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TUBB8B tubulin beta 8B [ Homo sapiens (human) ]

Gene ID: 260334, updated on 5-Mar-2024

Summary

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Official Symbol
TUBB8Bprovided by HGNC
Official Full Name
tubulin beta 8Bprovided by HGNC
Primary source
HGNC:HGNC:24983
See related
Ensembl:ENSG00000173213 AllianceGenome:HGNC:24983
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUBB8P12
Summary
Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
18p11.32
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (47212..73539, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (201006..227325, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47221..73539, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904234 Neighboring gene long intergenic non-protein coding RNA 2564 Neighboring gene uncharacterized LOC105371950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:78692-79192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:79193-79693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:81490-82403 Neighboring gene IL9R pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 10972 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr18:106915-107598 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:107891-108680 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:108681-109468 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:109469-110257 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr18:110258-111045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9235 Neighboring gene Rho associated coiled-coil containing protein kinase 1 pseudogene 1 Neighboring gene microRNA 8078

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A cascade of complex subtelomeric duplications during the evolution of the hominoid and Old World monkey genomes. van Geel M, et al. Am J Hum Genet, 2002 Jan. PMID 11731935, Free PMC Article
  2. CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer. Liu Y, et al. Cell Death Dis, 2019 Sep 9. PMID 31501420, Free PMC Article
  3. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Faust TB, et al. Elife, 2018 May 30. PMID 29845934, Free PMC Article
  4. BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression. Yu L, et al. Genes Dev, 2018 Dec 1. PMID 30463901, Free PMC Article
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
tubulin beta 8B
Names
HSA18p11 beta-tubulin 4Q pseudogene
Tubulin beta-8 chain-like protein LOC260334
tubulin beta 8 pseudogene 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358689.2 → NP_001345618.1  tubulin beta 8B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001005
    Consensus CDS
    CCDS86657.1
    UniProtKB/Swiss-Prot
    A6NNZ2
    UniProtKB/TrEMBL
    A0A183YE00
    Related
    ENSP00000496713.1, ENST00000308911.9
    Conserved Domains (1) summary
    PLN00220
    Location:1 → 427
    PLN00220; tubulin beta chain; Provisional

  2. NM_001389609.1 → NP_001376538.1  tubulin beta 8B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001005
    UniProtKB/TrEMBL
    A0A075B736
    Conserved Domains (1) summary
    PLN00220
    Location:1 → 355
    PLN00220; tubulin beta chain; Provisional

  3. NM_001389610.1 → NP_001376539.1  tubulin beta 8B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001005
    Conserved Domains (1) summary
    cd02187
    Location:112 → 375
    beta_tubulin; The beta-tubulin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    47212..73539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451147.2 → XP_024306915.1  tubulin beta 8B isoform X3

    UniProtKB/TrEMBL
    Q9UGA2
    Conserved Domains (1) summary
    PTZ00010
    Location:1 → 311
    PTZ00010; tubulin beta chain; Provisional

  2. XM_024451143.2 → XP_024306911.1  tubulin beta 8B isoform X1

    Related
    ENST00000706408.1
    Conserved Domains (1) summary
    cd02187
    Location:112 → 375
    beta_tubulin; The beta-tubulin family

  3. XM_024451144.2 → XP_024306912.1  tubulin beta 8B isoform X1

    Conserved Domains (1) summary
    cd02187
    Location:112 → 375
    beta_tubulin; The beta-tubulin family

  4. XM_024451146.2 → XP_024306914.1  tubulin beta 8B isoform X2

    UniProtKB/TrEMBL
    Q5SQY0
    Conserved Domains (1) summary
    cd02187
    Location:13 → 346
    beta_tubulin; The beta-tubulin family

  5. XM_024451148.2 → XP_024306916.1  tubulin beta 8B isoform X4

    UniProtKB/TrEMBL
    Q96B85
    Conserved Domains (1) summary
    cd02187
    Location:10 → 273
    beta_tubulin; The beta-tubulin family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    201006..227325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002339.3: Suppressed sequence

    Description
    NG_002339.3: This RefSeq was removed because it is currently thought that this locus produces a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NNZ2.1 GenPept UniProtKB/Swiss-Prot:A6NNZ2

Gene LinkOut

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Molecular Biology Databases
Research Materials