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GNL3 G protein nucleolar 3 [ Homo sapiens (human) ]

Gene ID: 26354, updated on 3-Nov-2024

Summary

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Official Symbol
GNL3provided by HGNC
Official Full Name
G protein nucleolar 3provided by HGNC
Primary source
HGNC:HGNC:29931
See related
Ensembl:ENSG00000163938 MIM:608011; AllianceGenome:HGNC:29931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NS; Nug1; E2IG3; NNP47; C77032
Summary
The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in urinary bladder (RPKM 35.8), prostate (RPKM 32.9) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See GNL3 in Genome Data Viewer
Location:
3p21.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (52685920..52694497)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (52718831..52727408)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52719936..52728513)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 856, pseudogene Neighboring gene RNA, U6atac small nuclear 16, pseudogene Neighboring gene polybromo 1 Neighboring gene MPRA-validated peak4655 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52699923-52700424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52700425-52700924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19944 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52719523-52720211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19945 Neighboring gene small nucleolar RNA, C/D box 136 Neighboring gene small nucleolar RNA, C/D box 19B Neighboring gene small nucleolar RNA, C/D box 19C Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14452 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52749367-52749954 Neighboring gene signal peptidase complex subunit 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:52765581-52766780 Neighboring gene zinc finger protein 610 pseudogene Neighboring gene NIMA related kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Association of a murine leukaemia stem cell gene signature based on nucleostemin promoter activity with prognosis of acute myeloid leukaemia in patients. Ali MA, et al. Biochem Biophys Res Commun, 2014 Jul 18. PMID 24960197
  2. Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population. Wang X, et al. Sci Rep, 2022 Sep 27. PMID 36167888, Free PMC Article
  3. [Gene profiling after knocking-down the expression of NS gene in prostate cancer PC-3 cells]. Liu RL, et al. Zhonghua Zhong Liu Za Zhi, 2009 Aug. PMID 20021940
  4. Differential expression of nucleostemin, a stem cell marker, and its variants in different types of brain tumors. Malakootian M, et al. Mol Carcinog, 2010 Sep. PMID 20572164
  5. Proteomic Investigation of the Role of Nucleostemin in Nucleophosmin-Mutated OCI-AML 3 Cell Line. Cela I, et al. Int J Mol Sci, 2022 Jul 11. PMID 35886999, Free PMC Article

See all (272) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of GNL3 inhibits LUAD cell growth by regulating Wnt-beta-catenin pathway.
    Title: Knockdown of GNL3 inhibits LUAD cell growth by regulating Wnt-β-catenin pathway.
  2. The nucleolar protein GNL3 prevents resection of stalled replication forks.
    Title: The nucleolar protein GNL3 prevents resection of stalled replication forks.
  3. Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population.
    Title: Common variants in GNL3 gene contributed the susceptibility of hand osteoarthritis in Han Chinese population.
  4. Proteomic Investigation of the Role of Nucleostemin in Nucleophosmin-Mutated OCI-AML 3 Cell Line.
    Title: Proteomic Investigation of the Role of Nucleostemin in Nucleophosmin-Mutated OCI-AML 3 Cell Line.
  5. Association of Nucleostemin Polymorphisms with Chronic Hepatitis B Virus Infection in Chinese Han Population.
    Title: Association of Nucleostemin Polymorphisms with Chronic Hepatitis B Virus Infection in Chinese Han Population.
  6. Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma.
    Title: Nucleostemin upregulation and STAT3 activation as early events in oral epithelial dysplasia progression to squamous cell carcinoma.
  7. RNA-seq reveal RNA binding protein GNL3 as a key mediator in the development of psoriasis vulgaris by regulating the IL23/IL17 axis.
    Title: RNA-seq reveal RNA binding protein GNL3 as a key mediator in the development of psoriasis vulgaris by regulating the IL23/IL17 axis.
  8. G protein nucleolar 3 promotes Non-Hodgkin lymphoma progression by activating the Wnt/beta-catenin signaling pathway.
    Title: G protein nucleolar 3 promotes Non-Hodgkin lymphoma progression by activating the Wnt/β-catenin signaling pathway.
  9. Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry.
    Title: Identification of Binding Proteins for TSC22D1 Family Proteins Using Mass Spectrometry.
  10. Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder.
    Title: Integrative analyses prioritize GNL3 as a risk gene for bipolar disorder.
Submit: New GeneRIF Correction See all GeneRIFs (72)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
EBI GWAS Catalog
Genome-wide association of mood-incongruent psychotic bipolar disorder.
EBI GWAS Catalog
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
EBI GWAS Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
EBI GWAS Catalog
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human guanine nucleotide binding protein-like 3 (GNL3) at amino acid residues 509-510 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC800

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables RNA binding HDA PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of miRNA transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in stem cell division IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
  
located_in extracellular space HDA PubMed 
located_in membrane HDA PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein-like 3
Names
E2-induced gene 3 protein
estradiol-induced nucleotide binding protein
guanine nucleotide binding protein-like 3 (nucleolar)
novel nucleolar protein 47
nucleolar GTP-binding protein 3
nucleostemin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027871.1 RefSeqGene

    Range
    5113..13578
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014366.5 → NP_055181.3  guanine nucleotide-binding protein-like 3 isoform 1

    See identical proteins and their annotated locations for NP_055181.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI028402, AK027514, BC001024, CF272475
    Consensus CDS
    CCDS2861.1
    UniProtKB/Swiss-Prot
    B2RDC1, Q5PU80, Q96SV6, Q96SV7, Q9BVP2, Q9UJY0
    Related
    ENSP00000395772.1, ENST00000418458.6
    Conserved Domains (3) summary
    cd04178
    Location:142 → 307
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:133 → 419
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:16 → 85
    GN3L_Grn1; GNL3L/Grn1 putative GTPase

  2. NM_206825.2 → NP_996561.1  guanine nucleotide-binding protein-like 3 isoform 2

    See identical proteins and their annotated locations for NP_996561.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AF191018, AK027514
    Consensus CDS
    CCDS43100.1
    Related
    ENSP00000378278.2, ENST00000394799.6
    Conserved Domains (3) summary
    cd04178
    Location:130 → 295
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:121 → 407
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:4 → 73
    GN3L_Grn1; GNL3L/Grn1 putative GTPase

  3. NM_206826.1 → NP_996562.1  guanine nucleotide-binding protein-like 3 isoform 2

    See identical proteins and their annotated locations for NP_996562.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
    Source sequence(s)
    AF191018, AK027514, BC001024, BF732788
    Consensus CDS
    CCDS43100.1
    Conserved Domains (3) summary
    cd04178
    Location:130 → 295
    Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
    COG1161
    Location:121 → 407
    RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
    pfam08701
    Location:4 → 73
    GN3L_Grn1; GNL3L/Grn1 putative GTPase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    52685920..52694497
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    52718831..52727408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BVP2.2 GenPept UniProtKB/Swiss-Prot:Q9BVP2

Gene LinkOut

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Chemical Information
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