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Prrt1 proline-rich transmembrane protein 1 [ Mus musculus (house mouse) ]

Gene ID: 260297, updated on 2-Nov-2024

Summary

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Official Symbol
Prrt1provided by MGI
Official Full Name
proline-rich transmembrane protein 1provided by MGI
Primary source
MGI:MGI:1932118
See related
Ensembl:ENSMUSG00000015476 AllianceGenome:MGI:1932118
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G5b; NG5; Bat4; Bat-4; DSPD1; ORF31; SynDIG4; D17H6S54E
Summary
Enables signaling receptor regulator activity. Involved in several processes, including long-term synaptic depression; protein localization to cell surface; and regulation of AMPA receptor activity. Acts upstream of or within several processes, including learning or memory; long-term synaptic potentiation; and synapse organization. Located in synaptic vesicle membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Orthologous to human PRRT1 (proline rich transmembrane protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in thymus adult (RPKM 81.7), cerebellum adult (RPKM 35.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Prrt1 in Genome Data Viewer
Location:
17 B1; 17 18.21 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34848396..34852108)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (34629365..34633134)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 1 Neighboring gene EGF-like domain 8 Neighboring gene palmitoyl-protein thioesterase 2 Neighboring gene RIKEN cDNA 2610029K11 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34767227-34767451 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34768061-34768244 Neighboring gene STARR-positive B cell enhancer ABC_E770 Neighboring gene STARR-positive B cell enhancer ABC_E4212 Neighboring gene FK506 binding protein-like Neighboring gene activating transcription factor 6 beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking. Troyano-Rodriguez E, et al. Mol Cell Neurosci, 2019 Jul. PMID 31216424
  2. Expression and Interaction Proteomics of GluA1- and GluA3-Subunit-Containing AMPARs Reveal Distinct Protein Composition. van der Spek SJF, et al. Cells, 2022 Nov 17. PMID 36429079, Free PMC Article
  3. SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development. Kalashnikova E, et al. Neuron, 2010 Jan 14. PMID 20152115, Free PMC Article
  4. Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo. Chenaux G, et al. eNeuro, 2016 Sep-Oct. PMID 27800545, Free PMC Article
  5. SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function. Matt L, et al. Cell Rep, 2018 Feb 27. PMID 29490264, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRRT1 controls NMDA-induced trafficking of AMPA receptors in hippocampal neurons.
    Title: PRRT1 regulates basal and plasticity-induced AMPA receptor trafficking.
  2. SynDIG4 maintains a pool of extrasynaptic AMPARs necessary for synapse development and function underlying higher-order cognitive plasticity.
    Title: SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables signaling receptor regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within learning or memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term synaptic depression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of AMPA receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of AMPA receptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proline-rich transmembrane protein 1
Names
dispanin subfamily D member 1
synapse differentiation-induced protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368728.1 → NP_001355657.1  proline-rich transmembrane protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CT009767
    Conserved Domains (1) summary
    pfam04505
    Location:217 → 284
    CD225; Interferon-induced transmembrane protein

  2. NM_001368729.1 → NP_001355658.1  proline-rich transmembrane protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CT009767

  3. NM_001368730.1 → NP_001355659.1  proline-rich transmembrane protein 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CT009767

  4. NM_030890.2 → NP_112152.1  proline-rich transmembrane protein 1 isoform 1

    See identical proteins and their annotated locations for NP_112152.1

    Status: VALIDATED

    Source sequence(s)
    CT009767
    Consensus CDS
    CCDS28653.1
    UniProtKB/Swiss-Prot
    O35449
    UniProtKB/TrEMBL
    A2CG20
    Related
    ENSMUSP00000015620.7, ENSMUST00000015620.7
    Conserved Domains (1) summary
    pfam04505
    Location:219 → 286
    CD225; Interferon-induced transmembrane protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34848396..34852108
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246470.4 → XP_011244772.1  proline-rich transmembrane protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011244772.1

    Conserved Domains (1) summary
    pfam04505
    Location:256 → 323
    CD225; Interferon-induced transmembrane protein

  2. XM_036160615.1 → XP_036016508.1  proline-rich transmembrane protein 1 isoform X3

    Conserved Domains (1) summary
    pfam04505
    Location:217 → 284
    CD225; Interferon-induced transmembrane protein

  3. XM_030249815.1 → XP_030105675.1  proline-rich transmembrane protein 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O35449.1 GenPept UniProtKB/Swiss-Prot:O35449

Gene LinkOut

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