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Cops2 COP9 signalosome subunit 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 261736, updated on 2-Nov-2024

Summary

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Official Symbol
Cops2provided by RGD
Official Full Name
COP9 signalosome subunit 2provided by RGD
Primary source
RGD:628791
See related
EnsemblRapid:ENSRNOG00000008744 AllianceGenome:RGD:628791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CSN2; Trip15
Summary
Predicted to enable transcription corepressor activity. Involved in negative regulation of transcription by RNA polymerase II and neuron differentiation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of COP9 signalosome. Orthologous to human COPS2 (COP9 signalosome subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 355.9), Heart (RPKM 306.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cops2 in Genome Data Viewer
Location:
3q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (133537729..133563493, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (113084174..113110090, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (118109394..118137125, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene SHC adaptor protein 4 Neighboring gene EP300 interacting inhibitor of differentiation 1 Neighboring gene SECIS binding protein 2-like Neighboring gene TATA element modulatory factor 1, pseudogene 1 Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN. Alves CRR, et al. Mol Metab, 2020 Sep. PMID 32408015, Free PMC Article
  2. Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells. Akiyama H, et al. Brain Res Dev Brain Res, 2003 Jan 10. PMID 12524175
  3. Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain. Tenbaum SP, et al. Dev Biol, 2003 Feb 1. PMID 12606288
  4. The role of transcriptional corepressor Nif3l1 in early stage of neural differentiation via cooperation with Trip15/CSN2. Akiyama H, et al. J Biol Chem, 2003 Mar 21. PMID 12522100
  5. Disruption of the COP9 signalosome Csn2 subunit in mice causes deficient cell proliferation, accumulation of p53 and cyclin E, and early embryonic death. Lykke-Andersen K, et al. Mol Cell Biol, 2003 Oct. PMID 12972599, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.
    Title: Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN.
  2. Expressed at an early stage of neuronal differentiaation.
    Title: Implication of Trip15/CSN2 in early stage of neuronal differentiation of P19 embryonal carcinoma cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inner cell mass cell proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neuron differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein deneddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within trophectodermal cell proliferation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 2
Names
COP9 (constitutive photomorphogenic) homolog, subunit 2
JAB1-containing signalosome subunit 2
SGN2
TR-interacting protein 15
TRIP-15
alien homolog
signalosome subunit 2
thyroid receptor-interacting protein 15
tyroid receptor interacting protein 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429755.1 → NP_001416684.1  COP9 signalosome complex subunit 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003

  2. NM_153297.2 → NP_695209.1  COP9 signalosome complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_695209.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    P61203, Q6P731
    UniProtKB/TrEMBL
    A6HPX8
    Conserved Domains (2) summary
    COG5159
    Location:40 → 434
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:309 → 413
    PCI; PCI domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    133537729..133563493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006234901.5 → XP_006234963.1  COP9 signalosome complex subunit 2 isoform X1

    Related
    ENSRNOP00000075473.2, ENSRNOT00000084154.3
    Conserved Domains (2) summary
    COG5159
    Location:40 → 441
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]
    pfam01399
    Location:316 → 420
    PCI; PCI domain

  2. XM_039104395.2 → XP_038960323.1  COP9 signalosome complex subunit 2 isoform X2

    Conserved Domains (1) summary
    COG5159
    Location:40 → 403
    RPN6; 26S proteasome regulatory complex component [Posttranslational modification, protein turnover, chaperones]

  3. XM_063283173.1 → XP_063139243.1  COP9 signalosome complex subunit 2 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P61203.1 GenPept UniProtKB/Swiss-Prot:P61203

Gene LinkOut

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