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ARHGEF26 Rho guanine nucleotide exchange factor 26 [ Homo sapiens (human) ]

Gene ID: 26084, updated on 3-Apr-2024

Summary

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Official Symbol
ARHGEF26provided by HGNC
Official Full Name
Rho guanine nucleotide exchange factor 26provided by HGNC
Primary source
HGNC:HGNC:24490
See related
Ensembl:ENSG00000114790 MIM:617552; AllianceGenome:HGNC:24490
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SGEF; CSGEF; HMFN1864
Summary
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Expression
Broad expression in lung (RPKM 13.8), brain (RPKM 7.6) and 23 other tissues See more
Orthologs
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Genomic context

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See ARHGEF26 in Genome Data Viewer
Location:
3q25.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (154121003..154257825)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (156892016..157032100)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (153838792..153975614)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene U8 small nucleolar RNA Neighboring gene ARHGEF26 antisense RNA 1 Neighboring gene ribosomal protein L21 pseudogene 42 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_65370 Neighboring gene uncharacterized LOC105374167 Neighboring gene MPRA-validated peak4869 silencer Neighboring gene DEAH-box helicase 36 Neighboring gene Sharpr-MPRA regulatory region 7914 Neighboring gene small nucleolar RNA U13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. Bourgeois JS, et al. PLoS Pathog, 2021 Jul. PMID 34242364, Free PMC Article
  2. SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide. Ensign SP, et al. Mol Cancer Res, 2016 Mar. PMID 26764186, Free PMC Article
  3. SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. Wang H, et al. Oncol Rep, 2012 Oct. PMID 22824926
  4. Comparative proteomic analysis of advanced serous epithelial ovarian carcinoma: possible predictors of chemoresistant disease. Kim SW, et al. OMICS, 2011 May. PMID 21332407
  5. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. Ellerbroek SM, et al. Mol Biol Cell, 2004 Jul. PMID 15133129, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
    Title: Endothelial ARHGEF26 is an angiogenic factor promoting VEGF signalling.
  2. ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.
    Title: ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice.
  3. SGEF plays a role in activating RhoG during invadopodia disassembly
    Title: A RhoG-mediated signaling pathway that modulates invadopodia dynamics in breast cancer cells.
  4. High SGEF expression is associated with lung adenocarcinoma.
    Title: SGEF is a potential prognostic and therapeutic target for lung adenocarcinoma.
  5. Phenome-wide association scanning showed that CCDC92 likely affects coronary artery disease through insulin resistance pathways, whereas experimental analysis suggests that ARHGEF26 influences the transendothelial migration of leukocytes.
    Title: Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease.
  6. yrosine phosphorylation of SGEF suppresses its interaction with RhoG, the elevation of RhoG activity, and SGEF-mediated promotion of cell migration. We identified tyrosine 530 (Y530), which is located within the Dbl homology domain, as a major phosphorylation site of SGEF by Src, and Y530F mutation blocked the inhibitory effect of Src on SGEF
    Title: Tyrosine Phosphorylation of SGEF Regulates RhoG Activity and Cell Migration.
  7. Data support evidence for SGEF role in both the promotion of cell invasion and cell survival signaling within glioblastoma tumors and promoting chemotherapeutic resistance.
    Title: SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival by Modulation of the DNA Repair Response to Temozolomide.
  8. A novel function of SGEF that excludes GEF.
    Title: Grb2 interacts with SGEF and antagonizes the ability of SGEF to enhance EGF-induced ERK1/2 activation.
  9. We report for the first time an SGEF function for RhoG that excludes GEF and the ability of SGEF to enhance EGFR stability and signaling by delaying its lysosomal sorting and degradation
    Title: SGEF enhances EGFR stability through delayed EGFR trafficking from early to late endosomes.
  10. Data indicate that the Src homology 3 domain-containing GEF (SGEF) promotes fibroblast growth factor-inducible 14 (Fn14) proinvasive signaling in glioblastoma via TNF receptor-associated factor 2 (TRAF2).
    Title: The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434D146

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endothelial cell morphogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in ruffle assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in ruffle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 26
Names
Rho guanine nucleotide exchange factor (GEF) 26
SH3 domain-containing guanine exchange factor
Src homology 3 domain-containing guanine nucleotide exchange factor
testicular tissue protein Li 171

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030405.1 RefSeqGene

    Range
    5388..141823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251962.2 → NP_001238891.1  rho guanine nucleotide exchange factor 26 isoform 1

    See identical proteins and their annotated locations for NP_001238891.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC018452, AK127282, AY552599
    Consensus CDS
    CCDS46938.1
    UniProtKB/Swiss-Prot
    B3KVP8, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q96DR7, Q9H9D7, Q9H9R2, Q9UFW5
    UniProtKB/TrEMBL
    A0A140VJU4, B3KXG0
    Related
    ENSP00000348828.4, ENST00000356448.8
    Conserved Domains (3) summary
    cd11938
    Location:793 → 847
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:643 → 781
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443 → 622
    RhoGEF; RhoGEF domain

  2. NM_001251963.2 → NP_001238892.1  rho guanine nucleotide exchange factor 26 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC018452, AK123040, DB069290
    Consensus CDS
    CCDS58858.1
    UniProtKB/TrEMBL
    B3KXG0
    Related
    ENSP00000424446.1, ENST00000496710.5
    Conserved Domains (2) summary
    cd01221
    Location:643 → 781
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443 → 622
    RhoGEF; RhoGEF domain

  3. NM_015595.4 → NP_056410.3  rho guanine nucleotide exchange factor 26 isoform 1

    See identical proteins and their annotated locations for NP_056410.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC018452, AY552599, DA248533, DB069290
    Consensus CDS
    CCDS46938.1
    UniProtKB/Swiss-Prot
    B3KVP8, E9PBD0, Q68CL1, Q6AZ96, Q6Q8Q8, Q96AW8, Q96DR6, Q96DR7, Q9H9D7, Q9H9R2, Q9UFW5
    UniProtKB/TrEMBL
    A0A140VJU4, B3KXG0
    Related
    ENSP00000423418.1, ENST00000465093.6
    Conserved Domains (3) summary
    cd11938
    Location:793 → 847
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:643 → 781
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443 → 622
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    154121003..154257825
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512672.2 → XP_011510974.1  rho guanine nucleotide exchange factor 26 isoform X1

    See identical proteins and their annotated locations for XP_011510974.1

    UniProtKB/TrEMBL
    B3KXG0
    Conserved Domains (3) summary
    cd11938
    Location:763 → 817
    SH3_ARHGEF16_26; Src homology 3 domain of the Rho guanine nucleotide exchange factors ARHGEF16 and ARHGEF26
    cd01221
    Location:615 → 751
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
    pfam00621
    Location:443 → 615
    RhoGEF; RhoGEF domain

  2. XM_047447954.1 → XP_047303910.1  rho guanine nucleotide exchange factor 26 isoform X2

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187533.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    24218..164217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054328656.1 → XP_054184631.1  rho guanine nucleotide exchange factor 26 isoform X2

  2. XM_054328655.1 → XP_054184630.1  rho guanine nucleotide exchange factor 26 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    156892016..157032100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346146.1 → XP_054202121.1  rho guanine nucleotide exchange factor 26 isoform X1

  2. XM_054346147.1 → XP_054202122.1  rho guanine nucleotide exchange factor 26 isoform X2

  3. XM_054346148.1 → XP_054202123.1  rho guanine nucleotide exchange factor 26 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96DR7.4 GenPept UniProtKB/Swiss-Prot:Q96DR7

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