U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OR2M4 olfactory receptor family 2 subfamily M member 4 [ Homo sapiens (human) ]

Gene ID: 26245, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
OR2M4provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily M member 4provided by HGNC
Primary source
HGNC:HGNC:8270
See related
Ensembl:ENSG00000171180 AllianceGenome:HGNC:8270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1-55; OST710; TPCR100; HTPCRX18; HSHTPCRX18
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q44
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (248231417..248244679)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247657538..247670800)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (248394719..248407981)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:248349804-248351003 Neighboring gene olfactory receptor family 2 subfamily M member 2 Neighboring gene olfactory receptor family 2 subfamily M member 3 Neighboring gene olfactory receptor family 2 subfamily T member 33 Neighboring gene olfactory receptor family 2 subfamily T member 12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Expression of members of the putative olfactory receptor gene family in mammalian germ cells. Parmentier M, et al. Nature, 1992 Jan 30. PMID 1370859
  2. Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. Barnes IHA, et al. BMC Genomics, 2020 Mar 3. PMID 32126975, Free PMC Article
  3. Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species. Vanderhaeghen P, et al. Genomics, 1997 Feb 1. PMID 9119360
  4. DEFOG: a practical scheme for deciphering families of genes. Fuchs T, et al. Genomics, 2002 Sep. PMID 12213199
  5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sensory perception of smell NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
olfactory receptor 2M4
Names
novel 7 transmembrane receptor (rhodopsin family) protein
olfactory receptor OR1-55
olfactory receptor TPCR100

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017504.2 → NP_059974.1  olfactory receptor 2M4

    See identical proteins and their annotated locations for NP_059974.1

    Status: VALIDATED

    Source sequence(s)
    AL450303
    Consensus CDS
    CCDS31108.1
    UniProtKB/Swiss-Prot
    Q15611, Q8NG82, Q96R27
    UniProtKB/TrEMBL
    A0A126GV73
    Related
    ENSP00000492992.1, ENST00000641868.1
    Conserved Domains (2) summary
    pfam00001
    Location:41 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34 → 305
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    248231417..248244679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247657538..247670800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96R27.2 GenPept UniProtKB/Swiss-Prot:Q96R27

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous