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SEC14L3 SEC14 like lipid binding 3 [ Homo sapiens (human) ]

Gene ID: 266629, updated on 3-Apr-2024

Summary

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Official Symbol
SEC14L3provided by HGNC
Official Full Name
SEC14 like lipid binding 3provided by HGNC
Primary source
HGNC:HGNC:18655
See related
Ensembl:ENSG00000100012 MIM:612824; AllianceGenome:HGNC:18655
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAP2
Summary
The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See SEC14L3 in Genome Data Viewer
Location:
22q12.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30447661..30472017, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30911006..30935427, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30843648..30868004, complement)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30831805-30832326 Neighboring gene SLC39A1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18838 Neighboring gene Sharpr-MPRA regulatory region 4237 Neighboring gene uncharacterized LOC105372991 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:30846973-30847332 Neighboring gene uncharacterized LOC107985579 Neighboring gene syndecan 4 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SEC14L3 plays a tumor-suppressive role in breast cancer through a Wnt/β-catenin-related way. Zhu Q, et al. Exp Cell Res, 2022 Aug 1. PMID 35447102
  2. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Ye X, et al. Mol Biol Rep, 2004 Mar. PMID 15040456
  3. Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters. Pan X, et al. Dig Liver Dis, 2022 Apr. PMID 34108094
  4. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma. Bartel S, et al. Sci Rep, 2017 Apr 6. PMID 28383034, Free PMC Article
  5. Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A. Mokashi V, et al. Biochem Biophys Res Commun, 2004 Apr 9. PMID 15033454

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEC14L3 plays a tumor-suppressive role in breast cancer through a Wnt/beta-catenin-related way.
    Title: SEC14L3 plays a tumor-suppressive role in breast cancer through a Wnt/β-catenin-related way.
  2. Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.
    Title: Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.
  3. Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli.
    Title: Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma.
  4. Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase proteins to transduce Wnt signals from Frizzled to phospholipase C (PLC).
    Title: The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca(2+) signaling.
  5. Discusses cloning of rat SEC14-like protein 3 and mentions three human SPF-related genes, known as SEC14-like protein 1, 2 and 3.
    Title: Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A.
  6. we report a human SPF/TAP homology SEC14L3 with 2082 base pairs in length and contains an open reading frame encoding a 400 amino acids protein. Analysis shows that SEC14L3 is mapped to 22q12 and expresses only in the liver
    Title: Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119366, MGC119367, MGC119368

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 

General protein information

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Preferred Names
SEC14-like protein 3
Names
SEC14-like 3
SEC14p-like protein TAP2
tocopherol-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027515.2 RefSeqGene

    Range
    5000..17788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001257378.2 → NP_001244307.1  SEC14-like protein 3 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC004832
    Consensus CDS
    CCDS58800.1
    UniProtKB/TrEMBL
    Q495V9
    Related
    ENSP00000385004.1, ENST00000402286.5
    Conserved Domains (1) summary
    smart00516
    Location:2 → 168
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

  2. NM_001257379.2 → NP_001244308.1  SEC14-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001244308.1

    Status: REVIEWED

    Source sequence(s)
    AC004832
    Consensus CDS
    CCDS58801.1
    UniProtKB/TrEMBL
    Q495V9
    Related
    ENSP00000383896.1, ENST00000401751.5
    Conserved Domains (1) summary
    smart00516
    Location:17 → 186
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

  3. NM_001257382.2 → NP_001244311.1  SEC14-like protein 3 isoform 3

    See identical proteins and their annotated locations for NP_001244311.1

    Status: REVIEWED

    Source sequence(s)
    AC004832
    Consensus CDS
    CCDS58801.1
    UniProtKB/TrEMBL
    Q495V9
    Conserved Domains (1) summary
    smart00516
    Location:17 → 186
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

  4. NM_001376914.1 → NP_001363843.1  SEC14-like protein 3 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC004832
    Consensus CDS
    CCDS93145.1
    UniProtKB/TrEMBL
    B3KYA6, B5MC44
    Related
    ENSP00000385941.1, ENST00000403066.5
    Conserved Domains (1) summary
    smart00516
    Location:17 → 186
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

  5. NM_174975.5 → NP_777635.1  SEC14-like protein 3 isoform 1

    See identical proteins and their annotated locations for NP_777635.1

    Status: REVIEWED

    Source sequence(s)
    AC004832
    Consensus CDS
    CCDS13877.1
    UniProtKB/Swiss-Prot
    E7EN74, E9PE57, Q495V8, Q495W0, Q495W1, Q9UDX4
    UniProtKB/TrEMBL
    Q6ISB2, Q6XCI7
    Related
    ENSP00000215812.5, ENST00000215812.9
    Conserved Domains (2) summary
    smart00516
    Location:76 → 245
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:13 → 59
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    30447661..30472017 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011530128.3 → XP_011528430.1  SEC14-like protein 3 isoform X1

    UniProtKB/TrEMBL
    B3KYA6
    Conserved Domains (2) summary
    smart00516
    Location:76 → 245
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:13 → 59
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    30911006..30935427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054325526.1 → XP_054181501.1  SEC14-like protein 3 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UDX4.1 GenPept UniProtKB/Swiss-Prot:Q9UDX4

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