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Coq4 Coenzyme Q4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 261607, updated on 10-May-2024

Summary

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Official Symbol
Coq4provided by FlyBase
Official Full Name
Coenzyme Q4provided by FlyBase
Primary source
FLYBASE:FBgn0052174
Locus tag
Dmel_CG32174
See related
AllianceGenome:FB:FBgn0052174
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32174; CG3877; Dmel\CG32174
Summary
Predicted to be involved in ubiquinone biosynthetic process. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Human ortholog(s) of this gene implicated in primary coenzyme Q10 deficiency 7. Orthologous to human COQ4 (coenzyme Q4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Coq4 in Genome Data Viewer
Location:
74B5-74C1; 3-45 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17428936..17433621, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17422036..17426721, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene RNA polymerase III subunit G Neighboring gene Golgin, RAB6 interacting Neighboring gene fringe connection Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Personalized Model of COQ2 Nephropathy Rescued by the Wild-Type COQ2 Allele or Dietary Coenzyme Q(10) Supplementation. Zhu JY, et al. J Am Soc Nephrol, 2017 Sep. PMID 28428331, Free PMC Article
  2. In vivo screening reveals interactions between Drosophila Manf and genes involved in the mitochondria and the ubiquinone synthesis pathway. Lindström R, et al. BMC Genet, 2017 Jun 2. PMID 28578657, Free PMC Article
  3. Selection for cold resistance alters gene transcript levels in Drosophila melanogaster. Telonis-Scott M, et al. J Insect Physiol, 2009 Jun. PMID 19232407
  4. Expression-Based Cell Lineage Analysis in Drosophila Through a Course-Based Research Experience for Early Undergraduates. Olson JM, et al. G3 (Bethesda), 2019 Nov 5. PMID 31690598, Free PMC Article
  5. Genome-wide association analysis of oxidative stress resistance in Drosophila melanogaster. Weber AL, et al. PLoS One, 2012. PMID 22496853, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
coenzyme Q4
Names
CG32174-PB
CG32174-PC
CG32174-PD
Coq4-PB
Coq4-PC
Coq4-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    17428936..17433621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259886.1 → NP_001246815.1  coenzyme Q4, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246815.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z065, Q9VVG6
    UniProtKB/TrEMBL
    E3CTI1, M9NDU8
    Conserved Domains (1) summary
    pfam05019
    Location:54 → 265
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

  2. NM_168732.3 → NP_730270.1  coenzyme Q4, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730270.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z065, Q9VVG6
    UniProtKB/TrEMBL
    E3CTI1, M9NDU8
    Related
    FBpp0074989
    Conserved Domains (1) summary
    pfam05019
    Location:54 → 265
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4

  3. NM_140720.5 → NP_648977.3  coenzyme Q4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648977.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B7Z065, Q9VVG6
    UniProtKB/TrEMBL
    E3CTI1, M9NDU8
    Conserved Domains (1) summary
    pfam05019
    Location:54 → 265
    Coq4; Coenzyme Q (ubiquinone) biosynthesis protein Coq4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9NDU8 M9NDU8
Q9VVG6.3 Q9VVG6

Gene LinkOut

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