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PRSS33 serine protease 33 [ Homo sapiens (human) ]

Gene ID: 260429, updated on 5-Mar-2024

Summary

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Official Symbol
PRSS33provided by HGNC
Official Full Name
serine protease 33provided by HGNC
Primary source
HGNC:HGNC:30405
See related
Ensembl:ENSG00000103355 MIM:613797; AllianceGenome:HGNC:30405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EOS
Summary
Enables serine-type endopeptidase activity. Involved in protein kinase C signaling and proteolysis. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2783953..2787915, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2804168..2808494, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2833954..2837916, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:2801519-2802361 and GRCh37_chr16:2802362-2803204 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2803205-2804047 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:2807529-2808728 Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2819013-2819715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2819716-2820419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2820420-2821122 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2823070-2823222 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7073 Neighboring gene elongin B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10283 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2828259-2829193 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2829194-2830127 Neighboring gene small nucleolar RNA, H/ACA box 3C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2852262-2853224 Neighboring gene serine protease 41

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human eosinophils constitutively express a unique serine protease, PRSS33. Toyama S, et al. Allergol Int, 2017 Jul. PMID 28216055
  2. A novel serine protease predominately expressed in macrophages. Chen C, et al. Biochem J, 2003 Aug 15. PMID 12795636, Free PMC Article
  3. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. Oláh J, et al. J Biol Chem, 2011 Sep 30. PMID 21832049, Free PMC Article
  4. Architecture of the human interactome defines protein communities and disease networks. Huttlin EL, et al. Nature, 2017 May 25. PMID 28514442, Free PMC Article
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein kinase C signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine protease 33
Names
protease, serine 33
serine protease EOS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385462.1 → NP_001372391.1  serine protease 33 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    A6NNQ3, Q8N171, Q8NF86
    Conserved Domains (1) summary
    cd00190
    Location:37 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_001385463.1 → NP_001372392.1  serine protease 33 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    A6NNQ3, Q8N171, Q8NF86
    Conserved Domains (1) summary
    cd00190
    Location:37 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  3. NM_001385464.1 → NP_001372393.1  serine protease 33 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    A6NNQ3, Q8N171, Q8NF86
    Related
    ENSP00000458369.1, ENST00000570702.5
    Conserved Domains (1) summary
    cd00190
    Location:37 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  4. NM_152891.3 → NP_690851.2  serine protease 33 precursor

    See identical proteins and their annotated locations for NP_690851.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    A6NNQ3, Q8N171, Q8NF86
    Related
    ENSP00000507560.1, ENST00000682474.1
    Conserved Domains (1) summary
    cd00190
    Location:37 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_169625.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092117

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2783953..2787915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2804168..2808494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NF86.3 GenPept UniProtKB/Swiss-Prot:Q8NF86

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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