tp63 tumor protein p63 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tp63provided by ZNC
Official Full Name: tumor protein p63provided by ZNC
Primary source: ZFIN:ZDB-GENE-030819-1
See related: Ensembl:ENSDARG00000044356 AllianceGenome:ZFIN:ZDB-GENE-030819-1
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: p63; DNp63; tp73l; fc89f04; id:ibd3516; wu:fc89f04; wu:fk85h07; wu:fk88b02
Summary: Enables DNA binding activity. Involved in regulation of ectodermal cell fate specification. Acts upstream of or within several processes, including epidermis morphogenesis; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of programmed necrotic cell death. Located in nucleus. Is expressed in several structures, including brain; digestive system; ectoderm; gonad; and integument. Human ortholog(s) of this gene implicated in several diseases, including ADULT syndrome; EEC syndrome (multiple); ectodermal dysplasia (multiple); orofacial cleft 8; and split hand-foot malformation 4. Orthologous to human TP63 (tumor protein p63). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (28795710..28914225)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (28886745..28923664)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis.
Title: Puma, noxa, p53, and p63 differentially mediate stress pathway induced apoptosis.
During early zebrafish embryonic development, p63 binds to enhancers associated to neural plate-expressing genes, where it limits Sox3 binding and neural gene expression. p63 binds enhancers associated to epidermis-expressing genes when they are in a non-accessible chromatin state, leading to its opening and epidermal gene expression.
Title: Pioneer and repressive functions of p63 during zebrafish embryonic ectoderm specification.
they unravel essential roles of TAp63 and p53 to promote both keratinocyte proliferation and their terminal differentiation by promoting Notch signalling and caspase 3 activity.
Title: p53 and TAp63 promote keratinocyte proliferation and differentiation in breeding tubercles of the zebrafish.
the p63 transcription factor is upregulated to initiate this apoptotic pathway and directly activates puma transcription in response to ER stress.
Title: p63 mediates an apoptotic response to pharmacological and disease-related ER stress in the developing epidermis.
rps19-deficient phenotype is mediated by dysregulation of deltaNp63 and p53 and results in hematopoietic and developmental abnormalities resembling Diamond-Blackfan anemia
Title: Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family.
DeltaNp63 expression blocks neural development and promotes nonneural development, even in the absence of Bmp signaling. (DeltaNp63)
Title: Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm.
Early zebrafish embryos express a dominant-negative form of p63 (DeltaNp63), which accumulates in the nucleus just as epidermal growth begins. (p63)
Title: A dominant-negative form of p63 is required for epidermal proliferation in zebrafish.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fl03c02.x1 (e-PCR)
- UniSTS:201866

fk85h07.x1 (e-PCR)
- UniSTS:201637

fc89f04.x1 (e-PCR)
- UniSTS:188371

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within central nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epidermis morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein tetramerization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of ectodermal cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tumor protein 63

Names: TP63 TA; delta-Np63

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_152248.2 → NP_689454.1 tumor protein 63 isoform alpha 2

See identical proteins and their annotated locations for NP_689454.1

Status: VALIDATED

Source sequence(s)

BX004773, BX004878

UniProtKB/TrEMBL

F6P6M9, Q78BD0, Q8JFE3, Q8JHZ6

Related

ENSDARP00000107767.1, ENSDART00000130799.2

Conserved Domains (4) summary

cd09572
Location:437 → 501

SAM_tumor-p63; SAM domain of tumor-p63 proteins

smart00454
Location:441 → 501

SAM; Sterile alpha motif

pfam00870
Location:67 → 262

P53; P53 DNA-binding domain

pfam07710
Location:292 → 332

P53_tetramer; P53 tetramerization motif
NM_152986.2 → NP_694518.2 tumor protein 63 isoform alpha 1

Status: VALIDATED

Source sequence(s)

BX004773, BX004878

Related

ENSDARP00000065136.1, ENSDART00000065137.3

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

28795710..28914225

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_068221641.1 → XP_068077742.1 tumor protein 63 isoform X5

Related

ENSDARP00000108362.2, ENSDART00000127965.4
XM_068221636.1 → XP_068077737.1 tumor protein 63 isoform X1
XM_068221639.1 → XP_068077740.1 tumor protein 63 isoform X3
XM_068221642.1 → XP_068077743.1 tumor protein 63 isoform X6

Related

ENSDARP00000132905.1, ENSDART00000163541.2
XM_068221637.1 → XP_068077738.1 tumor protein 63 isoform X1
XM_068221638.1 → XP_068077739.1 tumor protein 63 isoform X2
XM_068221640.1 → XP_068077741.1 tumor protein 63 isoform X4
XM_068221643.1 → XP_068077744.1 tumor protein 63 isoform X7
XM_068221644.1 → XP_068077745.1 tumor protein 63 isoform X8
XM_068221645.1 → XP_068077746.1 tumor protein 63 isoform X9

Reference GRCz11 ALT_DRER_TU_1

Genomic

NW_018394646.1 Reference GRCz11 ALT_DRER_TU_1

Range

225968..262930

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_152987.1: Suppressed sequence

Description

NM_152987.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.