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SIPA1L1 signal induced proliferation associated 1 like 1 [ Homo sapiens (human) ]

Gene ID: 26037, updated on 3-Apr-2024

Summary

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Official Symbol
SIPA1L1provided by HGNC
Official Full Name
signal induced proliferation associated 1 like 1provided by HGNC
Primary source
HGNC:HGNC:20284
See related
Ensembl:ENSG00000197555 MIM:617504; AllianceGenome:HGNC:20284
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
E6TP1; SPAR1
Summary
Predicted to enable GTPase activator activity; actin filament binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; activation of GTPase activity; and regulation of postsynapse organization. Located in actin cytoskeleton and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 7.9), spleen (RPKM 7.4) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See SIPA1L1 in Genome Data Viewer
Location:
14q24.2
Exon count:
38
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (71320476..71741209)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (65525922..65946692)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (71787193..72207926)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370706 Neighboring gene Sharpr-MPRA regulatory region 2320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8671 Neighboring gene uncharacterized LOC107984654 Neighboring gene Sharpr-MPRA regulatory region 5380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5896 Neighboring gene SIPA1L1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8672 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8673 Neighboring gene PDZ domain containing 11 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8674 Neighboring gene small nucleolar RNA, C/D box 56B Neighboring gene RNA, 7SL, cytoplasmic 683, pseudogene Neighboring gene uncharacterized LOC145474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8675 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8676 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8677 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8679 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72072179-72072936 Neighboring gene uncharacterized LOC124903342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72220712-72221626 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72225004-72225562 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:72240666-72241865 Neighboring gene Sharpr-MPRA regulatory region 15223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72315448-72316027 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72318891-72319392 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8680 Neighboring gene NANOG hESC enhancer GRCh37_chr14:72362092-72362593 Neighboring gene translation initiation factor IF-2-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5899 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5900 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5901 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:72410437-72410648 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:72448203-72448816 Neighboring gene regulator of G protein signaling 6 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:72542545-72543085 Neighboring gene uncharacterized LOC124903343 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr14:72621633-72622832

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle. Lee C, et al. Virology, 2007 Feb 5. PMID 16999984
  2. Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era. Bentley SR, et al. Genes (Basel), 2021 Mar 17. PMID 33802862, Free PMC Article
  3. Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3. Dolnik A, et al. J Neurochem, 2016 Jan. PMID 26364583
  4. RapGAPs in brain: multipurpose players in neuronal Rap signalling. Spilker C, et al. Eur J Neurosci, 2010 Jul. PMID 20576033
  5. The E6 oncoproteins of high-risk papillomaviruses bind to a novel putative GAP protein, E6TP1, and target it for degradation. Gao Q, et al. Mol Cell Biol, 1999 Jan. PMID 9858596, Free PMC Article

See all (74) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.
    Title: Hunting for Familial Parkinson's Disease Mutations in the Post Genome Era.
  2. Sipa1L1 is conserved across species, has a distinct expression pattern in brain and is localized to excitatory postsynapses.
    Title: Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3.
  3. investigated the consequences of human papillomavirus 31 E6 binding to E6TP1; observed that binding & degradation of E6TP1 by HPV type 31 E6 are required to extend life span of keratinocytes & the long-term, stable replication of the viral genome
    Title: Analysis of the roles of E6 binding to E6TP1 and nuclear localization in the human papillomavirus type 31 life cycle.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural Chinese sample.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37213, KIAA0440, DKFZp686G1344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ephrin receptor binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in activation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in ephrin receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of GTPase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of axonogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of dendritic spine morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
signal-induced proliferation-associated 1-like protein 1
Names
SIPA1-like protein 1
high-risk human papilloma viruses E6 oncoproteins targeted protein 1
spine-associated RapGAP 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284245.3 → NP_001271174.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001271174.1

    Status: VALIDATED

    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, DA330003
    Consensus CDS
    CCDS61490.1
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1716 → 1771
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1728
    SPAR_C; C-terminal domain of SPAR protein

  2. NM_001284246.2 → NP_001271175.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001271175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
    Source sequence(s)
    AC004900, AC004974, AF090989, AK122930
    Consensus CDS
    CCDS61491.1
    UniProtKB/TrEMBL
    A6H8W6
    Related
    ENSP00000351352.2, ENST00000358550.6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1715 → 1770
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1727
    SPAR_C; C-terminal domain of SPAR protein

  3. NM_001284247.3 → NP_001271176.1  signal-induced proliferation-associated 1-like protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001271176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AB007900, AC004900, AC004968, AL707661, BM697295, CR936651, DA034212, DA184827, DA265109, DA330003, DT219010
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1736 → 1791
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1504 → 1748
    SPAR_C; C-terminal domain of SPAR protein

