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CABYR calcium binding tyrosine phosphorylation regulated [ Homo sapiens (human) ]

Gene ID: 26256, updated on 11-Apr-2024

Summary

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Official Symbol
CABYRprovided by HGNC
Official Full Name
calcium binding tyrosine phosphorylation regulatedprovided by HGNC
Primary source
HGNC:HGNC:15569
See related
Ensembl:ENSG00000154040 MIM:612135; AllianceGenome:HGNC:15569
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT88; FSP2; CBP86; FSP-2; CABYRa; CABYRc; CABYRe; CABYRc/d
Summary
To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Expression
Restricted expression toward testis (RPKM 117.5) See more
Orthologs
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Genomic context

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See CABYR in Genome Data Viewer
Location:
18q11.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (24139062..24161600)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (24333387..24355939)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (21719026..21741564)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9361 Neighboring gene TTC39C antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13167 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9362 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9363 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13168 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13169 Neighboring gene tetratricopeptide repeat domain 39C Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13170 Neighboring gene Sharpr-MPRA regulatory region 15364 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13171 Neighboring gene RNA, U5A small nuclear 6, pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 452 Neighboring gene oxysterol binding protein like 1A Neighboring gene Sharpr-MPRA regulatory region 1293 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21776521-21777022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:21777023-21777522 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:21791138-21791312 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:21794009-21794579 Neighboring gene RNA, U6 small nuclear 435, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Upregulated calcium-binding tyrosine phosphorylation-regulated protein-a/b regulates cell proliferation and apoptosis and predicts poor prognosis in hepatocellular carcinoma. Yu XN, et al. J Cell Biochem, 2020 Apr. PMID 31692072
  2. Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation. Xiao Q, et al. Oncotarget, 2016 Feb 23. PMID 26843620, Free PMC Article
  3. Knockdown of CABYR-a/b increases chemosensitivity of human non-small cell lung cancer cells through inactivation of Akt. Qian Z, et al. Mol Cancer Res, 2014 Mar. PMID 24362251
  4. The expression and effects the CABYR-c transcript of CABYR gene in hepatocellular carcinoma. Li H, et al. Bull Cancer, 2012 Mar 1. PMID 22285430
  5. CABYR RNAi plasmid construction and NF-κB signal transduction pathway. Shi LX, et al. World J Gastroenterol, 2010 Oct 21. PMID 20954286, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulated calcium-binding tyrosine phosphorylation-regulated protein-a/b regulates cell proliferation and apoptosis and predicts poor prognosis in hepatocellular carcinoma.
    Title: Upregulated calcium-binding tyrosine phosphorylation-regulated protein-a/b regulates cell proliferation and apoptosis and predicts poor prognosis in hepatocellular carcinoma.
  2. Study of (Co-IP) and reverse co-immunoprecipitation (Co-IP) of CBP86-IV (TSCBP86-IV or CABYR) in human sperm cell lysate identified phosphoglycerate kinase 2 (PGK2) as interacting partner of CABYR. Protein interactions were further confirmed by yeast two-hybrid system.
    Title: Testis-specific calcium-binding protein CBP86-IV (CABYR) binds with phosphoglycerate kinase 2 in vitro and in vivo experiment.
  3. There is downregulation of both ROPN1 and CABYR in asthenozoospermic samples and importantly, a positive correlation between the expression of the two genes, suggesting that ROPN1 and CABYR co-expression is a prerequisite for normal flagellar function and sperm motility.
    Title: Molecular study of human sperm RNA: Ropporin and CABYR in asthenozoospermia.
  4. Low CABYR expression is associated with colon cancer.
    Title: Identification of downstream metastasis-associated target genes regulated by LSD1 in colon cancer cells.
  5. The results demonstrate that depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation.
    Title: Depletion of CABYR-a/b sensitizes lung cancer cells to TRAIL-induced apoptosis through YAP/p73-mediated DR5 upregulation.
  6. Short hairpin RNA-mediated knockdown of CABYR-a/b significantly inhibited the proliferation of NCI-H460 and A549 cells and resulted in the attenuation of Akt phosphorylation, which is constitutively active in lung cancer cells.
    Title: Knockdown of CABYR-a/b increases chemosensitivity of human non-small cell lung cancer cells through inactivation of Akt.
  7. CABYR-c is highly expressed in hepatocellular carcinoma tissues and may play an oncogenic role in heptocarcinogenesis as well as its progression.
    Title: The expression and effects the CABYR-c transcript of CABYR gene in hepatocellular carcinoma.
  8. CABYR variants form a complex not only with the scaffolding protein AKAP3 but also with another RII-like domain-containing protein in the sperm fibrous sheath.
    Title: CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath.
  9. High CABYR is associated with neoplasms.
    Title: Expression of the sperm fibrous sheath protein CABYR in human cancers and identification of α-enolase as an interacting partner of CABYR-a.
  10. The expression of NF-kappaB was not significantly affected by silencing CABYR in 293T cells.
    Title: CABYR RNAi plasmid construction and NF-κB signal transduction pathway.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9117

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in epithelial cilium movement involved in extracellular fluid movement NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in sperm capacitation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 
is_active_in sperm fibrous sheath IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm fibrous sheath IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sperm principal piece ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
calcium-binding tyrosine phosphorylation-regulated protein
Names
calcium binding tyrosine-(Y)-phosphorylation regulated (fibrousheathin 2)
calcium-binding protein 86
cancer/testis antigen 88
fibrousheathin II
fibrousheathin-2
testis tissue sperm-binding protein Li 84P
testis-specific calcium-binding protein CBP86

