Map2k3 mitogen-activated protein kinase kinase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Map2k3provided by MGI
Official Full Name: mitogen-activated protein kinase kinase 3provided by MGI
Primary source: MGI:MGI:1346868
See related: Ensembl:ENSMUSG00000018932 AllianceGenome:MGI:1346868
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MEK3; MKK3; MKK3b; Prkmk3; MAPKK 3
Summary: Enables MAP kinase kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 35.9), small intestine adult (RPKM 30.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.95 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (60822880..60843637)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (60932054..60952811)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis.
Title: Circulating free heme induces cytokine storm and pulmonary hypertension through the MKK3/p38 axis.
Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C-terminal AAs 2-5 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly.
Title: Receptor for advanced glycation end products aggravates cognitive deficits in type 2 diabetes through binding of C-terminal AAs 2-5 to mitogen-activated protein kinase kinase 3 (MKK3) and facilitation of MEKK3-MKK3-p38 module assembly.
By regulating the TGFbeta1/TAK1/MMK3/p38MAPK signaling pathway.
Title: Incremental load training improves renal fibrosis by regulating the TGF‑β1/TAK1/MKK3/p38MAPK signaling pathway and inducing the activation of autophagy in aged mice.
The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke.
Title: MKK3 influences mitophagy and is involved in cigarette smoke-induced inflammation.
MAP2K6 functions in mouse testis determination, via positive effects on Sry, and a minor role for MAP2K3.
Title: Genetic Analyses Reveal Functions for MAP2K3 and MAP2K6 in Mouse Testis Determination.
ATF3 upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 expression and subsequent p38-transforming growth factor-beta signaling.
Title: Cardiac Fibroblast-Specific Activating Transcription Factor 3 Protects Against Heart Failure by Suppressing MAP2K3-p38 Signaling.
miR-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 and TNF-alpha, in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.
Title: Elevation of miR-21, through targeting MKK3, may be involved in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.
miR-21a-5p inhibited BPA induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK in 3T3-L1 cells
Title: MiR-21a-5p suppresses bisphenol A-induced pre-adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK.
this study demonstrates that MKK3 influences mitochondrial quality by affecting the expression of mitochondrial proteins, including TCA cycle enzymes, and mitophagy, which consequently regulates the inflammatory response.
Title: MKK3 deletion improves mitochondrial quality.
Exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 pathway.
Title: Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Map2k3 (e-PCR), detects polymorphism
- UniSTS:507043

MAP2K3_360 (e-PCR)
- UniSTS:277467

RH126082 (e-PCR)
- UniSTS:162794

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables MAP kinase kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase kinase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cardiac muscle contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to sorbitol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to vascular endothelial growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of hippo signaling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in p38MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in p38MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of MAPK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ischemia	IEA Inferred from Electronic Annotation more info
involved_in stress-activated protein kinase signaling cascade	IEA Inferred from Electronic Annotation more info
involved_in stress-activated protein kinase signaling cascade	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dual specificity mitogen-activated protein kinase kinase 3

Names: MAP kinase kinase 3; MAPK/ERK kinase 3

NP_032954.1

EC 2.7.12.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_008928.5 → NP_032954.1 dual specificity mitogen-activated protein kinase kinase 3

See identical proteins and their annotated locations for NP_032954.1

Status: VALIDATED

Source sequence(s)

AL603830

Consensus CDS

CCDS24804.1

UniProtKB/Swiss-Prot

O09110, P97293, Q91VX1

UniProtKB/TrEMBL

Q3TLX7, Q3TX82, Q3UDI2, Q5SWN9

Related

ENSMUSP00000019076.4, ENSMUST00000019076.10

Conserved Domains (1) summary

cd06617
Location:62 → 344

PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6