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Slc4a9 solute carrier family 4 member 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 266612, updated on 28-Oct-2024

Summary

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Official Symbol
Slc4a9provided by RGD
Official Full Name
solute carrier family 4 member 9provided by RGD
Primary source
RGD:628811
See related
EnsemblRapid:ENSRNOG00000018525 AllianceGenome:RGD:628811
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ae4
Summary
Enables chloride:bicarbonate antiporter activity. Involved in monoatomic anion transport and sodium ion transmembrane transport. Located in basolateral plasma membrane. Orthologous to human SLC4A9 (solute carrier family 4 member 9). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Restricted expression toward (RPKM 127.7) See more
Orthologs
human mouse all
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Genomic context

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See Slc4a9 in Genome Data Viewer
Location:
18p11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28402793..28418638)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28128740..28144554)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29352596..29373603)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene prefoldin subunit 1 Neighboring gene heparin-binding EGF-like growth factor Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. AE4 is a DIDS-sensitive Cl(-)/HCO(-)(3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. Ko SB, et al. Am J Physiol Cell Physiol, 2002 Oct. PMID 12225984
  2. A SCL4A10 gene product maps selectively to the basolateral plasma membrane of choroid plexus epithelial cells. Praetorius J, et al. Am J Physiol Cell Physiol, 2004 Mar. PMID 14592810
  3. Distal renal tubular acidosis in mice lacking the AE1 (band3) Cl-/HCO3- exchanger (slc4a1). Stehberger PA, et al. J Am Soc Nephrol, 2007 May. PMID 17409310
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables chloride:bicarbonate antiporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables chloride:bicarbonate antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium,bicarbonate:chloride antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium,bicarbonate:chloride antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium:bicarbonate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:bicarbonate symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables sodium:bicarbonate symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium:bicarbonate symporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in bicarbonate transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in bicarbonate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic anion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in saliva secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in saliva secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sodium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in apical part of cell IEA
Inferred from Electronic Annotation
more info
  
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
anion exchange protein 4
Names
AE 4
anion exchanger 4
solute carrier family 4, sodium bicarbonate cotransporter, member 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152938.2 → NP_690921.2  anion exchange protein 4

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/Swiss-Prot
    Q8K4V2
    UniProtKB/TrEMBL
    A6J313, F1LR96
    Related
    ENSRNOP00000025137.5, ENSRNOT00000025137.8
    Conserved Domains (1) summary
    cl26877
    Location:53 → 908
    Band_3_cyto; Band 3 cytoplasmic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    28402793..28418638
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063277134.1 → XP_063133204.1  anion exchange protein 4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4V2.1 GenPept UniProtKB/Swiss-Prot:Q8K4V2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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