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308231.2 → NP_001295160.1  calcium-binding tyrosine phosphorylation-regulated protein isoform f

    See identical proteins and their annotated locations for NP_001295160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks two lacks two alternate exons in the 5' coding region, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (f) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC090772, AK225858, AK301889
    Consensus CDS
    CCDS77166.1
    UniProtKB/TrEMBL
    A0A0D9SFQ2, E2ITE0
    Related
    ENSP00000486801.1, ENST00000627314.1

  2. NM_012189.4 → NP_036321.2  calcium-binding tyrosine phosphorylation-regulated protein isoform a

    See identical proteins and their annotated locations for NP_036321.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein isoform (a).
    Source sequence(s)
    AF088868, AK225858, AK313243, BC011996, DB055487
    Consensus CDS
    CCDS11881.1
    UniProtKB/Swiss-Prot
    B2R857, O75952, Q8WXW5, Q9HAY3, Q9HAY4, Q9HAY5, Q9HCY9
    UniProtKB/TrEMBL
    A0A024RC21, E2ITE0
    Related
    ENSP00000483621.1, ENST00000621648.4
    Conserved Domains (2) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    cl26247
    Location:214 → 414
    DNA_pol3_delta2; DNA polymerase III, delta subunit

  3. NM_138643.3 → NP_619584.1  calcium-binding tyrosine phosphorylation-regulated protein isoform d

    See identical proteins and their annotated locations for NP_619584.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two internal exons in the 5' region, which results in a downstream translation start codon, and has an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The resulting isoform (d) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF295038, AK225858, BC011996, DB055487
    Consensus CDS
    CCDS11883.1
    UniProtKB/Swiss-Prot
    O75952
    Related
    ENSP00000317095.6, ENST00000327201.10

  4. NM_138644.3 → NP_619585.1  calcium-binding tyrosine phosphorylation-regulated protein isoform c

    See identical proteins and their annotated locations for NP_619585.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon and an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus compared to isoform a. Variants 3 and 7 encode the same isoform c.
    Source sequence(s)
    AF295037, AK225858, BC011996, HY051562
    Consensus CDS
    CCDS42420.1
    UniProtKB/TrEMBL
    E2ITE2
    Related
    ENSP00000382421.1, ENST00000399499.5
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  5. NM_153768.3 → NP_722452.1  calcium-binding tyrosine phosphorylation-regulated protein isoform b

    See identical proteins and their annotated locations for NP_722452.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (b) lacks an internal segment in the N-terminal region, compared to isoform a.
    Source sequence(s)
    AF329634, AK225858, AK313243, BC011996
    Consensus CDS
    CCDS11882.1
    UniProtKB/TrEMBL
    E2ITE0
    Related
    ENSP00000382404.3, ENST00000399481.6
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  6. NM_153769.3 → NP_722453.1  calcium-binding tyrosine phosphorylation-regulated protein isoform c

    See identical proteins and their annotated locations for NP_722453.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate splice site in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (c) is shorter and has a distinct C-terminus, compared to isoform a. Variants 3 and 7 encode the same isoform c.
    Source sequence(s)
    AK225858, BC011996, DB055487
    Consensus CDS
    CCDS42420.1
    UniProtKB/TrEMBL
    E2ITE2
    Related
    ENSP00000382419.3, ENST00000399496.8
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  7. NM_153770.3 → NP_722454.1  calcium-binding tyrosine phosphorylation-regulated protein isoform e

    See identical proteins and their annotated locations for NP_722454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has a alternate splice junction in the coding region, which results in a downstream translation stop codon, compared to variant 1. The encoded isoform (e) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AF295039, BC011996, DB055487
    Consensus CDS
    CCDS45840.1
    UniProtKB/Swiss-Prot
    O75952
    Related
    ENSP00000399973.2, ENST00000415309.6
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    24139062..24161600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258247.2 → XP_005258304.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X3

    UniProtKB/TrEMBL
    E2ITE2
    Conserved Domains (1) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17

  2. XM_024451160.2 → XP_024306928.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

    UniProtKB/Swiss-Prot
    B2R857, O75952, Q8WXW5, Q9HAY3, Q9HAY4, Q9HAY5, Q9HCY9
    UniProtKB/TrEMBL
    A0A024RC21, E2ITE0
    Conserved Domains (2) summary
    cd12100
    Location:10 → 48
    DD_CABYR_SP17; Dimerization/Docking domain of the sperm fibrous sheath proteins, Calcium-Binding tYrosine-phosphorylation Regulated protein and Sperm Protein 17
    cl26247
    Location:214 → 414
    DNA_pol3_delta2; DNA polymerase III, delta subunit

  3. XM_047437482.1 → XP_047293438.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

    UniProtKB/TrEMBL
    A0A0D9SFQ2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    24333387..24355939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318523.1 → XP_054174498.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X1

  2. XM_054318525.1 → XP_054174500.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X3

  3. XM_054318524.1 → XP_054174499.1  calcium-binding tyrosine phosphorylation-regulated protein isoform X2

    UniProtKB/TrEMBL
    B4DXA8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75952.2 GenPept UniProtKB/Swiss-Prot:O75952

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