U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TES testin LIM domain protein [ Homo sapiens (human) ]

Gene ID: 26136, updated on 7-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
TESprovided by HGNC
Official Full Name
testin LIM domain proteinprovided by HGNC
Primary source
HGNC:HGNC:14620
See related
Ensembl:ENSG00000135269 MIM:606085; AllianceGenome:HGNC:14620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TESS; TESS-2
Summary
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023]
Expression
Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TES in Genome Data Viewer
Location:
7q31.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116210539..116258783)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (117525529..117573770)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (115850593..115898837)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724407 Neighboring gene VISTA enhancer hs1798 Neighboring gene transcription factor EC Neighboring gene Sharpr-MPRA regulatory region 6568 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:115807196-115807710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115825203-115826194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115826195-115827184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18555 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:115850475-115850737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26529 Neighboring gene uncharacterized LOC124901730 Neighboring gene uncharacterized LOC102724434 Neighboring gene uncharacterized LOC105375463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26531 Neighboring gene Sharpr-MPRA regulatory region 1934 Neighboring gene uncharacterized LOC124900233

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis. Wang DD, et al. Cancer Commun (Lond), 2019 Feb 6. PMID 30728082, Free PMC Article
  2. The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions. Sala S, et al. PLoS One, 2017. PMID 28542564, Free PMC Article
  3. Testin is a tumor suppressor in non-small cell lung cancer. Wang M, et al. Oncol Rep, 2017 Feb. PMID 28000866
  4. TES inhibits colorectal cancer progression through activation of p38. Li H, et al. Oncotarget, 2016 Jul 19. PMID 27323777, Free PMC Article
  5. TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells. Weeks RJ, et al. PLoS One, 2016. PMID 26985820, Free PMC Article

See all (100) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.
    Title: Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.
  2. Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
    Title: Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
  3. Expression of testin is downregulated in the hearts of patients with dilated cardiomyopathy.
    Title: Testin protects against cardiac hypertrophy by targeting a calcineurin-dependent signalling pathway.
  4. TES-mediated upregulation of the transcription factor DDIT3 is involved in CFP suppression of breast cancer cell growth
    Title: CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.
  5. These findings provide a better understanding of the development and progression of gastric cancer (GC) and indicate that TES may be used as a potential prognostic marker and therapeutic target for GC patients.
    Title: TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.
  6. Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
    Title: Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
  7. validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes
    Title: Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.
  8. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways.
    Title: TES inhibits colorectal cancer progression through activation of p38.
  9. testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains
    Title: The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions.
  10. Testin plays an important role in the development and progression of non-small cell lung cancer. Testin is a tumor suppressor.
    Title: Testin is a tumor suppressor in non-small cell lung cancer.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC1146, DKFZp586B2022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion HDA PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in nucleus HDA PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
testin
Names
testis derived transcript (3 LIM domains)

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015641.4 → NP_056456.1  testin isoform 1

    See identical proteins and their annotated locations for NP_056456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.
    Source sequence(s)
    AF245356, DC341259
    Consensus CDS
    CCDS5763.1
    UniProtKB/Swiss-Prot
    A4D0U6, Q9GZQ1, Q9HAJ9, Q9UGI8
    UniProtKB/TrEMBL
    A4D0U5, B2RDR4
    Related
    ENSP00000350937.4, ENST00000358204.9
    Conserved Domains (4) summary
    cd09413
    Location:236 → 293
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:299 → 354
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:361 → 419
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:109 → 196
    PET_testin; The PET domain of Testin

  2. NM_152829.3 → NP_690042.1  testin isoform 2

    See identical proteins and their annotated locations for NP_690042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Thus isoform 2 is nine amino acids shorter than isoform 1.
    Source sequence(s)
    AF245357, AK310995
    Consensus CDS
    CCDS5764.1
    UniProtKB/TrEMBL
    B2RDR4
    Related
    ENSP00000377121.2, ENST00000393481.6
    Conserved Domains (4) summary
    cd09413
    Location:227 → 284
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:290 → 345
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:352 → 410
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:100 → 187
    PET_testin; The PET domain of Testin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    116210539..116258783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    117525529..117573770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGI8.1 GenPept UniProtKB/Swiss-Prot:Q9UGI8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous