ZZZ3 zinc finger ZZ-type containing 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZZZ3provided by HGNC
Official Full Name: zinc finger ZZ-type containing 3provided by HGNC
Primary source: HGNC:HGNC:24523
See related: Ensembl:ENSG00000036549 MIM:619892; AllianceGenome:HGNC:24523
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ATAC1
Summary: Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in histone H4 acetylation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thyroid (RPKM 9.6), ovary (RPKM 6.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p31.1

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (77562416..77683398, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (77401275..77522228, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (78028101..78149083, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identifies the ZZ domain of ZZZ3 as a histone H3 reader that is required for the ATAC complex-mediated maintenance of histone acetylation and gene activation.
Title: The ZZ-type zinc finger of ZZZ3 modulates the ATAC complex-mediated histone acetylation and gene activation.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH91759 (e-PCR)
- UniSTS:84741

G32941 (e-PCR)
- UniSTS:117519

D1S1611 (e-PCR), detects polymorphism
- UniSTS:24852

SHGC-75026 (e-PCR)
- UniSTS:41752

A009X17 (e-PCR)
- UniSTS:76321

SHGC-75041 (e-PCR)
- UniSTS:59686

RH119617 (e-PCR)
- UniSTS:133935

ZZZ3 (e-PCR)
- UniSTS:503880

A008Z12 (e-PCR)
- UniSTS:50784

SHGC-79372 (e-PCR)
- UniSTS:103268

SHGC-142743 (e-PCR)
- UniSTS:171627

G32603 (e-PCR)
- UniSTS:117186

A009K06 (e-PCR)
- UniSTS:19139

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone reader activity	IDA Inferred from Direct Assay more info	PubMed
enables lysine-acetylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell division	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of embryonic development	ISO Inferred from Sequence Orthology more info
involved_in regulation of embryonic development	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of tubulin deacetylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of tubulin deacetylation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of ATAC complex	IDA Inferred from Direct Assay more info	PubMed
part_of ATAC complex	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	NAS Non-traceable Author Statement more info	PubMed
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: ZZ-type zinc finger-containing protein 3

Names: ATAC component 1 homolog; zinc finger, ZZ domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001308237.2 → NP_001295166.1 ZZ-type zinc finger-containing protein 3 isoform 2

See identical proteins and their annotated locations for NP_001295166.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC093575, BC035079, BC035818, BX640658, CA448091

Consensus CDS

CCDS76172.1

UniProtKB/Swiss-Prot

Q8IYH5

Related

ENSP00000359834.1, ENST00000370798.5

Conserved Domains (2) summary

cd00167
Location:161 → 209

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02341
Location:327 → 378

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
NM_001376146.1 → NP_001363075.1 ZZ-type zinc finger-containing protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Consensus CDS

CCDS677.1

UniProtKB/Swiss-Prot

B7WPC6, Q6N004, Q6N070, Q8IYH5, Q8IYP0, Q8IYR1, Q8TEK4, Q9Y4U0

Conserved Domains (2) summary

cd02341
Location:821 → 872

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:655 → 703

Myb_DNA-binding; Myb-like DNA-binding domain
NM_001376147.1 → NP_001363076.1 ZZ-type zinc finger-containing protein 3 isoform 1

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Consensus CDS

CCDS677.1

UniProtKB/Swiss-Prot

B7WPC6, Q6N004, Q6N070, Q8IYH5, Q8IYP0, Q8IYR1, Q8TEK4, Q9Y4U0

Conserved Domains (2) summary

cd02341
Location:821 → 872

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:655 → 703

Myb_DNA-binding; Myb-like DNA-binding domain
NM_001376148.1 → NP_001363077.1 ZZ-type zinc finger-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Conserved Domains (2) summary

cd02341
Location:820 → 871

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:654 → 702

Myb_DNA-binding; Myb-like DNA-binding domain
NM_001376149.1 → NP_001363078.1 ZZ-type zinc finger-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Conserved Domains (2) summary

cd02341
Location:820 → 871

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:654 → 702

Myb_DNA-binding; Myb-like DNA-binding domain
NM_001376151.1 → NP_001363080.1 ZZ-type zinc finger-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Conserved Domains (2) summary

cd02341
Location:820 → 871

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:654 → 702

Myb_DNA-binding; Myb-like DNA-binding domain
NM_001376153.1 → NP_001363082.1 ZZ-type zinc finger-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Conserved Domains (2) summary

cd02341
Location:820 → 871

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:654 → 702

Myb_DNA-binding; Myb-like DNA-binding domain
NM_001376154.1 → NP_001363083.1 ZZ-type zinc finger-containing protein 3 isoform 3

