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KIF26A kinesin family member 26A [ Homo sapiens (human) ]

Gene ID: 26153, updated on 2-Nov-2024

Summary

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Official Symbol
KIF26Aprovided by HGNC
Official Full Name
kinesin family member 26Aprovided by HGNC
Primary source
HGNC:HGNC:20226
See related
Ensembl:ENSG00000066735 MIM:613231; AllianceGenome:HGNC:20226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDCBM11
Summary
Predicted to enable microtubule binding activity. Involved in cerebral cortex development; regulation of neuron migration; and regulation of neuron projection development. Predicted to be located in cytosol. Implicated in complex cortical dysplasia with other brain malformations. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in fat (RPKM 3.9), spleen (RPKM 2.2) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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See KIF26A in Genome Data Viewer
Location:
14q32.33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (104138587..104180894)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (98375914..98418495)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104604924..104647231)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene asparaginase Neighboring gene microRNA 203a Neighboring gene microRNA 203b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104600835-104601334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104601943-104602516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104602803-104603514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104603515-104604226 Neighboring gene KIF26A divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104614982-104615497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104617559-104618072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104620618-104621118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104621119-104621619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104635187-104635899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104638041-104638754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104645533-104646067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104655181-104656014 Neighboring gene uncharacterized LOC124903393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104688883-104689775 Neighboring gene long intergenic non-protein coding RNA 2691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104703975-104704476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104705328-104706173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104706174-104707018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104736421-104737106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104737107-104737791 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:104745688-104745903

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon. Almannai M, et al. Hum Genet, 2023 Mar. PMID 36564622
  2. Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis. Qian X, et al. Dev Cell, 2022 Oct 24. PMID 36228617, Free PMC Article
  3. KIF26A is an unconventional kinesin and regulates GDNF-Ret signaling in enteric neuronal development. Zhou R, et al. Cell, 2009 Nov 13. PMID 19914172
  4. All kinesin superfamily protein, KIF, genes in mouse and human. Miki H, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416179, Free PMC Article
  5. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
    Title: KIF26A is mutated in the syndrome of congenital hydrocephalus with megacolon.
  2. Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
    Title: Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Cortical dysplasia, complex, with other brain malformations 11
MedGen: C5774270 OMIM: 620156 GeneReviews: Not available
not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22753, KIAA1236, DKFZp434N178

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in enteric nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
  
NOT involved_in microtubule-based movement ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell growth by extracellular stimulus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF26A
Names
KIF26A variant protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015656.2 → NP_056471.1  kinesin-like protein KIF26A

    See identical proteins and their annotated locations for NP_056471.1

    Status: VALIDATED

    Source sequence(s)
    AL359399
    Consensus CDS
    CCDS45171.1
    UniProtKB/Swiss-Prot
    Q8TAZ7, Q96GK3, Q9UFL3, Q9ULI4
    UniProtKB/TrEMBL
    B0I1R4
    Related
    ENSP00000388241.2, ENST00000423312.7
    Conserved Domains (4) summary
    smart00129
    Location:372 → 731
    KISc; Kinesin motor, catalytic domain. ATPase
    COG3416
    Location:1552 → 1673
    COG3416; Uncharacterized protein [Function unknown]
    PRK07764
    Location:844 → 1285
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00106
    Location:371 → 723
    KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    104138587..104180894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536641.3 → XP_011534943.1  kinesin-like protein KIF26A isoform X1

    UniProtKB/TrEMBL
    C9JFF0
    Conserved Domains (4) summary
    smart00129
    Location:63 → 422
    KISc; Kinesin motor, catalytic domain. ATPase
    COG3416
    Location:1243 → 1364
    COG3416; Uncharacterized protein [Function unknown]
    PRK07764
    Location:535 → 969
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00106
    Location:62 → 414
    KISc; Kinesin motor domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    98375914..98418495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375846.1 → XP_054231821.1  kinesin-like protein KIF26A isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULI4.3 GenPept UniProtKB/Swiss-Prot:Q9ULI4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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