1  ribosomal oxygenase 2

    See identical proteins and their annotated locations for NP_695221.1

    Status: PROVISIONAL

    Source sequence(s)
    BC087650
    UniProtKB/Swiss-Prot
    Q8CFC1
    UniProtKB/TrEMBL
    A0A0A0MXT5, A6IQI7
    Related
    ENSRNOP00000081634.1, ENSRNOT00000100511.2
    Conserved Domains (1) summary
    pfam08007
    Location:51 → 364
    Cupin_4; Cupin superfamily protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086029.1 Reference GRCr8

    Range
    54327311..54353989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039088049.2 → XP_038943977.1  ribosomal oxygenase 2 isoform X1

    UniProtKB/Swiss-Prot
    Q8CFC1
    UniProtKB/TrEMBL
    A0A0A0MXT5, A6IQI7
    Conserved Domains (1) summary
    pfam08007
    Location:51 → 364
    Cupin_4; Cupin superfamily protein

  2. XM_039088050.2 → XP_038943978.1  ribosomal oxygenase 2 isoform X2

    Conserved Domains (1) summary
    pfam08007
    Location:84 → 300
    Cupin_4; Cupin superfamily protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CFC1.1 GenPept UniProtKB/Swiss-Prot:Q8CFC1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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