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Conserved Domains (2) summary

cd02341
Location:820 → 871

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:654 → 702

Myb_DNA-binding; Myb-like DNA-binding domain
NM_001376155.1 → NP_001363084.1 ZZ-type zinc finger-containing protein 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Consensus CDS

CCDS76172.1

Conserved Domains (2) summary

cd00167
Location:161 → 209

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02341
Location:327 → 378

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
NM_001376156.1 → NP_001363085.1 ZZ-type zinc finger-containing protein 3 isoform 4

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

Conserved Domains (2) summary

cd00167
Location:160 → 208

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02341
Location:326 → 377

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
NM_015534.6 → NP_056349.1 ZZ-type zinc finger-containing protein 3 isoform 1

See identical proteins and their annotated locations for NP_056349.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC093575, BX640658, BX641001, CA448091

Consensus CDS

CCDS677.1

UniProtKB/Swiss-Prot

B7WPC6, Q6N004, Q6N070, Q8IYH5, Q8IYP0, Q8IYR1, Q8TEK4, Q9Y4U0

Related

ENSP00000359837.3, ENST00000370801.8

Conserved Domains (2) summary

cd02341
Location:821 → 872

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

pfam00249
Location:655 → 703

Myb_DNA-binding; Myb-like DNA-binding domain

RNA

NR_164775.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549
NR_164776.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549
NR_164777.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC093575, AC114487, AC118549

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

77562416..77683398 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047417341.1 → XP_047273297.1 ZZ-type zinc finger-containing protein 3 isoform X3
XM_005270729.5 → XP_005270786.1 ZZ-type zinc finger-containing protein 3 isoform X2

See identical proteins and their annotated locations for XP_005270786.1

UniProtKB/Swiss-Prot

Q8IYH5

Conserved Domains (2) summary

cd00167
Location:161 → 209

SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

cd02341
Location:327 → 378

ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
XM_047417342.1 → XP_047273298.1 ZZ-type zinc finger-containing protein 3 isoform X3

Related

ENST00000481346.5
XM_047417333.1 → XP_047273289.1 ZZ-type zinc finger-containing protein 3 isoform X2
XM_047417337.1 → XP_047273293.1 ZZ-type zinc finger-containing protein 3 isoform X3
XM_047417326.1 → XP_047273282.1 ZZ-type zinc finger-containing protein 3 isoform X2
XM_047417329.1 → XP_047273285.1 ZZ-type zinc finger-containing protein 3 isoform X2
XM_047417325.1 → XP_047273281.1 ZZ-type zinc finger-containing protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

77401275..77522228 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054335873.1 → XP_054191848.1 ZZ-type zinc finger-containing protein 3 isoform X3
XM_054335868.1 → XP_054191843.1 ZZ-type zinc finger-containing protein 3 isoform X2
XM_054335874.1 → XP_054191849.1 ZZ-type zinc finger-containing protein 3 isoform X3
XM_054335871.1 → XP_054191846.1 ZZ-type zinc finger-containing protein 3 isoform X2
XM_054335872.1 → XP_054191847.1 ZZ-type zinc finger-containing protein 3 isoform X3
XM_054335869.1 → XP_054191844.1 ZZ-type zinc finger-containing protein 3 isoform X2
XM_054335870.1 → XP_054191845.1 ZZ-type zinc finger-containing protein 3 isoform X2
XM_054335867.1 → XP_054191842.1 ZZ-type zinc finger-containing protein 3 isoform X1