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FBXO10 F-box protein 10 [ Homo sapiens (human) ]

Gene ID: 26267, updated on 3-Apr-2024

Summary

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Official Symbol
FBXO10provided by HGNC
Official Full Name
F-box protein 10provided by HGNC
Primary source
HGNC:HGNC:13589
See related
Ensembl:ENSG00000147912 MIM:609092; AllianceGenome:HGNC:13589
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBX10; PRMT11
Summary
Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in testis (RPKM 5.1), thyroid (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9p13.2
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37510892..37576380, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37534560..37600086, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37510889..37576377, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:37477128-37478327 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37485410-37486001 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 3 Neighboring gene ribosomal protein L21 pseudogene 83 Neighboring gene RNA polymerase I subunit E Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37511563-37512119 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:37515395-37515896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28395 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28396 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28397 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28398 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28399 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28400 Neighboring gene MPRA-validated peak7234 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28401 Neighboring gene Sharpr-MPRA regulatory region 11948 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19910 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:37600233-37600415 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene RAB1C, member RAS oncogene family (pseudogene)

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL. Guo F, et al. Leukemia, 2020 Feb. PMID 31570756
  2. Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF). Xu X, et al. Mol Carcinog, 2014 Apr. PMID 23138933, Free PMC Article
  3. The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans. Wolf SS. Cell Mol Life Sci, 2009 Jul. PMID 19300908
  4. FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA. Ju UI, et al. Biochem Biophys Res Commun, 2015 Sep 4. PMID 26187670
  5. FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women. Barnholtz-Sloan JS, et al. Carcinogenesis, 2010 Aug. PMID 20554749, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL.
    Title: Recent BCR stimulation induces a negative autoregulatory loop via FBXO10 mediated degradation of HGAL.
  2. siRNA-mediated knockdown of FBXO11 facilitated HIF-1alpha expression in various cancer cells and HIF-1alpha-driven gene expressions, but the FBXO10 knockdown did not.
    Title: FBXO11 represses cellular response to hypoxia by destabilizing hypoxia-inducible factor-1α mRNA.
  3. Higher Fbxo10 expression in T cells is associated with Mcs5a increased susceptibility alleles
    Title: Human MCS5A1 candidate breast cancer susceptibility gene FBXO10 is induced by cellular stress and correlated with lens epithelium-derived growth factor (LEDGF).
  4. FBXO10, a protein related to DRE-1, binds BCL2 and promotes its degradation, thereby initiating cell death. Moreover, some diffuse large B-cell lymphomas have inactivating mutations in FBXO10 or express FBXO10 at low levels.
    Title: Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: FGFR2 and other loci identified in genome-wide association studies are associated with breast cancer in African-American and younger women.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ41992, MGC149840

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of ubiquitin ligase complex NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
F-box only protein 10
Names
F-box protein Fbx10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012166.3 → NP_036298.2  F-box only protein 10

    See identical proteins and their annotated locations for NP_036298.2

    Status: VALIDATED

    Source sequence(s)
    AB209610, AF174598, AI475671, AL513165, BU623815, CN411883
    Consensus CDS
    CCDS47966.1
    UniProtKB/Swiss-Prot
    Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3
    UniProtKB/TrEMBL
    Q59F51
    Related
    ENSP00000403802.2, ENST00000432825.7
    Conserved Domains (2) summary
    pfam12937
    Location:6 → 49
    F-box-like
    pfam13229
    Location:464 → 610
    Beta_helix; Right handed beta helix region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    37510892..37576380 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423220.1 → XP_047279176.1  F-box only protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

  2. XM_047423219.1 → XP_047279175.1  F-box only protein 10 isoform X1

  3. XM_017014619.2 → XP_016870108.1  F-box only protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3
    UniProtKB/TrEMBL
    Q59F51
    Conserved Domains (2) summary
    pfam12937
    Location:6 → 49
    F-box-like
    pfam13229
    Location:464 → 610
    Beta_helix; Right handed beta helix region

  4. XM_047423221.1 → XP_047279177.1  F-box only protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

  5. XM_005251439.6 → XP_005251496.2  F-box only protein 10 isoform X3

  6. XM_047423222.1 → XP_047279178.1  F-box only protein 10 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    37534560..37600086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362723.1 → XP_054218698.1  F-box only protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

  2. XM_054362721.1 → XP_054218696.1  F-box only protein 10 isoform X1

  3. XM_054362722.1 → XP_054218697.1  F-box only protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

  4. XM_054362724.1 → XP_054218699.1  F-box only protein 10 isoform X2

    UniProtKB/Swiss-Prot
    Q08AL3, Q08AL4, Q5JRT8, Q9UK96, Q9UKC3

  5. XM_054362725.1 → XP_054218700.1  F-box only protein 10 isoform X3

  6. XM_054362726.1 → XP_054218701.1  F-box only protein 10 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UK96.3 GenPept UniProtKB/Swiss-Prot:Q9UK96

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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