  4. NM_001354285.2 → NP_001341214.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Both variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476, AF090990, DA330003
    Consensus CDS
    CCDS9807.1
    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1737 → 1792
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1504 → 1749
    SPAR_C; C-terminal domain of SPAR protein

  5. NM_001354286.2 → NP_001341215.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, AK122930, DA330003
    Consensus CDS
    CCDS61491.1
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1715 → 1770
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1727
    SPAR_C; C-terminal domain of SPAR protein

  6. NM_001354287.2 → NP_001341216.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476, AF090989, AK122930, DA330003
    Consensus CDS
    CCDS61491.1
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1715 → 1770
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1727
    SPAR_C; C-terminal domain of SPAR protein

  7. NM_001354288.2 → NP_001341217.1  signal-induced proliferation-associated 1-like protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks an alternate in-frame exon, uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Variants 3, 6, 7, and 8 encode the same isoform (3).
    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476, AF090989, AK122930, DA330003
    Consensus CDS
    CCDS61491.1
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1715 → 1770
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1727
    SPAR_C; C-terminal domain of SPAR protein

  8. NM_001354289.2 → NP_001341218.1  signal-induced proliferation-associated 1-like protein 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476, AC005994, AF090989, DA330003
    UniProtKB/TrEMBL
    F5GYF8
    Conserved Domains (4) summary
    cd00992
    Location:459 → 529
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:135 → 315
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1221 → 1276
    ZapB; Cell division protein ZapB
    pfam11881
    Location:989 → 1233
    SPAR_C; C-terminal domain of SPAR protein

  9. NM_001386936.1 → NP_001373865.1  signal-induced proliferation-associated 1-like protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476
    Consensus CDS
    CCDS61490.1
    UniProtKB/TrEMBL
    A6H8W6
    Related
    ENSP00000370630.3, ENST00000381232.8
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1716 → 1771
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1483 → 1728
    SPAR_C; C-terminal domain of SPAR protein

  10. NM_015556.4 → NP_056371.1  signal-induced proliferation-associated 1-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_056371.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AC004900, AC004968, AC004974, AC005476, AC005994, AF090990, DA330003
    Consensus CDS
    CCDS9807.1
    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1737 → 1792
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1504 → 1749
    SPAR_C; C-terminal domain of SPAR protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    71320476..71741209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431217.1 → XP_047287173.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  2. XM_047431229.1 → XP_047287185.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  3. XM_047431218.1 → XP_047287174.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  4. XM_047431243.1 → XP_047287199.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  5. XM_047431251.1 → XP_047287207.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  6. XM_047431209.1 → XP_047287165.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  7. XM_047431239.1 → XP_047287195.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  8. XM_047431245.1 → XP_047287201.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  9. XM_047431253.1 → XP_047287209.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

  10. XM_047431219.1 → XP_047287175.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  11. XM_047431238.1 → XP_047287194.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  12. XM_047431247.1 → XP_047287203.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  13. XM_047431246.1 → XP_047287202.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  14. XM_024449529.2 → XP_024305297.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1737 → 1792
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1504 → 1749
    SPAR_C; C-terminal domain of SPAR protein

  15. XM_017021198.2 → XP_016876687.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

    UniProtKB/TrEMBL
    F5GYF8

  16. XM_047431249.1 → XP_047287205.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  17. XM_047431252.1 → XP_047287208.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

  18. XM_047431223.1 → XP_047287179.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  19. XM_047431248.1 → XP_047287204.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  20. XM_047431241.1 → XP_047287197.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  21. XM_011536632.2 → XP_011534934.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011534934.1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1737 → 1792
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1504 → 1749
    SPAR_C; C-terminal domain of SPAR protein

  22. XM_047431250.1 → XP_047287206.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  23. XM_047431220.1 → XP_047287176.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  24. XM_047431224.1 → XP_047287180.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  25. XM_047431242.1 → XP_047287198.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  26. XM_047431231.1 → XP_047287187.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  27. XM_047431227.1 → XP_047287183.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  28. XM_047431215.1 → XP_047287171.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  29. XM_047431240.1 → XP_047287196.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  30. XM_047431213.1 → XP_047287169.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  31. XM_047431214.1 → XP_047287170.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  32. XM_047431212.1 → XP_047287168.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  33. XM_047431226.1 → XP_047287182.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  34. XM_047431211.1 → XP_047287167.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  35. XM_047431222.1 → XP_047287178.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  36. XM_047431244.1 → XP_047287200.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  37. XM_047431232.1 → XP_047287188.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

