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RSL1D1 ribosomal L1 domain containing 1 [ Homo sapiens (human) ]

Gene ID: 26156, updated on 11-Apr-2024

Summary

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Official Symbol
RSL1D1provided by HGNC
Official Full Name
ribosomal L1 domain containing 1provided by HGNC
Primary source
HGNC:HGNC:24534
See related
Ensembl:ENSG00000171490 MIM:615874; AllianceGenome:HGNC:24534
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L12; CSIG; PBK1; UTP30
Summary
Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in regulation of apoptotic process and regulation of cellular senescence. Acts upstream of or within regulation of protein localization. Located in chromosome and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 45.7), lymph node (RPKM 20.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11833850..11851542, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11869901..11887593, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11927707..11945399, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10457 Neighboring gene zinc finger CCCH-type containing 7A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10458 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10459 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7209 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:11890813-11891350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11915504-11916004 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11916005-11916505 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11932294-11932479 Neighboring gene breast cancer anti-estrogen resistance 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:11944561-11945760 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:11946068-11946601 Neighboring gene G1 to S phase transition 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7211 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7212 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:12009257-12010194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:12011253-12011753 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 1 Neighboring gene nuclear pore complex interacting protein family member B2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7215 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10462 Neighboring gene TNF receptor superfamily member 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression. Cheng Q, et al. Oncotarget, 2015 Mar 10. PMID 25749381, Free PMC Article
  2. Identification of differentially expressed genes in human trophoblast cells by differential-display RT-PCR. Huch G, et al. Placenta, 1998 Nov. PMID 9859858
  3. RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability. Jin Y, et al. Carcinogenesis, 2023 May 26. PMID 36913375
  4. Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells. Ding L, et al. Exp Cell Res, 2022 Aug 1. PMID 35597299
  5. RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression. Liu X, et al. Cell Death Dis, 2022 Jan 10. PMID 35013134, Free PMC Article

See all (179) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
    Title: RSL1D1 knockdown induces ferroptosis and mediates ferrous iron accumulation in senescent cells by inhibiting FTH1 mRNA stability.
  2. Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells.
    Title: Mutations in DNA binding domain of p53 impede RSL1D1-p53 interaction to escape from degradation in human colorectal cancer cells.
  3. RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression.
    Title: RSL1D1 promotes the progression of colorectal cancer through RAN-mediated autophagy suppression.
  4. Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells.
    Title: Ribosomal L1 domain-containing protein 1 coordinates with HDM2 to negatively regulate p53 in human colorectal Cancer cells.
  5. CSIG enhanced the phosphatase activity of PPM1A and further inhibited TGF-beta signaling.
    Title: The Cellular Senescence-Inhibited Gene Is Essential for PPM1A Myristoylation To Modulate Transforming Growth Factor β Signaling.
  6. The nucleolar protein CSIG is a novel and crucial regulator of the MDM2-p53 pathway. We demonstrate that CSIG translocates from the nucleolus to the nucleoplasm in response to nucleolar stress. Moreover, knockdown of CSIG attenuates the induction of p53 and abrogates G1 phase arrest in response to nucleolar stress
    Title: Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress.
  7. High CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression.
    Title: CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression.
  8. CSIG acts as a novel regulatory component of replicative senescence, which requires PTEN as a mediator and involves in a translational regulatory mechanism.
    Title: CSIG inhibits PTEN translation in replicative senescence.
  9. Our results suggest that PBK1 is involved in the regulation of uPA expression, which might provide a new clue to further understanding the regulation mechanism of uPA expression.
    Title: Identification of a novel nucleus protein involved in the regulation of urokinase in 95D cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of ribosomal L1 domain containing 1 (RSL1D1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC138433, MGC142259, DKFZP564M182

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 5'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in osteoblast differentiation HDA PubMed 
involved_in regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of cellular senescence IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome IDA
Inferred from Direct Assay
more info
  
located_in membrane HDA PubMed 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ribosomal L1 domain-containing protein 1
Names
CATX-11
cellular senescence-inhibited gene protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015659.3 → NP_056474.2  ribosomal L1 domain-containing protein 1

    See identical proteins and their annotated locations for NP_056474.2

    Status: VALIDATED

    Source sequence(s)
    AC010654, BC113699, BI856275
    Consensus CDS
    CCDS10551.1
    UniProtKB/Swiss-Prot
    B4DJ58, D3DUG7, O76021, Q2M1T7, Q6PL22, Q8IWS7, Q8WUZ1, Q9HDA9, Q9Y3Z9
    UniProtKB/TrEMBL
    Q32Q62
    Related
    ENSP00000460871.1, ENST00000571133.6
    Conserved Domains (2) summary
    cd00403
    Location:36 → 263
    Ribosomal_L1; Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds ...
    cl25751
    Location:324 → 462
    DUF4045; Domain of unknown function (DUF4045)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    11833850..11851542 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    11869901..11887593 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O76021.3 GenPept UniProtKB/Swiss-Prot:O76021

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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