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Cdk8 cyclin dependent kinase 8 [ Mus musculus (house mouse) ]

Gene ID: 264064, updated on 14-Nov-2024

Summary

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Official Symbol
Cdk8provided by MGI
Official Full Name
cyclin dependent kinase 8provided by MGI
Primary source
MGI:MGI:1196224
See related
Ensembl:ENSMUSG00000029635 AllianceGenome:MGI:1196224
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in G1/S transition of mitotic cell cycle and positive regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in embryo; tibialis anterior; and tongue. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in adrenal adult (RPKM 21.2), ovary adult (RPKM 18.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Cdk8 in Genome Data Viewer
Location:
5 G3; 5 85.19 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (146167432..146239684)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (146230795..146302874)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4806 Neighboring gene ring finger protein (C3H2C3 type) 6 Neighboring gene predicted gene, 38745 Neighboring gene predicted gene, 52832 Neighboring gene predicted gene, 38747

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. NK Cell-Specific CDK8 Deletion Enhances Antitumor Responses. Witalisz-Siepracka A, et al. Cancer Immunol Res, 2018 Apr. PMID 29386186
  2. The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis. Yamada T, et al. Stem Cell Reports, 2022 Jul 12. PMID 35777359, Free PMC Article
  3. Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells. Halter K, et al. Chromosome Res, 2024 Oct 10. PMID 39390295, Free PMC Article
  4. Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems. Li J, et al. Cell Rep, 2023 Jun 27. PMID 37235474
  5. MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway. Lv Y, et al. Genes Cells, 2021 Oct. PMID 34228857

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.
    Title: Cdk8 and Hira mutations trigger X chromosome elimination in naive female hybrid mouse embryonic stem cells.
  2. Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems.
    Title: Transcriptome-based chemical screens identify CDK8 as a common barrier in multiple cell reprogramming systems.
  3. CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
    Title: CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.
  4. The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis.
    Title: The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis.
  5. MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway.
    Title: MiR-382-5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway.
  6. Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.
    Title: Cdk8 is required for establishment of H3K27me3 and gene repression by Xist and mouse development.
  7. MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8.
    Title: MiR-297 alleviates LPS-induced A549 cell and mice lung injury via targeting cyclin dependent kinase 8.
  8. CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic beta Cells.
    Title: CDK8 Regulates Insulin Secretion and Mediates Postnatal and Stress-Induced Expression of Neuropeptides in Pancreatic β Cells.
  9. FBXL19 and CDK-Mediator support long-range interactions between silent gene promoters that rely on FBXL19 for their induction during differentiation and gene regulatory elements.
    Title: CDK-Mediator and FBXL19 prime developmental genes for activation by promoting atypical regulatory interactions.
  10. Both genetic and pharmacological inhibition of CDK8 and its homologous twin kinase CDK19 leads to abrogation of BMP4-induced EMT.
    Title: Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.
Submit: New GeneRIF Correction See all GeneRIFs (23)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37111

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S2 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S5 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat S7 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat T4 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II CTD heptapeptide repeat Y1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cyclin-dependent protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CKM complex IEA
Inferred from Electronic Annotation
more info
  
part_of CKM complex ISO
Inferred from Sequence Orthology
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex ISO
Inferred from Sequence Orthology
more info
  
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of mediator complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cyclin-dependent kinase 8
Names
cell division protein kinase 8
mediator complex subunit CDK8
mediator of RNA polymerase II transcription subunit CDK8
NP_001346919.1
NP_001346920.1
NP_705827.2
XP_006504899.1
XP_006504901.1
XP_006504902.1
XP_006504903.1
XP_030110375.1
XP_036021035.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359990.1 → NP_001346919.1  cyclin-dependent kinase 8 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC113316
    Conserved Domains (1) summary
    cd07868
    Location:3 → 335
    STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

  2. NM_001359991.1 → NP_001346920.1  cyclin-dependent kinase 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC113316, AK131948
    Consensus CDS
    CCDS90018.1
    UniProtKB/TrEMBL
    E9Q6E2
    Related
    ENSMUSP00000125668.2, ENSMUST00000161181.8
    Conserved Domains (1) summary
    cl21453
    Location:1 → 270
    PKc_like; Protein Kinases, catalytic domain

  3. NM_153599.4 → NP_705827.2  cyclin-dependent kinase 8 isoform 1

    See identical proteins and their annotated locations for NP_705827.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC113316
    Consensus CDS
    CCDS19869.1
    UniProtKB/Swiss-Prot
    Q8R3L8
    Related
    ENSMUSP00000031640.9, ENSMUST00000031640.15
    Conserved Domains (1) summary
    cd07868
    Location:3 → 335
    STKc_CDK8; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    146167432..146239684
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504836.5 → XP_006504899.1  cyclin-dependent kinase 8 isoform X1

    UniProtKB/Swiss-Prot
    Q8R3L8
    Conserved Domains (1) summary
    cl21453
    Location:3 → 330
    PKc_like; Protein Kinases, catalytic domain

  2. XM_006504840.5 → XP_006504903.1  cyclin-dependent kinase 8 isoform X5

    Conserved Domains (1) summary
    cl21453
    Location:3 → 287
    PKc_like; Protein Kinases, catalytic domain

  3. XM_030254515.2 → XP_030110375.1  cyclin-dependent kinase 8 isoform X6

    Conserved Domains (1) summary
    cl21453
    Location:3 → 287
    PKc_like; Protein Kinases, catalytic domain

  4. XM_006504838.5 → XP_006504901.1  cyclin-dependent kinase 8 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:3 → 322
    PKc_like; Protein Kinases, catalytic domain

  5. XM_006504839.5 → XP_006504902.1  cyclin-dependent kinase 8 isoform X3

    Conserved Domains (1) summary
    cl21453
    Location:3 → 298
    PKc_like; Protein Kinases, catalytic domain

  6. XM_036165142.1 → XP_036021035.1  cyclin-dependent kinase 8 isoform X4

    Conserved Domains (1) summary
    cl21453
    Location:3 → 298
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_181570.1: Suppressed sequence

    Description
    NM_181570.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R3L8.3 GenPept UniProtKB/Swiss-Prot:Q8R3L8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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