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ZNF451 zinc finger protein 451 [ Homo sapiens (human) ]

Gene ID: 26036, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF451provided by HGNC
Official Full Name
zinc finger protein 451provided by HGNC
Primary source
HGNC:HGNC:21091
See related
Ensembl:ENSG00000112200 MIM:615708; AllianceGenome:HGNC:21091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZATT; COASTER; dJ417I1.1
Summary
Enables SUMO ligase activity and transcription corepressor activity. Involved in negative regulation of nitrogen compound metabolic process; negative regulation of transforming growth factor beta receptor signaling pathway; and protein sumoylation. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 8.1), testis (RPKM 5.2) and 24 other tissues See more
Orthologs
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Genomic context

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See ZNF451 in Genome Data Viewer
Location:
6p12.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (57090188..57170305)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (56929190..57009330)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (56954986..57035103)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:56895065-56895565 Neighboring gene Sharpr-MPRA regulatory region 7771 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56912079-56912956 Neighboring gene mitochondrial ribosomal protein L30 pseudogene 1 Neighboring gene KIAA1586 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:56954672-56955554 Neighboring gene ZNF451 regulatory antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:57037271-57038028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17304 Neighboring gene BAG cochaperone 2 Neighboring gene RAB23, member RAS oncogene family Neighboring gene DNA primase subunit 2 Neighboring gene long intergenic non-protein coding RNA 3001

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Stress-induced nuclear condensation of NELF drives transcriptional downregulation. Rawat P, et al. Mol Cell, 2021 Mar 4. PMID 33548202, Free PMC Article
  2. LncRNA BC032020 suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451. Zhang Z, et al. Int J Oncol, 2018 Apr. PMID 29532883, Free PMC Article
  3. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links. Schellenberg MJ, et al. Science, 2017 Sep 29. PMID 28912134, Free PMC Article
  4. A new vertebrate SUMO enzyme family reveals insights into SUMO-chain assembly. Eisenhardt N, et al. Nat Struct Mol Biol, 2015 Dec. PMID 26524493
  5. Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1. Gao J, et al. J Exp Clin Cancer Res, 2022 Oct 8. PMID 36209117, Free PMC Article

See all (66) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression.
    Title: ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression.
  2. Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1.
    Title: Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1.
  3. Stress-induced nuclear condensation of NELF drives transcriptional downregulation.
    Title: Stress-induced nuclear condensation of NELF drives transcriptional downregulation.
  4. The findings of this study indicate that BC032020 suppresses the survival of PDAC cells by inhibiting ZNF451 expression.
    Title: LncRNA BC032020 suppresses the survival of human pancreatic ductal adenocarcinoma cells by targeting ZNF451.
  5. These findings uncover a ZNF451-TDP2-catalyzed and SUMO2-modulated pathway for direct resolution of TOP2 cleavage complex.
    Title: ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
  6. The authors show that ZNF451 is SUMO2 specific and that SUMO modification of ZNF451 may contribute to activity by providing a second molecule of SUMO that interacts with E2.
    Title: Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase.
  7. ZNF451 acts as a transcriptional corepressor for Smad3/4 and negatively regulates TGF-beta signaling.
    Title: Zinc finger protein 451 is a novel Smad corepressor in transforming growth factor-β signaling.
  8. Data describe ZNF451, a nuclear protein that can be associated with promyelocytic leukemia bodies, and exerts its effects via SUMO modification machinery and trafficking of transcription regulators between promyelocytic leukemia bodies and nucleoplasm.
    Title: ZNF451 is a novel PML body- and SUMO-associated transcriptional coregulator.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23421, FLJ53246, FLJ90693, KIAA0576, KIAA1702, MGC26701

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables transcription regulator inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription initiation by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription initiation by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in PML body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
E3 SUMO-protein ligase ZNF451
Names
E3 SUMO-protein transferase ZNF451
coactivator for steroid receptors
zinc finger protein associated with TDP2 and TOP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031623.3 → NP_001026794.1  E3 SUMO-protein ligase ZNF451 isoform 1

    See identical proteins and their annotated locations for NP_001026794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AB011148, AK027805, AL136311, AY055204, CN314846
    Consensus CDS
    CCDS43477.1
    UniProtKB/Swiss-Prot
    Q5VVE9, Q5VVF1, Q86YE4, Q8N380, Q8TD15, Q9C0G1, Q9NQM1, Q9Y4E5
    UniProtKB/TrEMBL
    E9PH99
    Related
    ENSP00000359740.4, ENST00000370706.9

  2. NM_001257273.2 → NP_001244202.1  E3 SUMO-protein ligase ZNF451 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and its transcription extends past a splice site that is used in variant 1, resulting in a novel 3' coding region and 3' UTR compared to variant 1. It encodes isoform 3 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK302577, AL450489, CK301064
    Consensus CDS
    CCDS59026.1
    UniProtKB/TrEMBL
    B4DYS2
    Related
    ENSP00000359742.4, ENST00000370708.8
    Conserved Domains (1) summary
    pfam11560
    Location:358 → 498
    LAP2alpha; Lamina-associated polypeptide 2 alpha

  3. NM_015555.3 → NP_056370.2  E3 SUMO-protein ligase ZNF451 isoform 2

    See identical proteins and their annotated locations for NP_056370.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 5' coding region, compared to variant 1. Isoform 2 is shorter, compared to isoform 1.
    Source sequence(s)
    AA336048, AL136311, AY055204, BM559241, CN314846
    Consensus CDS
    CCDS4960.1
    UniProtKB/TrEMBL
    E9PH99
    Related
    ENSP00000350083.3, ENST00000357489.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    57090188..57170305
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011514460.3 → XP_011512762.1  E3 SUMO-protein ligase ZNF451 isoform X1

    UniProtKB/TrEMBL
    E9PH99

  2. XM_047418624.1 → XP_047274580.1  E3 SUMO-protein ligase ZNF451 isoform X3

  3. XM_011514462.4 → XP_011512764.1  E3 SUMO-protein ligase ZNF451 isoform X4

    UniProtKB/TrEMBL
    E9PH99
    Related
    ENST00000444273.6

  4. XM_011514463.3 → XP_011512765.1  E3 SUMO-protein ligase ZNF451 isoform X5

    Conserved Domains (1) summary
    pfam11560
    Location:330 → 470
    LAP2alpha; Lamina-associated polypeptide 2 alpha

  5. XM_011514461.3 → XP_011512763.1  E3 SUMO-protein ligase ZNF451 isoform X2

    UniProtKB/TrEMBL
    E9PH99

RNA

  1. XR_007059234.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    56929190..57009330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054355130.1 → XP_054211105.1  E3 SUMO-protein ligase ZNF451 isoform X1

  2. XM_054355132.1 → XP_054211107.1  E3 SUMO-protein ligase ZNF451 isoform X3

  3. XM_054355133.1 → XP_054211108.1  E3 SUMO-protein ligase ZNF451 isoform X4

  4. XM_054355134.1 → XP_054211109.1  E3 SUMO-protein ligase ZNF451 isoform X5

  5. XM_054355131.1 → XP_054211106.1  E3 SUMO-protein ligase ZNF451 isoform X2

RNA

  1. XR_008487294.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y4E5.2 GenPept UniProtKB/Swiss-Prot:Q9Y4E5

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