  38. XM_047431233.1 → XP_047287189.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

  39. XM_047431234.1 → XP_047287190.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

  40. XM_047431235.1 → XP_047287191.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

  41. XM_047431236.1 → XP_047287192.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

  42. XM_047431237.1 → XP_047287193.1  signal-induced proliferation-associated 1-like protein 1 isoform X7

  43. XM_047431228.1 → XP_047287184.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  44. XM_047431225.1 → XP_047287181.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  45. XM_047431216.1 → XP_047287172.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  46. XM_005267516.5 → XP_005267573.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005267573.1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4
    UniProtKB/TrEMBL
    A6H8W6
    Related
    ENSP00000450832.1, ENST00000555818.5
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1737 → 1792
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1504 → 1749
    SPAR_C; C-terminal domain of SPAR protein

  47. XM_017021185.2 → XP_016876674.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

    UniProtKB/TrEMBL
    A6H8W6
    Conserved Domains (4) summary
    cd00992
    Location:953 → 1023
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:629 → 809
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1736 → 1791
    ZapB; Cell division protein ZapB
    pfam11881
    Location:1504 → 1748
    SPAR_C; C-terminal domain of SPAR protein

  48. XM_011536638.3 → XP_011534940.1  signal-induced proliferation-associated 1-like protein 1 isoform X11

    UniProtKB/TrEMBL
    F5GYF8
    Related
    ENSP00000440682.1, ENST00000537413.5
    Conserved Domains (4) summary
    cd00992
    Location:428 → 498
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam02145
    Location:104 → 284
    Rap_GAP; Rap/ran-GAP
    pfam06005
    Location:1212 → 1267
    DUF904; Protein of unknown function (DUF904)
    pfam11881
    Location:979 → 1224
    SPAR_C; C-terminal domain of SPAR protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    65525922..65946692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375796.1 → XP_054231771.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  2. XM_054375805.1 → XP_054231780.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  3. XM_054375797.1 → XP_054231772.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  4. XM_054375795.1 → XP_054231770.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  5. XM_054375802.1 → XP_054231777.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  6. XM_054375803.1 → XP_054231778.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  7. XM_054375794.1 → XP_054231769.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  8. XM_054375801.1 → XP_054231776.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  9. XM_054375825.1 → XP_054231800.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  10. XM_054375791.1 → XP_054231766.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  11. XM_054375811.1 → XP_054231786.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

  12. XM_054375813.1 → XP_054231788.1  signal-induced proliferation-associated 1-like protein 1 isoform X3

  13. XM_054375814.1 → XP_054231789.1  signal-induced proliferation-associated 1-like protein 1 isoform X4

  14. XM_054375815.1 → XP_054231790.1  signal-induced proliferation-associated 1-like protein 1 isoform X5

  15. XM_054375816.1 → XP_054231791.1  signal-induced proliferation-associated 1-like protein 1 isoform X6

  16. XM_054375817.1 → XP_054231792.1  signal-induced proliferation-associated 1-like protein 1 isoform X7

  17. XM_054375808.1 → XP_054231783.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  18. XM_054375804.1 → XP_054231779.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  19. XM_054375809.1 → XP_054231784.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  20. XM_054375823.1 → XP_054231798.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  21. XM_054375833.1 → XP_054231808.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  22. XM_054375793.1 → XP_054231768.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  23. XM_054375820.1 → XP_054231795.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  24. XM_054375826.1 → XP_054231801.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  25. XM_054375835.1 → XP_054231810.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

  26. XM_054375798.1 → XP_054231773.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  27. XM_054375819.1 → XP_054231794.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  28. XM_054375828.1 → XP_054231803.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  29. XM_054375827.1 → XP_054231802.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  30. XM_054375807.1 → XP_054231782.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  31. XM_054375818.1 → XP_054231793.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  32. XM_054375830.1 → XP_054231805.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  33. XM_054375834.1 → XP_054231809.1  signal-induced proliferation-associated 1-like protein 1 isoform X10

  34. XM_054375821.1 → XP_054231796.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  35. XM_054375799.1 → XP_054231774.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  36. XM_054375800.1 → XP_054231775.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  37. XM_054375810.1 → XP_054231785.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  38. XM_054375829.1 → XP_054231804.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  39. XM_054375832.1 → XP_054231807.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  40. XM_054375822.1 → XP_054231797.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  41. XM_054375824.1 → XP_054231799.1  signal-induced proliferation-associated 1-like protein 1 isoform X8

  42. XM_054375831.1 → XP_054231806.1  signal-induced proliferation-associated 1-like protein 1 isoform X9

  43. XM_054375806.1 → XP_054231781.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  44. XM_054375792.1 → XP_054231767.1  signal-induced proliferation-associated 1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    J3KP19, O43166, O95321, Q9UDU4, Q9UNU4

  45. XM_054375812.1 → XP_054231787.1  signal-induced proliferation-associated 1-like protein 1 isoform X2

  46. XM_054375836.1 → XP_054231811.1  signal-induced proliferation-associated 1-like protein 1 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43166.4 GenPept UniProtKB/Swiss-Prot:O43166

Gene LinkOut

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